ABCA1
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Official Full Name
ATP-binding cassette, sub-family A (ABC1), member 1
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Overview
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangiers disease and familial high-density lipoprotein deficiency. -
Synonyms
ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1; ABC1, HDLDT1; ATP-binding cassette sub-family A member 1; Tangier disease; TGD; membrane-bound; ATP-binding cassette transporter 1; ATP-binding cassette transporter A1; cholesterol efflux regulat;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- E.Coli or Yeast
- HEK293
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Flag
- StrepII
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ABCA1-178H | Recombinant Human ABCA1 protein, GST-tagged | Wheat Germ | GST | 86-185 |
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| Human | ABCA1-459H | Recombinant Human ABCA1 | Mammalian Cell | His |
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| Human | ABCA1-5857H | Recombinant Human ABCA1 protein, His-tagged | E.coli | His | Asn1385~Phe1663 |
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| Human | ABCA1-0286H | Recombinant Human ABCA1 Protein (A2-V2261), Flag, Strep II, 8×His tagged | Insect Cell | His&Flag&StrepII | A2-V2261 |
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| Human | ABCA1-2398H-B | Recombinant Human ABCA1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Human | ABCA1-3140H | Recombinant Human ABCA1 protein, His-tagged | E.coli | His | 106-305 aa | |
| Human | ABCA1-10H | Recombinant Human ABCA1 Protein, His-tagged | E.coli | His | Arg43-Glu450 |
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| Human | ABCA1-2398H | Recombinant Human ABCA1 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Human | ABCA1-0185H | Recombinant Human ABCA1 Protein (Ser45-Glu271), N-His-tagged | E.coli | His | Ser45-Glu271 |
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| Human | ABCA1-2493H | Recombinant Human ABCA1 protein(1171-1280 aa), C-His-tagged | E.coli | His | 1171-1280 aa |
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| Mouse | ABCA1-3696M | Recombinant Mouse ABCA1, His-tagged | E.coli | His | 2261 |
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| Mouse | Abca1-3728M | Recombinant Mouse Abca1, His-tagged | E.Coli or Yeast | His | 2261 |
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| Chicken | ABCA1-5721C | Recombinant Chicken ABCA1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ABCA1 involved in several pathways and played different roles in them. We selected most pathways ABCA1 participated on our site, such as ABC transporters, Fat digestion and absorption, Fatty acid, triacylglycerol, and ketone body metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCB10;ABCC9;ABCC12;TAP1;ABCD2;ABCB3L1;ABCC8;ABCA1;ABCA7 |
| Fat digestion and absorption | PLA2G5;Cel;FABP1;MTTP;SLC27A4;GOT2;MOGAT2;FABP2;ABCA1 |
| Fatty acid, triacylglycerol, and ketone body metabolism | MED29;ACOT9.2;GLIPR1;AGPAT1;TMEM195;MED10;MED20;ESRRA;HELZ2 |
| Folate Metabolism | AHCY;SAA4;SAA2;SAA1;ABCA1;SAA2-SAA4 |
| HDL-mediated lipid transport | BMP1A;Alb;ABCA1;APOC2;CETP;APOA1B;AMN |
| Lipid digestion, mobilization, and transport | FABP11B;APOEA;FABP9;APOA1B;FABP1B.1;FABP12;APOA4B.1;APOEB;MTP |
| Lipoprotein metabolism | APOEB;APOA1B;APOA4B.2;APOA4B.1;ABCA1;APOEA;APOBB.1;CETP;MTP |
| Metabolism | COX11;LSM1;ACOT11A;SLCO1B1;Gpc2;PLIN2;B3GAT2;BRP44;CYP2K16 |
