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ABAT

  • Official Full Name

    4-aminobutyrate aminotransferase

  • Overview

    4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
  • Synonyms

    ABAT; 4-aminobutyrate aminotransferase; 4-aminobutyrate aminotransferase, mitochondrial; 4 aminobutyrate transaminase; GABAT; mitochondrial; (S) 3 amino 2 methylpropionate transaminase; (S)-3-amino-2-methylpropionate transaminase; 4 aminobutyrate aminotransferase; 4 aminobutyrate aminotransferase, mitochondrial; FLJ17813; FLJ30272; GABA aminotransferase; GABA AT; GABA T; GABA transaminase; GABA transferase; GABA-AT; GABA-T; GABT_HUMAN; Gamma amino N butyrate transaminase; Gamma-amino-N-butyrate transaminase; hCG1984265; L AIBAT; L-AIBAT; LAIBAT; NPD009; 4-aminobutyrate transaminase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO|Myc
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABAT-030H Recombinant Human ABAT Protein, GST-tagged Wheat Germ GST
Human ABAT-1034H Recombinant Human ABAT protein, His & T7-tagged E.coli His/T7 Pro249~Lys500 (Accession # P80404)
Human ABAT-1106H Recombinant Human ABAT Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
Human ABAT-9154HCL Recombinant Human ABAT 293 Cell Lysate HEK293 N/A
Human ABAT-9153HCL Recombinant Human ABAT 293 Cell Lysate HEK293 N/A
Human ABAT-1795H Recombinant Human ABAT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ABAT-5532H Recombinant Human ABAT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ABAT-462H Recombinant Human ABAT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ABAT-0087H Recombinant Human ABAT Protein (Pro249-Lys500), N-His-tagged E.coli N-His Pro249-Lys500
Human ABAT-762HF Recombinant Full Length Human ABAT Protein, GST-tagged In Vitro Cell Free System GST 116 amino acids
Mouse Abat-1035M Recombinant Mouse Abat protein, His & T7-tagged E.coli His/T7 Ile236~Lys500 (Accession # P61922)
Mouse ABAT-1071M Recombinant Mouse ABAT Protein Mammalian Cell His
Mouse Abat-1459M Recombinant Mouse Abat Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat ABAT-392R Recombinant Rat ABAT Protein Mammalian Cell His
Rat ABAT-47R Recombinant Rat ABAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Abat-09R Recombinant Rat Abat Protein, His-tagged E.coli N-His Ile236-Lys500
Rat ABAT-47R-B Recombinant Rat ABAT Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ABAT-11543Z Recombinant Zebrafish ABAT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ABAT Related Articles

ABAT involved in several pathways and played different roles in them. We selected most pathways ABAT participated on our site, such as 4-aminobutanoate degradation I, 4-aminobutyrate degradation, Alanine and aspartate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
4-aminobutanoate degradation I
4-aminobutyrate degradation
Alanine and aspartate metabolismDARS;AGXT;ABAT
Alanine, aspartate and glutamate metabolismAGXT2;GLULB;GLULC;ybaS;ALDH4A1;GLUL;CAD;GLS;NAT8L
Butanoate metabolismBDH1;ABAT;HMGCS1;HADHAA;HMGCS2;BDH2;ACSM3;ALDH5A1;OXCT2B
Degradation of GABA
GABA shunt
GABA synthesis, release, reuptake and degradationSLC6A1A;CPLX2L;STXBP1A;SYT1A;SLC6A12;SNAP25B;RAB3AB;SLC6A1B;CPLX1

ABAT has several biochemical functions, for example, (S)-3-amino-2-methylpropionate transaminase activity, contributes_to 4-aminobutyrate transaminase activity, 4-aminobutyrate transaminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABAT itself. We selected most functions ABAT had, and list some proteins which have the same functions with ABAT. You can find most of the proteins on our site.

Function Related Protein
(S)-3-amino-2-methylpropionate transaminase activity
contributes_to 4-aminobutyrate transaminase activity
4-aminobutyrate transaminase activity
iron-sulfur cluster bindingNFS1;FDX1B;ISCUB;REV3L;PROZA;AOX3;ELP3;AOX4;FXN
metal ion bindingZFP41;PIR;DMRTC2;ZMYND19;ZBTB6;RNASEH2A;GUCA1D;NEK3;ZBED1
protein homodimerization activityCBX1;CCDC103;SIAH1A;ZBTB1;HMOX1;LRRFIP1;LRRK2;CADM1;BHLHE40
pyridoxal phosphate bindingGOT1L1;SDSL;CTHL;CCBL1;SDS;SPTLC1;SPTLC2;HDC;CTH
succinate-semialdehyde dehydrogenase binding

ABAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABAT here. Most of them are supplied by our site. Hope this information will be useful for your research of ABAT.

CRK; ere_dna

Hallinen, TA; Soini, EJO; et al. Cost-utility of different treatment strategies after the failure of tumour necrosis factor inhibitor in rheumatoid arthritis in the Finnish setting. RHEUMATOLOGY 49:767-777(2010).
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