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WWP2

  • Official Full Name

    WW domain containing E3 ubiquitin protein ligase 2

  • Overview

    This gene encodes a member of the NEDD4-like protein family. The family of proteins is known to possess ubiquitin-protein ligase activity. The encoded protein contains 4 tandem WW domains. The WW domain is a protein motif consisting of 35 to 40 amino acids and is characterized by 4 conserved aromatic residues. The WW domain may mediate specific protein-protein interactions. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Synonyms

    WWP2; WW domain containing E3 ubiquitin protein ligase 2; NEDD4-like E3 ubiquitin-protein ligase WWP2; AIP2; Atrophin 1 interacting protein 2; NEDD4 like E3 ubiquitin protein ligase; WW domain-containing protein 2; Wwp 2; atrophin-1 interacting protein 2; atrophin-1-interacting protein 2; Nedd-4-like ubiquitin-protein ligase; WWp2-like;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WWP2-652H Active Recombinant Human WWP2 Protein, GST-tagged Insect Cell GST
Human WWP2-7349H Recombinant Human WWP2 protein, His&GST-tagged Insect Cells His/GST Met1-Glu870
Human WWP2-3747H Recombinant Human WWP2, GST-tagged E.coli GST N-term-355aa
Human WWP2-240H Recombinant Human WWP2, GST-tagged Sf9 Insect Cell GST
Human WWP2-001HCL Recombinant Human WWP2 cell lysate Insect Cell N/A
Human WWP2-376H Recombinant Human WWP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human WWP2-3754H Recombinant Human WWP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human WWP2-1806H Recombinant Human WWP2 protein, His & T7-tagged E.coli His/T7 His601~Glu870 (Accession # O00308)
Human WWP2-5585H Recombinant Human WWP2 Protein (His601-Glu870), N-His tagged E.coli N-His His601-Glu870
Human WWP2-2842H Recombinant Human WWP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human WWP2-3842H Recombinant Human WWP2 protein, His-tagged E.coli His 1-355 aa
Human WWP2-0442H Recombinant Human WWP2 Protein (A2-E870), Tag Free E.coli No tag A2-E870
Human WWP2-0443H Recombinant Human WWP2 Protein (A2-E870), His tagged E.coli His A2-E870
Mouse Wwp2-7015M Recombinant Mouse Wwp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque WWP2-5225R Recombinant Rhesus monkey WWP2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque WWP2-5038R Recombinant Rhesus Macaque WWP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque WWP2-5038R-B Recombinant Rhesus Macaque WWP2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish WWP2-5774Z Recombinant Zebrafish WWP2 Mammalian Cell His
Chicken WWP2-3325C Recombinant Chicken WWP2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

WWP2 involved in several pathways and played different roles in them. We selected most pathways WWP2 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with WWP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisANAPC1;UBE2KB;ANAPC4;UBE2B;RFWD2;TRIM32;UBE2D1A;UBE2D1B;UBE4A

WWP2 has several biochemical functions, for example, RNA polymerase II transcription factor binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WWP2 itself. We selected most functions WWP2 had, and list some proteins which have the same functions with WWP2. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription factor bindingSPOP;KLF4;MIXL1;ZGLP1;CREBBP;TOX2;TEAD3;T;GATA4
ligase activitySMURF2;NEDD4L;MYLIP;MARCH8;CMTM2A;TRIML2;EGR2;MARCH2;MARCH1
protein bindingDHDDS;POLR3GL;RARRES3;FZD2;ANKRD17;POLR3F;CHMP5;RSU1;DACT1
transcription factor bindingSIRT2;KDM1A;FOXA2;MECP2;HAND1;ZFPM2;TFAP2A;GTF2B;PIM1
transcriptional activator activity, RNA polymerase II transcription factor bindingFOXH1;NKX2;WWP2;CLOCK;MED12;GBX2;SOX10;JUN;PPARA
ubiquitin protein ligase activityUBE2G2;ARIH2;PDZRN3B;TRAF6;RNF144AB;MED24;RNF25;UBE2J2;HECTD1
ubiquitin-protein transferase activityITCHA;UBE2H;RNF25;FBXO3;TRAF5;RNF182;RFWD3;UHRF1;RNF181

WWP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WWP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WWP2.

WIPF1; HNRNPUL1; TRAF4; PDLIM7; SMAD3

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