ABCA1 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, ATPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA1 itself. We selected most functions ABCA1 had, and list some proteins which have the same functions with ABCA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MADD;PANK1B;SGK3;ADCK2;MTHFD1;PFKL;AK5;CDK8;CAMKK1A |
| ATPase activity, coupled to transmembrane movement of substances | ABCB6A;IPO8;ABCC1;ABCB4;ABCC6;ABCA9;ABCC8;ABCA4A;ABCG3 |
| ATPase binding | SYVN1;DNAJB1;ABCA1;ANK1;ALDOB;EZR;ATPIF1A;ATP6V0A2B;CHMP4A |
| anion transmembrane transporter activity | SLC4A11;SLC4A4A;SLC4A1B;ABCA1;SLC4A8;SLC4A2B;SLC26A11;SLC4A2A;SLC4A1A |
| apolipoprotein A-I binding | LCAT;ABCA1B;SCARB1;ABCA1 |
| apolipoprotein A-I receptor activity | ABCA1;ABCA7 |
| apolipoprotein binding | VLDLR;LPL;PCSK9;PLG;LRP4;LRP6;MAPT;LIPC;ABCA1 |
| cholesterol binding | ERLIN2;CYP11A1;ABCG1;ERLIN1;APOA4B.1;NPC2;APOC3;ABCA1;PTCH1 |
| cholesterol transporter activity | ABCA4A;APOA4B.1;ABCA1B;APOA1A;ABCA7;APOB;STAR;APOA4;ABCA1 |
| phospholipid binding | PLA2G7;MTAP1B;SPTB;LPAR3;BIN2;PACSIN1A;SYTL4;NBEA;ESYT1 |
| phospholipid transporter activity | MFSD2AA;ABCA4;CETP;MFSD2AB;OSBPL8;ATP8B5;ABCA7;MTTP;ABCG1 |
| protein binding | CDC7;CXCR5;SEMA4D;AGPAT5;SAP18;CLEC7A;LANCL2;UBE2G2;CDKN1C |
| receptor binding | FGF1B;ANXA1;Itga10&Itgb1;CSK;CSNK2B;ADIPOQ;GSTK1;SRPX2;RIPK2 |
| small GTPase binding | PEX5;FLNA;RNF152;FGD2;FGD4;FGD1;ERRFI1;FGD3;ABCA1 |
| syntaxin binding | TXLNA;VAMP2;ABL1;SYT11;SYT11B;SYT7B;STX6;SYT9B;SYT2 |
ABCA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA1.
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Customer Reviews (7)
Write a reviewWork great in Western blot analysis.
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Great recombinant protein product. The instruction manual attached to the product is detailed and provided me with some help.
Useful in structure analysis.
I purchased ABCA1 protein as a positive reference for western blot and got clear and distinct bands.
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Q&As (10)
Ask a questionWe have multiple protein expression platforms, including baculovirus-insect cell expression systems, bacterial expression systems (E. coli / Bacillus), mammalian expression systems, yeast expression systems (P pastoris / S cerevisiae), Nicotiana tabacum specific expression platform.
You can try to optimize the protocol for preparing stacking gel and running gel. Appropriately prolonging the running gel polymerization time and completely removing water before pouring into the stacking gel are directions that can be optimized.
Both trehalose and mannitol are added as lyoprotectants, which can significantly prevent protein structure changes, elongation and aggregation during freeze-drying.
Removing labels may affect product stability. If you really need to remove the label, please contact us, we will customize the recombinant protein product according to your needs.
Generally, recombinant proteins expressed by prokaryotic cells are in the state of lyophilized powder and need to be dissolved before use. However, the recombinant protein expressed by eukaryotic cells is more conducive to maintaining its activity and stability when stored in a solution state.
ABCA1 protein is mainly located in the cell membrane.
You can try to use 8%PAGE.
ABCA1 is a membrane protein, and it is necessary to avoid protein damage during sample processing. You may need to further optimize the sample handling process.
You can contact our technical experts directly by email or phone, and they will give you relevant advice.
It is recommended to check whether the antibody is suitable, including the specificity and concentration settings.
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