xrcc3
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  • Official Full Name
  • X-ray repair complementing defective repair in Chinese hamster cells 3
  • Background
  • This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
  • Synonyms
  • XRCC3; X-ray repair complementing defective repair in Chinese hamster cells 3; DNA repair protein XRCC3; RAD51 like; X-ray repair cross-complementing protein 3; CMM6
Cat.#:XRCC3-30133THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XRCC3, T7 -tagged
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Cat.#:XRCC3-3057HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XRCC3, T7-tagged
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Cat.#:XRCC3-627HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XRCC3 Protein, His-tagged
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Cat.#:XRCC3-628HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XRCC3 Protein, His-tagged
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Cat.#:XRCC3-629HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XRCC3 Protein, His-tagged
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Cat.#:XRCC3-7094HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XRCC3, His-tagged
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Cat.#:XRCC3-18637MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse XRCC3 Protein
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Cat.#:XRCC3-1628CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken XRCC3
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Cat.#:XRCC3-2205ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish XRCC3
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Cat.#:XRCC3-256HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human XRCC3 293 Cell Lysate
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Involved Pathway

XRCC3 involved in several pathways and played different roles in them. We selected most pathways XRCC3 participated on our site, such as Homologous recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Homologous recombination
MUS81; BRCA2; RAD54B; RAD51; BLM; RAD54L; RAD51L3; CDK5R2; RAD51D; SYCP3

Protein Function

XRCC3 has several biochemical functions, for example, ATP binding, DNA-dependent ATPase activity, contributes_to crossover junction endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC3 itself. We selected most functions XRCC3 had, and list some proteins which have the same functions with XRCC3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NOD1; MAP2K4A; ABCC12; UBE2L3B; NLRC5; ABCC1; HK1; RUNX2A; ATP2C1; SMC4
Function DNA-dependent ATPase activity
Related Protein RAD51L3; CHD8; DMC1; SMARCA4; SMARCA2; CHD6; MSH3; MSH6; MSH2; XRCC2
Function contributes_to crossover junction endodeoxyribonuclease activity
Related Protein RAD51C; XRCC3; SLX4
Function double-stranded DNA binding
Related Protein HNRPDL; DDX11; RAD51; XRCC3; RAD51C; SP1; NEIL3; RAD51B; SP8B; PRKDC
Function contributes_to four-way junction DNA binding
Related Protein RAD51C; RAD51B; XRCC2; XRCC3; MSH6; RAD51D; RAD51L3; RAD51L1; MSH2
Function protein binding
Related Protein TBATA; TPD52; KLRC4-KLRK1; LILRB3; ZNF180; DHX16; DCPS; IL18; KCTD1; THAP7
Function recombinase activity
Related Protein RAD51B; XRCC3; DMC1; RAD51L3; RAD51D; XRCC2; RAD51; RBPJ; RAD51C; RAD51L1
Function single-stranded DNA binding
Related Protein NME2; MLH3; ALYREF; CNBP; RAD51AP1; LONP1; DDX11; TREX1; NCL; FUBP1

Interacting Protein

XRCC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC3.
RAD51C; RAD51; PALB2; BRCA2; SWSAP1; ZSWIM7; SNAI1

XRCC3 Related Articles

Kajita, M; Okazawa, T; et al. Efficient affinity maturation of antibodies in an engineered chicken B cell line DT40-SW by increasing point mutation. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 110:351-358(2010).
Kajita, M; Magari, M; et al. Conditional transformation of immunoglobulin mutation pattern from gene conversion into point mutation by controlling XRCC3 expression in the DT40 B cell line. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 109:407-410(2010).