Recombinant Mouse ABCB4 Protein (352-708 aa), GST-tagged

PRODUCTS

Home / Products / Recombinant Proteins / Recombinant Mouse ABCB4 Protein (352-708 aa), GST-tagged

Recombinant Mouse ABCB4 Protein (352-708 aa), GST-tagged

ABCB4 Related Products

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

Cat.No. : ABCB4-301M
Product Overview : Recombinant Mouse ABCB4 Protein (352-708 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Protein Description: Partial.
Description : Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:8106172, PubMed:7912658, PubMed:7592705, PubMed:7814632, PubMed:8725158, PubMed:9366571). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes (By similarity). Required for proper phospholipid bile formation (PubMed:8106172). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:7814632, PubMed:8725158). May promote biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance (PubMed:1990275).
Source : E. coli
Species : Mouse
Tag : GST
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 66.6 kDa
Protein length : 352-708 aa
AA Sequence : DAFANARGAA YVIFDIIDNN PKIDSFSERG HKPDNIKGNL EFSDVHFSYP SRANIKILKG LNLKVKSGQT VALVGNSGCG KSTTVQLLQR LYDPTEGKIS IDGQDIRNFN VRCLREIIGV VSQEPVLFST TIAENIRYGR GNVTMDEIEK AVKEANAYDF IMKLPQKFDT LVGDRGAQLS GGQKQRIAIA RALVRNPKIL LLDEATSALD TESEAEVQAA LDKAREGRTT IVIAHRLSTI RNADVIAGFE DGVIVEQGSH SELMKKEGIY FRLVNMQTAG SQILSEEFEV ELSDEKAAGD VAPNGWKARI FRNSTKKSLK SPHQNRLDEE TNELDANVPP VSFLKVLKLN KTEWPYF
Purity : > 90% as determined by SDS-PAGE
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 [ Mus musculus ]
Official Symbol : ABCB4
Synonyms : ABCB4; P glycoprotein 2; P-glycoprotein 3; Mdr2; Pgy2; Pgy-2; mdr-2;
Gene ID : 18670
mRNA Refseq : NM_008830
Protein Refseq : NP_032856

Online Inquiry


  • Note: There will be extra charge for optional service!
  • Verification Code Please review Creative BioMart's privacy policy for more information

Optional Service: Optional requirements on this protein

Other Requirements:

Apply For A Coupon

$50 OFF Your First Purchase

Apply For a Coupon

Enter your email here to subscribe.

creative biomart inc.

Easy access to products and services you need from our library via powerful searching tools.

Follow Us

Copyright © 2007 – 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy