ZIC1 Protein, Zic family member 1


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Official Full Name Zic family member 1
Background This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]
Synonyms ZIC1; Zic family member 1; ZIC; ZNF201; zinc finger protein ZIC 1; zinc finger protein 201; Zinc finger protein of the cerebellum 1; Zic family member 1 (odd-paired homolog, Drosophila);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ZIC1-31656TH Recombinant Human ZIC1 Wheat Germ N/A
    Human ZIC1-440H Recombinant Human ZIC1 Protein, His-tagged E.coli His
    Mouse ZIC1-19176M Recombinant Mouse ZIC1 Protein Mammalian Cell His
    Chicken ZIC1-5827C Recombinant Chicken ZIC1 Mammalian Cell His
    Zebrafish ZIC1-8574Z Recombinant Zebrafish ZIC1 Mammalian Cell His

    ZIC1 involved in several pathways and played different roles in them. We selected most pathways ZIC1 participated on our site, such as Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZIC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neural Crest Differentiation OLIG1; MBP; ASCL1; HOXA1; CDH6; OLIG2; CTBP2; TFAP2A; CDH7; TBX6

    ZIC1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, metal ion binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZIC1 itself. We selected most functions ZIC1 had, and list some proteins which have the same functions with ZIC1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding E2F8; CC2D1B; HELT; MSX2; ZNF680; FEZF1; ZNF395; BCL11B; ELF4; IFI16
    metal ion binding NUDT1; KLF15; CNOT6L; COL5A1; PPTC7A; ZFP653; CYP19A1B; BMPR2; KDM1B; RAF1
    transcription factor activity, sequence-specific DNA binding CNOT8; NFIC; NFE2L2B; TADA2A; NPAS2; ZNF789; CLOCKA; MSC; FOXN4; FLI1A
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding TFAM; FOS; TRP53; NEUROD6; FOXK2; POU4F2; GRHL1; CREB3L1; SIX1; MYOCD

    ZIC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZIC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZIC1.

    Aruga, J; Nozaki, Y; et al. Expression of ZIC family genes in meningiomas and other brain tumors. BMC CANCER 10:-(2010).
    Degreef, I; De Smet, L; et al. Immunohistochemical evidence for Zic1 coexpression with -catenin in the myofibroblast of Dupuytren disease. SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY 43:36-40(2009).

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