xrcc4
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  • Official Full Name
  • X-ray repair complementing defective repair in Chinese hamster cells 4
  • Background
  • The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants.
  • Synonyms
  • XRCC4; X-ray repair complementing defective repair in Chinese hamster cells 4; DNA repair protein XRCC4; X ray repair; complementing defective; repair in Chinese hamster; X-ray repair cross-complementing protein 4; X-ray repair, complementing defective, r
Cat.#:XRCC4-1003HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human XRCC4 protein, MYC/DDK-tagged
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Cat.#:XRCC4-1004HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human XRCC4 protein, MYC/DDK-tagged
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Cat.#:XRCC4-30134THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XRCC4, His-tagged
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Cat.#:XRCC4-3757HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human XRCC4, GST-tagged
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Cat.#:XRCC4-18638MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse XRCC4 Protein
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Cat.#:XRCC4-1090CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus XRCC4 Protein, His-tagged
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Cat.#:XRCC4-11047ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish XRCC4
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Cat.#:XRCC4-255HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human XRCC4 293 Cell Lysate
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Involved Pathway

XRCC4 involved in several pathways and played different roles in them. We selected most pathways XRCC4 participated on our site, such as Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with XRCC4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Non-homologous end-joining
MRE11A; LIG4; PRKDC; XRCC4; POLL; XRCC6; DNTT; XRCC5; FEN1; DCLRE1C

Protein Function

XRCC4 has several biochemical functions, for example, NOT DNA binding, NOT ligase activity, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by XRCC4 itself. We selected most functions XRCC4 had, and list some proteins which have the same functions with XRCC4. You can find most of the proteins on our site.
Function
Related Protein
Function NOT DNA binding
Related Protein HIPK2; SKIL; XRCC4; NFIB; MBD5; TINF2
Function NOT ligase activity
Related Protein XRCC4
Function protein C-terminus binding
Related Protein ITPR1; CLIC6; MSH2; TERF2; ITGB3BP; XRCC4; KSR1; COIL; SIAH1A; PEX16
Function protein binding
Related Protein C1orf187; KCNH7; FCNA; CCT2; ZBP1; MLANA; DOT1L; PDP1; CDH5; NUB1

Interacting Protein

XRCC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XRCC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of XRCC4.
PNKP; NHEJ1; APLF

XRCC4 Related Articles

Palomino, GM; Bassi, CL; et al. Patients with Systemic Sclerosis Present Increased DNA Damage Differentially Associated with DNA Repair Gene Polymorphisms. JOURNAL OF RHEUMATOLOGY 41:458-465(2014).
Vignard, J; Mirey, G; et al. Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up. RADIOTHERAPY AND ONCOLOGY 108:362-369(2013).