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Official Full Name alkaline ceramidase 1
Background Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum;corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can;trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and;sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers;regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at;the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is;highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine;(Houben et al., 2006 (PubMed 16477081); Sun et al., 2008 (PubMed 17713573)).
Synonyms ACER1; alkaline ceramidase 1; ASAH3, N acylsphingosine amidohydrolase (alkaline ceramidase) 3; alkCDase 1; alkaline CDase 1; acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3; N-acylsphingosine amidohydrolase (alkaline ceramidase) 3; ASAH3
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ACER1-9093HCL Recombinant Human ACER1 293 Cell Lysate HEK293 N/A
    Human ACER1-9287H Recombinant Human ACER1, GST-tagged E.coli GST
    Mouse ACER1-1185M Recombinant Mouse ACER1 Protein Mammalian Cell His
    Mouse Acer1-1494M Recombinant Mouse Acer1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Zebrafish ACER1-2376Z Recombinant Zebrafish ACER1 Mammalian Cell His

    acer1 involved in several pathways and played different roles in them. We selected most pathways acer1 participated on our site, such as Metabolic pathways, Metabolism, Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with acer1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolic pathways ACOT5; PLCH1; ALOX12B; CTPS1A; NSDHL; CYP3A25; LIPG; HYAL6; ALG5; H2-KE6
    Metabolism of lipids and lipoproteins APOA4B.2; CYP2AD2; CDK19; GLTPA; CPNE3; PTGDSA; ACER1; CHAT; AKR1C4; PEMT
    Sphingolipid de novo biosynthesis COL4A3BP; ACER1; SPTLC1; CERS3B; PPM1LA; PPM1LB; OSBP; SGMS2; CERS5; FA2H
    Sphingolipid metabolism KDSR; LASS5; CERS1; ASAH1B; GBA2; CERS5; UGT8; PPM1LB; GALC; PPAP2C
    Sphingolipid signaling pathway MAPK8; MAPK9; CERS5; KRAS; TNF; S1PR4; FCER1A; S1PR5; MAPK1; NOS3
    sphingosine and sphingosine-1-phosphate metabolism PTGR1; ACER1

    acer1 has several biochemical functions, for example, ceramidase activity, dihydroceramidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by acer1 itself. We selected most functions acer1 had, and list some proteins which have the same functions with acer1. You can find most of the proteins on our site.

    Function Related Protein
    ceramidase activity ASAH1; ASAH2; ASAH1B; ACER1
    dihydroceramidase activity ACER1

    acer1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with acer1 here. Most of them are supplied by our site. Hope this information will be useful for your research of acer1.

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