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Recombinant Mouse ABHD12 Protein

Cat.No. : ABHD12-1123M
Product Overview : Recombinant Mouse ABHD12 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Abhd12 abhydrolase domain containing 12 [ Mus musculus ]
Official Symbol : ABHD12
Gene ID : 76192
mRNA Refseq : NM_024465.3
Protein Refseq : NP_077785.2
MIM :
UniProt ID : Q99LR1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Where (which organs) does the ABHD12 overexpress? 03/19/2022

This gene is overexpressed in nasal epithelium and bone.

What is the mechanism action of the ABHD12 in the drug called Orlistat? 02/27/2022

Lipase inhibitor for obesity treatment, Small Molecule, Anti-Obesity Agents, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity

List at least three biological process for ABHD12 gene? 10/12/2021

Phospholipid catabolic process, Lipid metabolic process, and Protein depalmitoylation.

What are the top five Interacting proteins for ABHD12 gene? 09/12/2021

They are DPP9, HSCB, COASY, SLC39A4, and SRSF1.

List at least three reactome pathways for ABHD12 gene? 08/11/2020

Arachidonate production from DAG, Effects of PIP2 hydrolysis, and GPCR downstream signalling.

How to determine the corelation between breast cancer and the ABHD12 expression? 04/18/2020

It can be determined by analysing ABHD12 mRNA expression in breast cancer tissues and healthy tissues, based on a series of research, we found that mRNA expression profile revealed that the ABHD12 transcript is highly expressed in tissues of patients with breast cancer compared to that expressed in healthy tissues adjacent to tumour.

What will happen if the ABHD12 was disrupted in mice ? 03/11/2020

Disruption of ABHD12 in mice leads to (i) accumulation of lyso-PS in the cerebellum breaching the homeostatic threshold, inducing continuous stimulation of the Purkinje neurons, leading to deregulated cerebellar activity and (ii) increased levels of microglial activation and inflammation. Accompanying this inflammatory response in mice are behavioral deficits, including sensorimotor defects and hearing loss.

Brefily introduce a molecular function of ABHD12? 07/07/2019

Lysophosphatidylserine (i.e. ABHD12) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes, represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system.

What disease will occur if the ABHD12 mutate? 01/08/2019

Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract)

Why ABHD12 mutation can results of a series of neurodegenerative diseases? 12/14/2018

It is because this gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation

Customer Reviews (3)

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Reviews
06/10/2020

    The product description covers all product attributes and application methods, and will repurchase.

    02/27/2020

      The packaging is intact with clear labels, cool.

      09/12/2019

        Reasonable price!

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