znrf1
Share
  • Official Full Name
  • zinc and ring finger 1, E3 ubiquitin protein ligase
  • Background
  • In a study identifying genes in rat that are upregulated in response to nerve damage, a gene which is highly expressed in ganglia and in the central nervous system was found. The protein encoded by the rat gene contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly similar in sequence to that encoded by the rat gene.
  • Synonyms
  • ZNRF1; zinc and ring finger 1, E3 ubiquitin protein ligase; zinc and ring finger 1; E3 ubiquitin-protein ligase ZNRF1; DKFZp434E229; FLJ14846; nin283; nerve injury gene 283; zinc/RING finger protein 1; zinc and ring finger protein 1; nerve injury-induced
Cat.#:ZNRF1-134HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ZNRF1, GST-tagged
+Inquiry
Cat.#:ZNRF1-3880HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ZNRF1, His-tagged
+Inquiry
Cat.#:ZNRF1-443HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ZNRF1 Protein, His-tagged
+Inquiry
Cat.#:ZNRF1-19219MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ZNRF1 Protein
+Inquiry
Cat.#:ZNRF1-5371RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ZNRF1 Protein, His-tagged
+Inquiry
Cat.#:ZNRF1-11118ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ZNRF1
+Inquiry
Cat.#:ZNRF1-2097HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ZNRF1 cell lysate
+Inquiry

Protein Function

ZNRF1 has several biochemical functions, for example, ligase activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ZNRF1 itself. We selected most functions ZNRF1 had, and list some proteins which have the same functions with ZNRF1. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein RNF170; HECW2; RTCD1; TRIM71; TRIM4; MYLIPA; BRCA1; UFL1; CNOT4; HLTF
Function protein binding
Related Protein IFI35; KLHDC3; PEX6; FKBP4; CALM3; YTHDC1; DNAJB6; SGK1; SNRPB2; NSG1
Function ubiquitin protein ligase activity
Related Protein SIAH1; ARIH2; UBE2J2; CBLC; RNF144B; BFAR; WWP2; RNF149; TRIM37; PDZRN4
Function ubiquitin-protein transferase activity
Related Protein RNF182; RNF152; RNF43; TRIM33; UBR1; HECW1B; MDM2; RNF144AB; RBBP6; UBE2T
Function zinc ion binding
Related Protein MARCH5; DNPEP; SOD1; LTN1; CIZ1; QPCT; ZDHHC15; TRIM4; DTNBA; SYVN1

Interacting Protein

ZNRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZNRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZNRF1.
UBE2D1; UBE2D2; UBE2E1; UBE2D3; UBE2N; UBE2D4

ZNRF1 Related Articles

Stinton, LM; Myers, RP; et al. Clinical associations and potential novel antigenic targets of autoantibodies directed against rods and rings in chronic hepatitis C infection. BMC GASTROENTEROLOGY 13:-(2013).
Xiong, R; Nie, L; et al. Characterization of a PIAS4 Homologue from Zebrafish: Insights into Its Conserved Negative Regulatory Mechanism in the TRIF, MAVS, and IFN Signaling Pathways during Vertebrate Evolution. JOURNAL OF IMMUNOLOGY 188:2653-2668(2012).