Recombinant Human ABAT Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : ABAT-462H
Product Overview : ABAT MS Standard C13 and N15-labeled recombinant protein (NP_065737) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 56.5 kDa
AA Sequence : MASMLLAQRLACSFQHSYRLLVPGS RHISQAAAKVDVEFDYDGPLMKTEV PGPRSRELMKQLNIIQNAEAVHFFC NYEESRGNYLVDVDGNRMLDLYSQI SSVPIGYSHPALLKLIQQPQNASMF VNRPALGILPPENFVEKLRQSLLSV APKGMSQLITMACGSCSNENALKTI FMWYRSKERGQRGFSQEELETCMIN QAPGCPDYSILSFMGAFHGRTMGCL ATTHSKAIHKIDIPSFDWPIAPFPR LKYPLEEFVKENQQEEARCLEEVED LIVKYRKKKKTVAGIIVEPIQSEGG DNHASDDFFRKLRDIARKHGCAFLV DEVQTGGGCTGKFWAHEHWGLDDPA DVMTFSKKMMTGGFFHKEEFRPNAP YRIFNTWLGDPSKNLLLAEVINIIK REDLLNNAAHAGKALLTGLLDLQAR YPQFISRVRGRGTFCSFDTPDDSIR NKLILIARNKGVVLGGCGDKSIRFR PTLVFRDHHAHLFLNIFSDILADFK TRTRPLEQKLISEEDLAANDILDYK DDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : ABAT 4-aminobutyrate aminotransferase [ Homo sapiens (human) ]
Official Symbol : ABAT
Synonyms : ABAT; 4-aminobutyrate aminotransferase; 4-aminobutyrate aminotransferase, mitochondrial; 4 aminobutyrate transaminase; GABAT; GABA transferase; GABA transaminase; GABA aminotransferase; 4-aminobutyrate transaminase; gamma-amino-N-butyrate transaminase; (S)-3-amino-2-methylpropionate transaminase; NPD009; GABA-AT; FLJ17813; FLJ30272;
Gene ID : 18
mRNA Refseq : NM_020686
Protein Refseq : NP_065737
MIM : 137150
UniProt ID : P80404

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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