ABCB4
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Official Full Name
ATP-binding cassette, sub-family B (MDR/TAP), member 4
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Overview
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.ABC proteins transport various molecules across extra- and intra-cellular membranes.ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).This protein is a member of the MDR/TAP subfamily.Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation.This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate.The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile.Alternative splicing of this gene results in several products of undetermined function. -
Synonyms
ABCB4; ATP-binding cassette, sub-family B (MDR/TAP), member 4; MDR3, PGY3; multidrug resistance protein 3; GBD1; MDR2; PFIC 3; P-glycoprotein 3; multiple drug resistance 3; ATP-binding cassette sub-family B member 4; P glycoprotein 3/multiple drug resistance 3; P-glycoprotein-3/multiple drug resistance-3; MDR3; PGY3; ABC21; MDR2/3; PFIC-3;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Dictyostelium discoideum (Slime mold)
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- His|T7
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ABCB4-301507H | Recombinant Human ABCB4 protein, GST-tagged | E.coli | GST | Val628-Thr706 |
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| Human | ABCB4-11H | Recombinant Human ABCB4 Protein, His-tagged | E.coli | N-His | Ile1034-Leu1286 |
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| Mouse | ABCB4-1091M | Recombinant Mouse ABCB4 Protein | Mammalian Cell | His |
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| Mouse | Abcb4-8124M | Recombinant Mouse Abcb4 protein, His & T7-tagged | E.coli | His/T7 | Asn1034~Leu1276 (Accession # P21440) |
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| Mouse | ABCB4-301M | Recombinant Mouse ABCB4 Protein (352-708 aa), GST-tagged | E.coli | GST | 352-708 aa |
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| Mouse | ABCB4-189M | Recombinant Mouse ABCB4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | ABCB4-189M-B | Recombinant Mouse ABCB4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ABCB4-397R | Recombinant Rat ABCB4 Protein | Mammalian Cell | His |
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| Rat | ABCB4-52R | Recombinant Rat ABCB4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | ABCB4-52R-B | Recombinant Rat ABCB4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Dictyostelium discoideum (Slime mold) | RFL26679DF | Recombinant Full Length Dictyostelium Discoideum Abc Transporter B Family Member 4(Abcb4) Protein, His-Tagged | E.coli expression system | His | Full Length (1-767) |
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| Zebrafish | ABCB4-6449Z | Recombinant Zebrafish ABCB4 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ABCB4 Related Articles
ABCB4 involved in several pathways and played different roles in them. We selected most pathways ABCB4 participated on our site, such as ABC transporters, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | SUR2A;ABCD4;ABCB3L1;ABCC10;ABCA9;ABCC2;ABCB4;ABCB10;ABCB6A |
| Bile secretion | GNAS;Abcb1b;RXRA;ABCG2;ADCY6;ABCB4;SLCO1A5;ATP1B2;ABCG8 |
ABCB4 has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled to transmembrane movement of substances. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCB4 itself. We selected most functions ABCB4 had, and list some proteins which have the same functions with ABCB4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PRKACA;INO80;RBKS;TNIKA;CDK11A;CSNK2A2A;CCC2;DGKA;DGKD |
| ATPase activity | KIF2B;CLPX;DYNC2H1;HSPA5;WRNIP1;CHD1L;ATAD1A;DNAH11;KIF23 |
| ATPase activity, coupled to transmembrane movement of substances | ABCC1;ATP6V1D;Abcb1b;SFRP5;ABCC12;ABCB3L1;IPO8;ABCA9;ABCA5 |
| hydrolase activity | CTSSB.2;Casp3;IHHB;FAM105B;PTPN11A;CHD9;CASPBL;CAPN12;ACOT5 |
| nucleotide binding | PKN1B;cka1;RALY;CLCN3;AGAP2;FGFR1A;CKMB;HNRNPA0B;CLCN4-2 |
| phosphatidylcholine transporter activity | ABCB4;PITPNA;PITPNBL;PCTP |
| phosphatidylcholine-translocating ATPase activity | |
| xenobiotic-transporting ATPase activity | ABCB1;ABCB4;ABCB1A;ABCG2;Abcb1b |
ABCB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCB4.
- Q&As
- Reviews
Q&As (10)
Ask a questionThe endotoxin level of recombinant protein can be customized according to customer needs, and you can communicate with our technical experts in detail.
We provide these two types of recombinant proteins, you can buy or customize according to your needs.
We provide recombinant protein products with different purities, and you can communicate with our technical experts about your customized needs.
Both have their own advantages, and the freeze-dried form is more stable than the liquid form, but the freeze-drying process may cause certain damage to the structure and activity of the protein.
Bile contains three main lipids: cholesterol, phospholipids and bile acids. ABCB4 protein participates in phospholipid transport and is crucial for the formation of bile.
ABCB4 protein is also known as multidrug resistance protein 3 (MDR3).
It is generally recommended to incubate at room temperature for about two hours, but the exact time may also vary.
Quantification can be performed in the linear range of detection using ImageJ software.
If you have requirements for the product format, please note when placing an order.
You can use the Uptima bicinchoninic acid protein assay to determine the protein concentrations.
Customer Reviews (2)
Write a reviewI purchased this protein product for Western blotting, and the feedback results are not bad, and it can meet my experimental needs.
I have received my customized recombinant ABCB4 protein, and the delivery cycle is short
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