Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

XRCC3

Official Full Name

X-ray repair complementing defective repair in Chinese hamster cells 3
Overview

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
Synonyms

XRCC3; X-ray repair complementing defective repair in Chinese hamster cells 3; DNA repair protein XRCC3; RAD51 like; X-ray repair cross-complementing protein 3; CMM6;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
SUMO
N/A
N
T7

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	XRCC3-7094H	Recombinant Human XRCC3, His-tagged	E.coli	His	1-346aa	Inquiry
Human	XRCC3-628H	Recombinant Human XRCC3 Protein, His-tagged	E.coli	His		Inquiry
Human	XRCC3-30133TH	Recombinant Human XRCC3, T7 -tagged	E.coli	T7		Inquiry
Human	XRCC3-3057H	Recombinant Human XRCC3, T7-tagged	E.coli	T7		Inquiry
Human	XRCC3-627H	Recombinant Human XRCC3 Protein, His-tagged	E.coli	His		Inquiry
Human	XRCC3-629H	Recombinant Human XRCC3 Protein, His-tagged	E.coli	His		Inquiry
Human	XRCC3-256HCL	Recombinant Human XRCC3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	XRCC3-3772H	Recombinant Human XRCC3 protein, His-SUMO-tagged	E.coli	His-SUMO	1-316aa	Inquiry
Human	XRCC3-598H	Recombinant Human XRCC3 Protein, His-tagged	E.coli	N-His	Met1-Phe249	Inquiry
Mouse	XRCC3-18637M	Recombinant Mouse XRCC3 Protein	Mammalian Cell	His		Inquiry
Mouse	XRCC3-10241M	Recombinant Mouse XRCC3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	XRCC3-10241M-B	Recombinant Mouse XRCC3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Xrcc3-599M	Recombinant Mouse Xrcc3 Protein, His-tagged	E.coli	N-His	Met1-His224	Inquiry
Zebrafish	XRCC3-2205Z	Recombinant Zebrafish XRCC3	Mammalian Cell	His		Inquiry
Chicken	XRCC3-1628C	Recombinant Chicken XRCC3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
XRCC3 Related Articles

XRCC3 involved in several pathways and played different roles in them. We selected most pathways XRCC3 participated on our site, such as Homologous recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Homologous recombination	EME1;RAD54L;SSBP1;MRE11A;BRCA2;POLD2;CDK5R2;XRCC3;SHFM1

XRCC3 has several biochemical functions, for example, ATP binding, DNA-dependent ATPase activity, contributes_to crossover junction endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC3 itself. We selected most functions XRCC3 had, and list some proteins which have the same functions with XRCC3. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	TOR1B;TNK1;DGKG;GSK3AB;ALK;NEK7;STK38A;FGFR2;MAPK8
DNA-dependent ATPase activity	IGHMBP2;ERCC2;ERCC6;DDX11;XRCC3;RAD51B;MSH5;CHD8;SMARCA2
contributes_to crossover junction endodeoxyribonuclease activity	SLX4;RAD51C;XRCC3
double-stranded DNA binding	FBXO18;MRE11A;CGGBP1;NTHL1;TRP53;TARDBP;SETMAR;EGFR;KLF6
contributes_to four-way junction DNA binding	RAD51C;RAD51L1;RAD51L3;RAD51B;RAD51D;XRCC2;MSH2;XRCC3;MSH6
protein binding	NEGR1;HEY2;HP;CENPL;ZNF496;NTHL1;CTBP1;ZP3;HMGN2
recombinase activity	RAD51D;RAD51L1;RAD51B;DMC1;XRCC3;RBPJ;RAD51L3;RAD51;RAD51C
single-stranded DNA binding	HNRNPK;SSBP1;ANXA1;SSBP2;HMGB1;OBFC2B;SSBP3A;RAD51AP1;NME2

XRCC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC3.

RAD51C; RAD51; PALB2; BRCA2; SWSAP1; ZSWIM7; SNAI1

Kajita, M; Okazawa, T; et al. Efficient affinity maturation of antibodies in an engineered chicken B cell line DT40-SW by increasing point mutation. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 110:351-358(2010).

Kajita, M; Magari, M; et al. Conditional transformation of immunoglobulin mutation pattern from gene conversion into point mutation by controlling XRCC3 expression in the DT40 B cell line. JOURNAL OF BIOSCIENCE AND BIOENGINEERING 109:407-410(2010).