ZP3 Protein, zona pellucida glycoprotein 3 (sperm receptor)


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Official Full Name zona pellucida glycoprotein 3 (sperm receptor)
Background The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]
Synonyms ZP3; zona pellucida glycoprotein 3 (sperm receptor); ZPC; ZP3A; ZP3B; Zp-3; zona pellucida sperm-binding protein 3; ZP3A/ZP3B; sperm receptor; zona pellucida protein C; zona pellucida glycoprotein 3B; zona pellucida glycoprotein ZP3; zona pellucida glycoprotein 3A (sperm receptor);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ZP3-1275H Recombinant Human ZP3 Protein (23-346 aa), GST-tagged E.coli GST
    Human ZP3-1055H Recombinant Human ZP3 Protein, His-tagged Mammalian cells His
    Human ZP3-2099HCL Recombinant Human ZP3 cell lysate N/A
    Mouse ZP3-19225M Recombinant Mouse ZP3 Protein Mammalian Cell His
    Rat ZP3-6716R Recombinant Rat ZP3 Protein Mammalian Cell His
    Chicken ZP3-5959C Recombinant Chicken ZP3 Mammalian Cell His
    Zebrafish ZP3-8918Z Recombinant Zebrafish ZP3 Mammalian Cell His

    ZP3 involved in several pathways and played different roles in them. We selected most pathways ZP3 participated on our site, such as Fertilization, Interaction With The Zona Pellucida, Ovarian Infertility Genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Interaction With The Zona Pellucida ADAM2; ADAM20; ADAM21; OVGP1; ZP3; ADAM30; ZP2
    Ovarian Infertility Genes ZP2; NR5A1; SYNE2; MSH5; DAZL; NRIP1; DMC1; INHA; ZP3; GJA4

    ZP3 has several biochemical functions, for example, acrosin binding, carbohydrate binding, manganese ion transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ZP3 itself. We selected most functions ZP3 had, and list some proteins which have the same functions with ZP3. You can find most of the proteins on our site.

    Function Related Protein
    acrosin binding ZP2; ZP3; SERPINA5
    carbohydrate binding LGALS7B; CNTN1; SIGLEC8; LGALS2A; CD209; CHODL; MAN2C1; ZP3; GALNT3; CD34
    manganese ion transmembrane transporter activity MMGT2; SLC11A2; ZP3; TRPM2; SLC11A1
    protein binding EFEMP2; TRAF3IP1; LACTB2; UBQLN4; WDR92; GM885; GTF2H2; JDP2; FBXL5; EXOC4
    signal transducer activity OLFCD2; PPM1A; Sectm1a; GNAIA; TAAR12A; MRGPRB5; OLFR5; GRM2A; TAAR13E; OLFCG3
    store-operated calcium channel activity STIM2; TRPC5A; ORAI1B; ORAI1; TRPC7A; TRPC4; TRPC5; ORAI3; TRPC1; TRPC7

    ZP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZP3.

    Khosravi-Farsani, S; Amidi, F; et al. Isolation and Enrichment of Mouse Female Germ Line Stem Cells. CELL JOURNAL 16:406-415(2015).
    Kongmanas, K; Kruevaisayawan, H; et al. Proteomic Characterization of Pig Sperm Anterior Head Plasma Membrane Reveals Roles of Acrosomal Proteins in ZP3 Binding. JOURNAL OF CELLULAR PHYSIOLOGY 230:449-463(2015).

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