WNT3

  • Official Full Name

    wingless-related MMTV integration site 3

  • Overview

    Defects in WNT3 are the cause of autosomal recessive tetra-amelia (ARTTRA). Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects.

  • Synonyms

    WNT3;wingless-related MMTV integration site 3;Int-4;Wnt-3;proto-oncogene Wnt-3;proto-oncogene Int-4;proto-oncogene protein Wnt-3

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Zebrafish
  • Cattle
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • CHO
  • Yeast
  • In Vitro Cell Free System
  • Non
  • His
  • GST
  • Flag
  • SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
WNT3-5160M Active Recombinant Mouse WNT3 Mouse Non
WNT3-3738H Recombinant Human WNT3, His-tagged E.coli Human His 1-355aa
WNT3-3076H Recombinant Human WNT3 protein, His-tagged E.coli Human His 130-306 aa
WNT3-3658C Recombinant Chicken WNT3 Mammalian Cells Chicken His
WNT3-5161H Recombinant Human WNT3, GST-tagged Wheat Germ Human GST
WNT3-6430Z Recombinant Zebrafish WNT3 Mammalian Cells Zebrafish His
WNT3-296HCL Recombinant Human WNT3 293 Cell Lysate HEK293 Human Non
WNT3-3739H Recombinant Human WNT3 Protein, DDK-tagged CHO Human Flag
WNT3-5162M Recombinant Mouse WNT3 Protein, His-tagged E.coli Mouse His 22-355aa
WNT3-5163M Recombinant Mouse WNT3 Protein, His-SUMO-tagged E.coli Mouse His&SUMO 22-355aa
WNT3-5164M Recombinant Mouse WNT3 Protein, His-tagged Yeast Mouse His 22–355aa
WNT3-549HF Recombinant Full Length Human WNT3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 385 amino acids
WNT3-584C Recombinant Cattle WNT3 Protein, His-tagged E.coli Cattle His Val19-Lys355

    Involved Pathway

    WNT3 involved in several pathways and played different roles in them. We selected most pathways WNT3 participated on our site, such as Wnt signaling pathway,Hedgehog signaling pathway,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WNT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt signaling pathway PPP3R1,PRICKLE2B,BTRC,TCF7L1A,DAAM1B,CAMK2B1,WNT5A,WNT5B,RAC3B,DKK4
    Proteoglycans in cancer FZD1,PRKACB,TNF,CAMK2D,PPP1R12A,PPP1R12B,CD44,PAK1,MAP2K2,MAPK11
    Pathways in cancer FGFR2,PIK3CG,FGF16,Ar,PPARG,FGF14,PIK3R2,AGTR1B,SKP2,CDC42
    Hippo signaling pathway PARD6A,PPP1CC,ACTG1,CTNNA2,WNT1,PPP2R1B,ACTB,DVL3,GLI2,GDF5
    Hedgehog signaling pathway GAS1A,WNT9B,WNT4A,WNT3A,CSNK1G3,WNT7A,CSNK1G2A,PTCH2,GSK3B,WNT11B
    Melanogenesis a,CREB3L3L,KITA,TCF7,WNT11R,WNT7A,CAMK2B,TYRP1,FZD9B,CAMK2D
    Signaling pathways regulating pluripotency of stem cells BMI1,PIK3R5,MAPK1,STAT3,IGF1R,WNT7A,INHBC,MAPK3,SMAD1,WNT4
    MicroRNAs in cancer SHC4,CCND2,PRKCB,ST14,ERBB3,SOX4,MDM2,FSCN1,KRAS,PDGFRB
    Basal cell carcinoma GSK3B,BMP2,FZD5,Fzd4,SETD6,HHIP,PTCH2,GLI1,WNT5B,WNT4

    Protein Function

    WNT3 has several biochemical functions, for example, frizzled binding,protein binding,protein domain specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WNT3 itself. We selected most functions WNT3 had, and list some proteins which have the same functions with WNT3. You can find most of the proteins on our site.

    Function Related Protein
    protein domain specific binding YWHAE,VRK2,SCAF1,PPARA,HAND2,ICA1L,GUSB,IST1,HIST1H4F,ZFP521
    receptor agonist activity WNT8A,GAS6,WNT5A,WNT7A,SFRP2,WNT2,VEGFA,WNT1,NODAL,GREM1
    protein binding POT1,PCBD1,FBXO34,GNA13,MAPRE3,IFT27,BCL2L15,TRIM22,SQSTM1,ATXN7L3
    frizzled binding DVL3,WNT7A,ROR2,WNT10B,WNT11,MYOC,WNT8A,SDCBP,DVL1B,WNT5A

    Interacting Protein

    WNT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WNT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of WNT3.

    FZD7

    WNT3 Related Signal Pathway

    Resources

    Gene Families

    References

    • Lighthouse, JK; Zhang, L; et al. MESD Is Essential for Apical Localization of Megalin/LRP2 in the Visceral Endoderm. DEVELOPMENTAL DYNAMICS 240:577-588(2011).
    • Ettenberg, SA; Charlat, O; et al. Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:15473-15478(2010).

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