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Official Full Name WW domain containing E3 ubiquitin protein ligase 2
Background This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms WWP2; WW domain containing E3 ubiquitin protein ligase 2; NEDD4-like E3 ubiquitin-protein ligase WWP2; AIP2; Atrophin 1 interacting protein 2; NEDD4 like E3 ubiquitin protein ligase; WW domain-containing protein 2; Wwp 2; atrophin-1 interacting protein 2; atrophin-1-interacting protein 2; Nedd-4-like ubiquitin-protein ligase; WWp2-like
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human WWP2-001HCL Recombinant Human WWP2 cell lysate Insect Cell N/A
    Human WWP2-1806H Recombinant Human WWP2 protein, His & T7-tagged E.coli His/T7
    Human WWP2-240H Recombinant Human WWP2, GST-tagged Sf9 Insect Cell GST
    Human WWP2-3747H Recombinant Human WWP2, GST-tagged E.coli GST
    Human WWP2-376H Recombinant Human WWP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human WWP2-652H Recombinant Human WWP2 Protein, GST-tagged, Active Insect Cell GST
    Human WWP2-7349H Recombinant Human WWP2, His & GST tagged Insect Cell His/GST
    Rhesus Macaque WWP2-5225R Recombinant Rhesus monkey WWP2 Protein, His-tagged Mammalian Cell His
    Chicken WWP2-3325C Recombinant Chicken WWP2 Mammalian Cell His
    Zebrafish WWP2-5774Z Recombinant Zebrafish WWP2 Mammalian Cell His

    WWP2 involved in several pathways and played different roles in them. We selected most pathways WWP2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with WWP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis DET1; UBE2J1; UBE2L3B; UBE2L3A; AIRE; CDC20; UBE2Z; UBE2H; UBA6; CDC26

    WWP2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by WWP2 itself. We selected most functions WWP2 had, and list some proteins which have the same functions with WWP2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription factor binding KDM1A; DHX9; GSC; GATA4; Ar; GATA5; GATA2; SFPI1; WWP2; GSK3B
    ligase activity FANCL; ZSWIM2; TRIM69; UBE2NB; UHRF2; RNF169; PIAS3; UBE2L3B; TRIM17; TRIM27
    protein binding CSK; UBE2D2; ZNF624; RAB26; DLL4; AAAS; SAMD4A; CDC25B; SMYD2; ITGB3
    transcription factor binding TRERF1; TAF1; MED1; SORBS3; NAB2; SOX8; HEYL; TRIB2; NKX3-1; ESR1
    transcriptional activator activity, RNA polymerase II transcription factor binding NR1H4; FOXH1; PITX1; CLOCK; NKX2-5; NOTCH1; SOX10; NFE2L1; GBX2; JUN
    ubiquitin protein ligase activity SIAH1; UBE2G1B; CCNC; MED20; MYLIP; TRAF6; MARCH1; RNF14; RNF144A; MARCH8
    ubiquitin-protein transferase activity RNF146; MIB2; ZFP91; SHPRH; FBXO22; UBE2G1; RNF187; HECTD3; RNF144AB; UBE2D2

    WWP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WWP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WWP2.


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