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ACSM3

  • Official Full Name

    acyl-CoA synthetase medium-chain family member 3

  • Overview

    Acyl-coenzyme A synthetase ACSM3, mitochondrial is an enzyme that in humans is encoded by the ACSM3 gene.
  • Synonyms

    ACSM3; acyl-CoA synthetase medium-chain family member 3; SA (rat hypertension associated) homolog , SA hypertension associated homolog (rat) , SAH; acyl-coenzyme A synthetase ACSM3, mitochondrial; SA; Butyryl coenzyme A synthetase 3; mitochondrial; ACSM3_HUMAN; Acyl CoA synthetase medium chain family member 3; Acyl-coenzyme A synthetase ACSM3; Butyrate CoA ligase 3; Butyrate--CoA ligase 3; Butyryl-coenzyme A synthetase 3; Middle chain acyl CoA synthetase 3; Middle-chain acyl-CoA synthetase 3; Protein SA homolog; SA (rat hypertension associated) homolog; SA hypertension associated homolog; SA, rat, homolog of; SAH; OTTHUMP00000162290; SA hypertension-associated homolog; SA (rat hypertension-associated) homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACSM3-206H Recombinant Human ACSM3 Protein, GST-tagged Wheat Germ GST
Human ACSM3-9070HCL Recombinant Human ACSM3 293 Cell Lysate HEK293 N/A
Mouse ACSM3-1232M Recombinant Mouse ACSM3 Protein Mammalian Cell His
Mouse Acsm3-63M Recombinant Mouse Acsm3 Protein, His-tagged E.coli N-His Ala346-Thr580
Mouse ACSM3-276M Recombinant Mouse ACSM3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ACSM3-276M-B Recombinant Mouse ACSM3 Protein Pre-coupled Magnetic Beads HEK293
Rat ACSM3-474R Recombinant Rat ACSM3 Protein Mammalian Cell His
Rat Acsm3-64R Recombinant Rat Acsm3 Protein, His-tagged E.coli N-His Ser319-Thr580
Rat ACSM3-130R-B Recombinant Rat ACSM3 Protein Pre-coupled Magnetic Beads HEK293
Rat ACSM3-130R Recombinant Rat ACSM3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ACSM3-6269Z Recombinant Zebrafish ACSM3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ACSM3 involved in several pathways and played different roles in them. We selected most pathways ACSM3 participated on our site, such as Butanoate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Butanoate metabolismOXCT1B;HADHAB;ACSM2B;ACSM4;ACSM2;HADH;GAD1;OXCT2;L2HGDH
Metabolic pathwaysPLA2G2A;GCDHB;SARDH;CYP2C39;ADOB;AADAT;LASS2;WBSCR17;PFAS

ACSM3 has several biochemical functions, for example, ATP binding, butyrate-CoA ligase activity, fatty acid ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSM3 itself. We selected most functions ACSM3 had, and list some proteins which have the same functions with ACSM3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTRIB3;ITM2C;MASTL;DARS;IGF1RA;SYN2;ABL2;CHORDC1;HSP90AA1
butyrate-CoA ligase activityACSM5;ACSM1;AACS;ACSM3;ACSM4;ACSM2;ACSM2B;PPP1CA;Acsm2a
fatty acid ligase activityACSM3;ACSM1
metal ion bindingNEK2;NUDT14;ITGB1;ZMYND17;FTR43;ZNF474;ZNF718;DNAJA2L;PLEKHF1
molecular_functionHOXC12;STXBP1A;CCDC106B;TTC18;VWA5B1;PRL8A9;FNDC5;PRL8A8;PBLD1

ACSM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSM3.

VCAM1

  • Q&As
  • Reviews

Q&As (10)

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What is the potential of ACSM3 as a therapeutic target for metabolic disorders and cancer, and what challenges remain in developing effective ACSM3 inhibitors and activators? 10/09/2022

ACSM3 is a potential therapeutic target for metabolic disorders and cancer, but challenges remain in developing effective ACSM3 inhibitors and activators. These include issues with specificity, toxicity, and off-target effects, as well as the need for better understanding of ACSM3 function in different tissues and disease contexts.

How is ACSM3 expression regulated in different tissues, and what factors control its activity? 09/14/2021

ACSM3 expression is regulated by a variety of factors, including dietary and hormonal cues, transcriptional and epigenetic regulation, and post-transcriptional modifications such as phosphorylation and ubiquitination.

What is the effect of ACSM3-mediated acylation on protein function and stability, and how does this contribute to cellular signaling and regulation? 01/22/2021

ACSM3-mediated acylation can affect protein function and stability, as well as subcellular localization and interaction with other proteins.

How does ACSM3 interact with other lipid metabolism-related enzymes and transporters, such as fatty acid-binding protein (FABP) and carnitine palmitoyltransferase 1 (CPT1)? 02/11/2020

ACSM3 interacts with fatty acid-binding protein (FABP) and carnitine palmitoyltransferase 1 (CPT1), both of which are involved in the transport and utilization of fatty acids in cells.

How does ACSM3 interact with other proteins involved in lipid metabolism and transport, such as ATP-binding cassette transporter A1 (ABCA1) and sterol regulatory element-binding protein 1 (SREBP-1)? 01/19/2020

ACSM3 interacts with ATP-binding cassette transporter A1 (ABCA1) and sterol regulatory element-binding protein 1 (SREBP-1), both of which are involved in lipid metabolism and transport.

What is the role of ACSM3 in fatty acid metabolism, and how does it contribute to energy homeostasis in cells? 01/15/2020

ACSM3 plays a role in the transport and utilization of long-chain fatty acids in mitochondria and peroxisomes, which contributes to energy production and lipid homeostasis. It is also involved in regulating lipid droplet dynamics and the turnover of stored lipids in adipocytes and other cells.

What is the effect of ACSM3 deficiency or overexpression on energy metabolism, lipid accumulation, and insulin sensitivity in different tissues? 06/29/2019

ACSM3 deficiency or overexpression can lead to changes in energy metabolism, lipid accumulation, and insulin sensitivity in different tissues, which can contribute to metabolic disorders such as obesity and diabetes.

How does ACSM3 contribute to the regulation of inflammatory responses in metabolic and immune-related pathways? 05/28/2019

ACSM3 is implicated in the regulation of inflammatory responses in metabolic and immune-related pathways, particularly in the context of obesity and insulin resistance. It has been shown to modulate the activation of toll-like receptor 4 (TLR4) and the NLRP3 inflammasome in macrophages and other immune cells.

What is the effect of ACSM3 inhibition on cellular proliferation and apoptosis in cancer cells? 07/21/2018

ACSM3 inhibition has been shown to induce apoptosis and inhibit proliferation in cancer cells, suggesting a potential therapeutic target for cancer treatment.

What is the effect of genetic polymorphisms in ACSM3 on its expression and activity, and how do these variations contribute to disease susceptibility? 02/20/2018

Genetic polymorphisms in ACSM3 have been associated with altered expression and activity of the protein, as well as with increased risk of metabolic disorders such as obesity and type 2 diabetes.

Customer Reviews (5)

Write a review
Reviews
04/24/2022

    Its reliability allows us to generate robust data and draw meaningful conclusions in our experiments.

    03/10/2021

      Working with this protein is a breeze! It's like having a friendly assistant in the lab, always ready to lend a helping hand.

      09/23/2020

        Its high purity, stability, and functionality have surpassed our expectations, enabling precise and rigorous experimentation.

        01/14/2020

          Excellent customer service combined with top-notch quality. Worth every penny

          02/22/2018

            The manufacturer provides comprehensive after-sales service, and I am very satisfied with this.

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