AARS
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Official Full Name
alanyl-tRNA synthetase
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Overview
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. -
Synonyms
AARS; alanyl-tRNA synthetase; alanine--tRNA ligase, cytoplasmic; alanine tRNA ligase 1; cytoplasmic; alaRS; renal carcinoma antigen NY-REN-42; alanine tRNA ligase 1, cytoplasmic; alanyl-tRNA synthetase, cytoplasmic; CMT2N;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf9 Insect Cell
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | AARS-51H | Recombinant Human Alanyl-tRNA Synthetase, His-tagged | Sf9 Insect Cell | His | ||
Human | AARS-9196H | Recombinant Human AARS, GST-tagged | E.coli | GST | 1-350a.a. | |
Human | AARS-241H | Recombinant Human AARS Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | AARS-757HF | Recombinant Full Length Human AARS Protein, GST-tagged | In Vitro Cell Free System | GST | 968 amino acids | |
Human | AARS-459H | Recombinant Human AARS Protein (Met1-Asn968), His-tagged | Insect Cell | His | Met1-Asn968 | |
Human | AARS-0409H | Recombinant Human AARS protein, His-tagged | E.coli | His | 1-350 aa | |
Mouse | Aars-2487M | Recombinant Mouse Aars protein(Met1-Asn968), His-tagged | Insect Cells | C-His | Met1-Asn968 | |
Mouse | AARS-521MCL | Recombinant Mouse AARS cell lysate | Insect Cell | N/A | ||
Mouse | Aars-1455M | Recombinant Mouse Aars Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Rat | AARS-386R | Recombinant Rat AARS Protein | Mammalian Cell | His | ||
Rat | Aars-3250R | Recombinant Rat Aars, His-tagged | E.Coli or Yeast | His | 968 | |
Rat | AARS-41R | Recombinant Rat AARS Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | AARS-41R-B | Recombinant Rat AARS Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | AARS-3856Z | Recombinant Zebrafish AARS | Mammalian Cell | His | ||
Chicken | AARS-1271C | Recombinant Chicken AARS | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- AARS Related Articles
AARS involved in several pathways and played different roles in them. We selected most pathways AARS participated on our site, such as Aminoacyl-tRNA biosynthesis, Cytosolic tRNA aminoacylation, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with AARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Aminoacyl-tRNA biosynthesis | EPRS;RARS;SEPSECS;MARS2;VARS;FARS2;RARS2;PET112L;NARS |
Cytosolic tRNA aminoacylation | AARS;AIMP1;FARSB;MADD;KARS;AIMP2;EEF1E1;DARS |
Gene Expression | THG1L;ZFP36L1B;TNPO1;DARS;CCNT2B;ZNF257;SF3B4;ESRRG;ZNF436 |
tRNA Aminoacylation | EARS2;KARS;DARS;AARS;FARS2;EEF1E1;AIMP1;AIMP2;WARS2 |
AARS has several biochemical functions, for example, ATP binding, alanine-tRNA ligase activity, amino acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AARS itself. We selected most functions AARS had, and list some proteins which have the same functions with AARS. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | BMP2K;CDK8;RPS6KB1;DDX51;WNK2;ATP8B5;ABCF3;SMARCAL1;GTF2F2B |
alanine-tRNA ligase activity | AARS;AARSD1;AARS2 |
amino acid binding | TH;PAH;TPH2;OTC;TPH1A;KARS;DDAH1;TDO2;AGXT |
aminoacyl-tRNA editing activity | DTD2;VARS;IARS2;LARS2;DTD1;VARS2;IARS;LARS;AARS |
metal ion binding | BTR22;PPARDB;ADAM25;DCST1;MAP2K2;ZFP513;KDM5BA;MGAT4C;ITGAE |
tRNA binding | EIF2AK4;PTCD1;TRNT1;IGHMBP2;TYW5;FARS2;TERT;METTL1;NSUN2 |
AARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AARS here. Most of them are supplied by our site. Hope this information will be useful for your research of AARS.
VCAM1; ETS1; YWHAZ; 15-deoxy-delta(12,14; ere_dna; FN1; HSP90AB1; Calml3
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