ACP2
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Official Full Name
acid phosphatase 2, lysosomal
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Overview
This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Mutations in this gene or in the related alpha subunit gene cause acid phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
ACP2; acid phosphatase 2, lysosomal; lysosomal acid phosphatase; LAP;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rattus norvegicus (Rat)
- Xenopus laevis (African clawed frog)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Myc
- DDK
- MYC
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ACP2-179H | Recombinant Human ACP2 Protein, GST-Tagged | Wheat Germ | GST |
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| Human | ACP2-9307H | Recombinant Human ACP2, His-tagged | E.coli | His | 37-383a.a. | |
| Human | ACP2-9082HCL | Recombinant Human ACP2 293 Cell Lysate | HEK293 | N/A |
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| Human | ACP2-46H | Recombinant Human ACP2 Protein, His-tagged | E.coli | N-His | Tyr40-Ala250 |
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| Human | ACP2-801HF | Recombinant Full Length Human ACP2 Protein, GST-tagged | In Vitro Cell Free System | GST | 423 amino acids |
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| Human | ACP2-2666H | Recombinant Human ACP2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Mouse | Acp2-515M | Recombinant Mouse Acp2 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK |
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| Homo sapiens (Human) | RFL-26639HF | Recombinant Full Length Human Lysosomal Acid Phosphatase(Acp2) Protein, His-Tagged | E.coli expression system | His | Full Length (31-423) |
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| Mus musculus (Mouse) | RFL-2142MF | Recombinant Full Length Mouse Lysosomal Acid Phosphatase(Acp2) Protein, His-Tagged | E.coli expression system | His | Full Length (31-423) |
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| Rattus norvegicus (Rat) | RFL-3666RF | Recombinant Full Length Rat Lysosomal Acid Phosphatase(Acp2) Protein, His-Tagged | E.coli expression system | His | Full Length (31-423) |
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| Xenopus laevis (African clawed frog) | RFL-29323XF | Recombinant Full Length Xenopus Laevis Lysosomal Acid Phosphatase(Acp2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (33-432) |
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| Zebrafish | ACP2-2124Z | Recombinant Zebrafish ACP2 | Mammalian Cell | His |
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| Chicken | ACP2-3192C | Recombinant Chicken ACP2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
ACP2 involved in several pathways and played different roles in them. We selected most pathways ACP2 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | ACP5B;ATP6V0B;ENTPD4;CTSM;SLC11A2;GNPTAB;AP4E1;MFSD8;GNSB |
ACP2 has several biochemical functions, for example, acid phosphatase activity, phosphoprotein phosphatase activity, phosphotyrosine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACP2 itself. We selected most functions ACP2 had, and list some proteins which have the same functions with ACP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| acid phosphatase activity | ACP5A;MINPP1A;PPIP5K2;MINPP1B;ACP2;PXYLP1;ACPT;MINPP1;ACPL2 |
| phosphoprotein phosphatase activity | PPP1CC;PPP1CAA;PTPRZ1;PPP2CA;TIMM50;PPM1BA;CTDNEP1;PTPN4A;CDC14A |
| phosphotyrosine binding | STAP1;SAMSN1;ACP2;CBLC;SHC1;ZAP70;LDLRAP1;CBL;PTPN3 |
ACP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACP2.
cona_canen; CBX1
- Q&As
- Reviews
Q&As (10)
Ask a question100 mM NaCL, 20 mM Hepes, 10% glycerol. pH value is at the discretion of the manufacturer.
The high expression of ACP2 in CRC patients was associated with increased sensitivity to 5-FU chemotherapy.
The membrane-bound form is converted to the soluble form by sequential proteolytic processing; First, the C-terminal cytoplasmic tail is removed; Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen.
An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype.
Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures.
Among patients who received chemotherapy, those with an high expression of ACP2 showed better survival in both stage II and III colorectal cancer than those with low ACP2 expression.
D-Phenylalanine - Approved, Experimental, Investigational. D-Tyrosine - Approved, Experimental, Investigational.
ACP2 protein solution (1mg/ml) contains 20mM Tris-HCl (pH8.0) and 10% glycerol.
Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
They are TRHR, GMDS, SGCA, FPGS, and BAZ1B
Customer Reviews (5)
Write a reviewHighly recommended!
Great performance in ELISA.
Excellent, we will definitely go back to buy this again!
Fast delivery !
Satisfied with five starts!
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