• Official Full Name
  • zinc finger and BTB domain containing 33
  • Background
  • This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
  • Synonyms
  • ZBTB33; zinc finger and BTB domain containing 33; transcriptional regulator Kaiso; kaiso; WUGSC:H_DJ525N14.1; ZNF kaiso; ZNF348; Kaiso protein; Kaiso transcription factor; KAISO_HUMAN; ZBTB 33; Zinc finger and BTB domain-containing protein 33; Zinc finger transcription factor Kaiso; ZNF 348; OTTHUMP00000023933; OTTHUMP00000245265; ZNF-kaiso
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ZBTB33 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ZBTB33
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ZBTB33
Source (Host):Species:Human
Product nameRecombinant Human ZBTB33 cell lysate

Involved Pathway

ZBTB33 involved in several pathways and played different roles in them. We selected most pathways ZBTB33 participated on our site, such as Wnt Signaling Pathway and Pluripotency, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZBTB33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt Signaling Pathway and Pluripotency

Protein Function

ZBTB33 has several biochemical functions, for example, metal ion binding, methyl-CpG binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZBTB33 itself. We selected most functions ZBTB33 had, and list some proteins which have the same functions with ZBTB33. You can find most of the proteins on our site.
Related Protein
Function metal ion binding
Related Protein ZXDB; FGD4A; ZNF16; JUB; DMRTA2; EXT1; LMAN1; ZFP879; SPATA21; OVOL1
Function methyl-CpG binding
Related Protein ZBTB33; MBD3A; UHRF1; MBD3B; MBD3L1; MBD1B; DNMT1; MECP2; ZNF295; ZBTB4
Function protein binding
Related Protein AKAP8L; CRB3; YWHAG; NKX2-1; TPSAB1; TOMM7; PIGK; RUNX3; DSC2; GCH1
Function sequence-specific DNA binding

Interacting Protein

ZBTB33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZBTB33 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZBTB33.
CTNND1; WDR48; q81sn0_bacan; AIM2; SF3B1; FOXM1; TRIML2; RNF169; TRMT10A; CCDC101; CLPTM1L; DPH7; KLF16; CCDC61