| Description : |
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
98.7 kDa |
| AA Sequence : |
MASASSSRAGVALPFEKSQLTLKVV SAKPKVHNRQPRINSYVEVAVDGLP SETKKTGKRIGSSELLWNEIIILNV TAQSHLDLKVWSCHTLRNELLGTAS VNLSNVLKNNGGKMENMQLTLNLQT ENKGSVVSGGELTIFLDGPTVDLGN VPNGSALTDGSQLPSRDSSGTAVAP ENRHQPPSTNCFGGRSRTHRHSGAS ARTTPATGEQSPGARSRHRQPVKNS GHSGLANGTVNDEPTTATDPEEPSV VGVTSPPAAPLSVTPNPNTTSLPAP ATPAEGEEPSTSGTQQLPAAAQAPD ALPAGWEQRELPNGRVYYVDHNTKT TTWERPLPPGWEKRTDPRGRFYYVD HNTRTTTWQRPTAEYVRNYEQWQSQ RNQLQGAMQHFSQRFLYQSSSASTD HDPLGPLPPGWEKRQDNGRVYYVNH NTRTTQWEDPRTQGMIQEPALPPGW EMKYTSEGVRYFVDHNTRTTTFKDP RPGFESGTKQGSPGAYDRSFRWKYH QFRFLCHSNALPSHVKISVSRQTLF EDSFQQIMNMKPYDLRRRLYIIMRG EEGLDYGGIAREWFFLLSHEVLNPM YCLFEYAGKNNYCLQINPASSINPD HLTYFRFIGRFIAMALYHGKFIDTG FTLPFYKRMLNKRPTLKDLESIDPE FYNSIVWIKENNLEECGLELYFIQD MEILGKVTTHELKEGGESIRVTEEN KEEYIMLLTDWRFTRGVEEQTKAFL DGFNEVAPLEWLRYFDEKELELMLC GMQEIDMSDWQKSTIYRHYTKNSKQ IQWFWQVVKEMDNEKRIRLLQFVTG TCRLPVGGFAELIGSNGPQKFCIDK VGKETWLPRSHTCFNRLDLPPYKSY EQLREKLLYAIEETEGFGQETRTRP LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
