ABHD12
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Official Full Name
abhydrolase domain containing 12
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Overview
This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. -
Synonyms
ABHD12; abhydrolase domain containing 12; C20orf22, chromosome 20 open reading frame 22; monoacylglycerol lipase ABHD12; ABHD12A; BEM46L2; dJ965G21.2; DKFZP434P106; 6330583M11Rik; AI431047; AW547313; RP23-241M12.2; Abhydrolase domain containing protein 12; C20orf22; 2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 12; PHARC;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
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- Rhesus Macaque
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Zebrafish
- E.coli expression system
- HEK293
- HEK293T
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- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ABHD12 Related Articles
ABHD12 involved in several pathways and played different roles in them. We selected most pathways ABHD12 participated on our site, such as Arachidonate production from DAG, Effects of PIP2 hydrolysis, G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABHD12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Arachidonate production from DAG | ABHD6B;MGLL;ABHD12 |
Effects of PIP2 hydrolysis | MGLL;TRPC7;TRPC6A;DGKA;ABHD12;DGKB;TRPC3;PRKCHB;TAE1 |
G alpha (q) signalling events | ARHGEF25;RGS21;GPR4;NPSR1;OPN4B;DGKA;GPR132;MGLL;UTS2 |
GPCR downstream signaling | RLN2;CHRM1;NTS;GCGA;CCL35.2;ANXA1;OPN4B;TAS2R16;NMU |
Gastrin-CREB signalling pathway via PKC and MAPK | PROKR1;PMCH;NMS;TRPC3;GPR4;QRFP;PROK1;CCK;NMB |
Hemostasis | CABLES2;MMRN2A;F9A;F11R.2;AKAP1B;SLC16A8;MFN2;APOER2;CENPE |
Platelet activation, signaling and aggregation | GAS6;F13A1B;ABHD12;CAP1;CLU;FCER1GL;CALU;CLEC1B;CD9A |
Signal Transduction | SEPT7;RNF41;GPR55;RGS21;ARHGAP33;RHPN1;SKIB;SHB;NPFF |
ABHD12 has several biochemical functions, for example, acylglycerol lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ABHD12 itself. We selected most functions ABHD12 had, and list some proteins which have the same functions with ABHD12. You can find most of the proteins on our site.
Function | Related Protein |
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acylglycerol lipase activity | ABHD12;PNLIPRP2;FAAH;ABHD6;MGLL |
ABHD12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABHD12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABHD12.
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- Q&As
- Reviews
Q&As (10)
Ask a questionThis gene is overexpressed in nasal epithelium and bone.
Lipase inhibitor for obesity treatment, Small Molecule, Anti-Obesity Agents, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity
Phospholipid catabolic process, Lipid metabolic process, and Protein depalmitoylation.
They are DPP9, HSCB, COASY, SLC39A4, and SRSF1.
Arachidonate production from DAG, Effects of PIP2 hydrolysis, and GPCR downstream signalling.
It can be determined by analysing ABHD12 mRNA expression in breast cancer tissues and healthy tissues, based on a series of research, we found that mRNA expression profile revealed that the ABHD12 transcript is highly expressed in tissues of patients with breast cancer compared to that expressed in healthy tissues adjacent to tumour.
Disruption of ABHD12 in mice leads to (i) accumulation of lyso-PS in the cerebellum breaching the homeostatic threshold, inducing continuous stimulation of the Purkinje neurons, leading to deregulated cerebellar activity and (ii) increased levels of microglial activation and inflammation. Accompanying this inflammatory response in mice are behavioral deficits, including sensorimotor defects and hearing loss.
Lysophosphatidylserine (i.e. ABHD12) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes, represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system.
Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract)
It is because this gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation
Customer Reviews (3)
Write a reviewThe product description covers all product attributes and application methods, and will repurchase.
The packaging is intact with clear labels, cool.
Reasonable price!
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