ACAD8
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Official Full Name
acyl-CoA dehydrogenase family, member 8
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Overview
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency. -
Synonyms
ACAD8; acyl-CoA dehydrogenase family, member 8; acyl Coenzyme A dehydrogenase family, member 8; isobutyryl-CoA dehydrogenase, mitochondrial; ACAD 8; Activator-recruited cofactor 42 kDa component; Acyl CoA dehydrogenase family member 8; Acyl Coenzyme A dehydrogenase family member 8; ARC42; FLJ22590; IBD; acyl-Coenzyme A dehydrogenase family, member 8; ACAD-8;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- ACAD8 Related Articles
ACAD8 involved in several pathways and played different roles in them. We selected most pathways ACAD8 participated on our site, such as Valine, leucine and isoleucine degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAD8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Valine, leucine and isoleucine degradation | ALDH6A1;ALDH3A2;ACAA2;HIBADH;ACAA1A;OXCT1B;HMGCS1;MUT;HSD17B10 |
| Metabolic pathways | PIGQ;CDIPT;AMY2A2;CBS;CES1;ZNF408;POLR3GL;NDUFS6;GPT2L |
ACAD8 has several biochemical functions, for example, acyl-CoA dehydrogenase activity, electron carrier activity, fatty-acyl-CoA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAD8 itself. We selected most functions ACAD8 had, and list some proteins which have the same functions with ACAD8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acyl-CoA dehydrogenase activity | ACADSB;GCDHA;ACADS;ACOXL;ETFA;ACADVL;ACADL;ACAD8;GCDHB |
| electron carrier activity | ALDH2;GCDH;FDX1L;AOX3;LOXL2;AOC2;PTGES2;CIAPIN1;GCDHA |
| fatty-acyl-CoA binding | ACOX2;ACBD3;ACADM;PECI;HMGCL;GCDHA;ACADS;GCDH;ACBD5 |
| flavin adenine dinucleotide binding | PPOX;SQLEA;GCDH;NDOR1;CHDH;DLDH;AOX3;ACADS;MAOB |
| oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor | ACOX3;ACAD8;ACADSB;IVD;ACADVL;ACAD9;GCDH;GCDHA;ETFA |
ACAD8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAD8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAD8.
Nek2; ETS1; TSG101; IPO8; CKAP5; Tgfbr1; LDHD; DLG3
- Q&As
- Reviews
Q&As (10)
Ask a questionThe primary structure of acyl-CoA dehydrogenase family member 8 protein consists of a chain of amino acids.
There are no known drugs or compounds that specifically target acyl-CoA dehydrogenase family member 8 protein for therapeutic purposes.
Acyl-CoA dehydrogenase family member 8 protein is involved in multiple biochemical pathways.
The three-dimensional structure of acyl-CoA dehydrogenase family member 8 protein is currently unknown.
The molecular weight of acyl-CoA dehydrogenase family member 8 protein is approximately 75 kDa.
The function of acyl-CoA dehydrogenase family member 8 protein is involved in fatty acid metabolism.
There are genetic variations or mutations in acyl-CoA dehydrogenase family member 8 protein associated with disease susceptibility.
Acyl-CoA dehydrogenase family member 8 protein is expressed in various human tissues.
There are known interacting proteins or molecules of acyl-CoA dehydrogenase family member 8 protein.
The role of acyl-CoA dehydrogenase family member 8 protein in human diseases is currently being studied.
Customer Reviews (2)
Write a reviewShows excellent performance in detecting and measuring the activity of phosphatases in phosphatase assays.
Highly effective in detecting and quantifying the expression levels of fusion proteins in protein expression analysis.
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