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ABHD12

  • Official Full Name

    abhydrolase domain containing 12

  • Overview

    This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
  • Synonyms

    ABHD12; abhydrolase domain containing 12; C20orf22, chromosome 20 open reading frame 22; monoacylglycerol lipase ABHD12; ABHD12A; BEM46L2; dJ965G21.2; DKFZP434P106; 6330583M11Rik; AI431047; AW547313; RP23-241M12.2; Abhydrolase domain containing protein 12; C20orf22; 2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 12; PHARC;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • Zebrafish
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ABHD12-073H Recombinant Human ABHD12 Protein, GST-Tagged Wheat Germ GST
Human ABHD12-9HCL Recombinant Human ABHD12 cell lysate N/A
Human ABHD12-1002HFL Recombinant Full Length Human ABHD12 Protein, C-Flag-tagged Mammalian cells Flag
Human ABHD12-828HF Recombinant Full Length Human ABHD12 Protein, GST-tagged In Vitro Cell Free System GST 404 amino acids
Human ABHD12-1214H Recombinant Human ABHD12 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ABHD12-247H-B Recombinant Human ABHD12 Protein Pre-coupled Magnetic Beads HEK293
Human ABHD12-247H Recombinant Human ABHD12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ABHD12-1123M Recombinant Mouse ABHD12 Protein Mammalian Cell His
Mouse Abhd12-1467M Recombinant Mouse Abhd12 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ABHD12-212M-B Recombinant Mouse ABHD12 Protein Pre-coupled Magnetic Beads HEK293
Mouse ABHD12-212M Recombinant Mouse ABHD12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ABHD12-418R Recombinant Rat ABHD12 Protein Mammalian Cell His
Rat ABHD12-73R Recombinant Rat ABHD12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ABHD12-73R-B Recombinant Rat ABHD12 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey ABHD12-262C Recombinant Cynomolgus ABHD12 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ABHD12-12C-B Recombinant Cynomolgus Monkey ABHD12 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey ABHD12-12C Recombinant Cynomolgus Monkey ABHD12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ABHD12-186R Recombinant Rhesus monkey ABHD12 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ABHD12-15R-B Recombinant Rhesus Macaque ABHD12 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ABHD12-15R Recombinant Rhesus Macaque ABHD12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL-17285XF Recombinant Full Length Xenopus Tropicalis Monoacylglycerol Lipase Abhd12(Abhd12) Protein, His-Tagged E.coli expression system His Full Length (1-386)
Zebrafish ABHD12-4493Z Recombinant Zebrafish ABHD12 Mammalian Cell His
Chicken ABHD12-2089C Recombinant Chicken ABHD12 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ABHD12 Related Articles

ABHD12 involved in several pathways and played different roles in them. We selected most pathways ABHD12 participated on our site, such as Arachidonate production from DAG, Effects of PIP2 hydrolysis, G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABHD12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonate production from DAGABHD6B;MGLL;ABHD12
Effects of PIP2 hydrolysisMGLL;TRPC7;TRPC6A;DGKA;ABHD12;DGKB;TRPC3;PRKCHB;TAE1
G alpha (q) signalling eventsARHGEF25;RGS21;GPR4;NPSR1;OPN4B;DGKA;GPR132;MGLL;UTS2
GPCR downstream signalingRLN2;CHRM1;NTS;GCGA;CCL35.2;ANXA1;OPN4B;TAS2R16;NMU
Gastrin-CREB signalling pathway via PKC and MAPKPROKR1;PMCH;NMS;TRPC3;GPR4;QRFP;PROK1;CCK;NMB
HemostasisCABLES2;MMRN2A;F9A;F11R.2;AKAP1B;SLC16A8;MFN2;APOER2;CENPE
Platelet activation, signaling and aggregationGAS6;F13A1B;ABHD12;CAP1;CLU;FCER1GL;CALU;CLEC1B;CD9A
Signal TransductionSEPT7;RNF41;GPR55;RGS21;ARHGAP33;RHPN1;SKIB;SHB;NPFF

ABHD12 has several biochemical functions, for example, acylglycerol lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABHD12 itself. We selected most functions ABHD12 had, and list some proteins which have the same functions with ABHD12. You can find most of the proteins on our site.

Function Related Protein
acylglycerol lipase activityABHD12;PNLIPRP2;FAAH;ABHD6;MGLL

ABHD12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABHD12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABHD12.

P

Kamat, SS; Camara, K; et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. NATURE CHEMICAL BIOLOGY 11:164-U116(2015).
Wortmann, SB; Espeel, M; et al. Inborn errors of metabolism in the biosynthesis and remodelling of phospholipids. JOURNAL OF INHERITED METABOLIC DISEASE 38:99-110(2015).
  • Q&As
  • Reviews

Q&As (10)

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Where (which organs) does the ABHD12 overexpress? 03/19/2022

This gene is overexpressed in nasal epithelium and bone.

What is the mechanism action of the ABHD12 in the drug called Orlistat? 02/27/2022

Lipase inhibitor for obesity treatment, Small Molecule, Anti-Obesity Agents, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity

List at least three biological process for ABHD12 gene? 10/12/2021

Phospholipid catabolic process, Lipid metabolic process, and Protein depalmitoylation.

What are the top five Interacting proteins for ABHD12 gene? 09/12/2021

They are DPP9, HSCB, COASY, SLC39A4, and SRSF1.

List at least three reactome pathways for ABHD12 gene? 08/11/2020

Arachidonate production from DAG, Effects of PIP2 hydrolysis, and GPCR downstream signalling.

How to determine the corelation between breast cancer and the ABHD12 expression? 04/18/2020

It can be determined by analysing ABHD12 mRNA expression in breast cancer tissues and healthy tissues, based on a series of research, we found that mRNA expression profile revealed that the ABHD12 transcript is highly expressed in tissues of patients with breast cancer compared to that expressed in healthy tissues adjacent to tumour.

What will happen if the ABHD12 was disrupted in mice ? 03/11/2020

Disruption of ABHD12 in mice leads to (i) accumulation of lyso-PS in the cerebellum breaching the homeostatic threshold, inducing continuous stimulation of the Purkinje neurons, leading to deregulated cerebellar activity and (ii) increased levels of microglial activation and inflammation. Accompanying this inflammatory response in mice are behavioral deficits, including sensorimotor defects and hearing loss.

Brefily introduce a molecular function of ABHD12? 07/07/2019

Lysophosphatidylserine (i.e. ABHD12) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes, represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system.

What disease will occur if the ABHD12 mutate? 01/08/2019

Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract)

Why ABHD12 mutation can results of a series of neurodegenerative diseases? 12/14/2018

It is because this gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation

Customer Reviews (3)

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Reviews
06/10/2020

    The product description covers all product attributes and application methods, and will repurchase.

    02/27/2020

      The packaging is intact with clear labels, cool.

      09/12/2019

        Reasonable price!

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