wwp2
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  • Official Full Name
  • WW domain containing E3 ubiquitin protein ligase 2
  • Background
  • This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Synonyms
  • WWP2; WW domain containing E3 ubiquitin protein ligase 2; NEDD4-like E3 ubiquitin-protein ligase WWP2; AIP2; Atrophin 1 interacting protein 2; NEDD4 like E3 ubiquitin protein ligase; WW domain-containing protein 2; Wwp 2; atrophin-1 interacting protein 2; atrophin-1-interacting protein 2; Nedd-4-like ubiquitin-protein ligase; WWp2-like
Cat.#:WWP2-376HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human WWP2 Protein, MYC/DDK-tagged
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Cat.#:WWP2-1806HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WWP2 protein, His & T7-tagged
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Cat.#:WWP2-240HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human WWP2, GST-tagged
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Cat.#:WWP2-3747HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human WWP2, GST-tagged
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Cat.#:WWP2-652HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human WWP2 Protein, GST-tagged, Active
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Cat.#:WWP2-7349HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human WWP2, His & GST tagged
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Cat.#:WWP2-5225RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey WWP2 Protein, His-tagged
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Cat.#:WWP2-3325CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken WWP2
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Cat.#:WWP2-5774ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish WWP2
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Cat.#:WWP2-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human WWP2 cell lysate
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Involved Pathway

WWP2 involved in several pathways and played different roles in them. We selected most pathways WWP2 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with WWP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
UBE2L3; UBE2L3B; FBXO4; UBE2D2A; UBE2E2; SOCS3; UBE2B; PIAS4; CUL5; UBE2NB

Protein Function

WWP2 has several biochemical functions, for example, RNA polymerase II transcription factor binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WWP2 itself. We selected most functions WWP2 had, and list some proteins which have the same functions with WWP2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription factor binding
Related Protein ANKRD1; CREBBP; ZFPM2; GATA2B; WWP2; TRPS1; GATA4; TOX2; NFATC1; TEAD3
Function ligase activity
Related Protein UBE2G1A; RCHY1; KCMF1; NEDD4; TRIM31; TRIM11; MARCH10; MUL1; RAG1; MARCH4
Function protein binding
Related Protein GBP2; RAB1; N4BP2L2; MAPRE3; TRPM8; AIMP2; IGHM; BRMS1; SMAP2; WDR34
Function transcription factor binding
Related Protein UBE2I; MDFIC; HDAC11; CTNNB1; PARP1; PPP1R13B; ATOH8; PPARG; POU5F1; SMAD2
Function transcriptional activator activity, RNA polymerase II transcription factor binding
Related Protein CREB1; NKX2-5; NR1H4; SOX10; KLF4; NKX2; MED12; KLF14; LMO2; CLOCK
Function ubiquitin protein ligase activity
Related Protein XIAP; UBE2NA; UBE2G2; TOPORS; SIAH1; WWP2; MED31; PDZD4; UBE2KB; MARCH1
Function ubiquitin-protein transferase activity
Related Protein FBXO3; RNF144B; ARIH1; TRIM17; MUL1B; AMFR; SMURF2; BIRC5A; BIRC3; HACE1

Interacting Protein

WWP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WWP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WWP2.
WIPF1; HNRNPUL1; TRAF4; PDLIM7; SMAD3