ACSM3
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Official Full Name
acyl-CoA synthetase medium-chain family member 3
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Overview
Acyl-coenzyme A synthetase ACSM3, mitochondrial is an enzyme that in humans is encoded by the ACSM3 gene. -
Synonyms
ACSM3; acyl-CoA synthetase medium-chain family member 3; SA (rat hypertension associated) homolog , SA hypertension associated homolog (rat) , SAH; acyl-coenzyme A synthetase ACSM3, mitochondrial; SA; Butyryl coenzyme A synthetase 3; mitochondrial; ACSM3_HUMAN; Acyl CoA synthetase medium chain family member 3; Acyl-coenzyme A synthetase ACSM3; Butyrate CoA ligase 3; Butyrate--CoA ligase 3; Butyryl-coenzyme A synthetase 3; Middle chain acyl CoA synthetase 3; Middle-chain acyl-CoA synthetase 3; Protein SA homolog; SA (rat hypertension associated) homolog; SA hypertension associated homolog; SA, rat, homolog of; SAH; OTTHUMP00000162290; SA hypertension-associated homolog; SA (rat hypertension-associated) homolog;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ACSM3-206H | Recombinant Human ACSM3 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ACSM3-9070HCL | Recombinant Human ACSM3 293 Cell Lysate | HEK293 | N/A | ||
Mouse | ACSM3-1232M | Recombinant Mouse ACSM3 Protein | Mammalian Cell | His | ||
Mouse | Acsm3-63M | Recombinant Mouse Acsm3 Protein, His-tagged | E.coli | N-His | Ala346-Thr580 | |
Mouse | ACSM3-276M | Recombinant Mouse ACSM3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ACSM3-276M-B | Recombinant Mouse ACSM3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ACSM3-474R | Recombinant Rat ACSM3 Protein | Mammalian Cell | His | ||
Rat | Acsm3-64R | Recombinant Rat Acsm3 Protein, His-tagged | E.coli | N-His | Ser319-Thr580 | |
Rat | ACSM3-130R-B | Recombinant Rat ACSM3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ACSM3-130R | Recombinant Rat ACSM3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | ACSM3-6269Z | Recombinant Zebrafish ACSM3 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ACSM3 involved in several pathways and played different roles in them. We selected most pathways ACSM3 participated on our site, such as Butanoate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACSM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Butanoate metabolism | OXCT1B;HADHAB;ACSM2B;ACSM4;ACSM2;HADH;GAD1;OXCT2;L2HGDH |
Metabolic pathways | PLA2G2A;GCDHB;SARDH;CYP2C39;ADOB;AADAT;LASS2;WBSCR17;PFAS |
ACSM3 has several biochemical functions, for example, ATP binding, butyrate-CoA ligase activity, fatty acid ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACSM3 itself. We selected most functions ACSM3 had, and list some proteins which have the same functions with ACSM3. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | TRIB3;ITM2C;MASTL;DARS;IGF1RA;SYN2;ABL2;CHORDC1;HSP90AA1 |
butyrate-CoA ligase activity | ACSM5;ACSM1;AACS;ACSM3;ACSM4;ACSM2;ACSM2B;PPP1CA;Acsm2a |
fatty acid ligase activity | ACSM3;ACSM1 |
metal ion binding | NEK2;NUDT14;ITGB1;ZMYND17;FTR43;ZNF474;ZNF718;DNAJA2L;PLEKHF1 |
molecular_function | HOXC12;STXBP1A;CCDC106B;TTC18;VWA5B1;PRL8A9;FNDC5;PRL8A8;PBLD1 |
ACSM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACSM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACSM3.
VCAM1
- Q&As
- Reviews
Q&As (10)
Ask a questionACSM3 is a potential therapeutic target for metabolic disorders and cancer, but challenges remain in developing effective ACSM3 inhibitors and activators. These include issues with specificity, toxicity, and off-target effects, as well as the need for better understanding of ACSM3 function in different tissues and disease contexts.
ACSM3 expression is regulated by a variety of factors, including dietary and hormonal cues, transcriptional and epigenetic regulation, and post-transcriptional modifications such as phosphorylation and ubiquitination.
ACSM3-mediated acylation can affect protein function and stability, as well as subcellular localization and interaction with other proteins.
ACSM3 interacts with fatty acid-binding protein (FABP) and carnitine palmitoyltransferase 1 (CPT1), both of which are involved in the transport and utilization of fatty acids in cells.
ACSM3 interacts with ATP-binding cassette transporter A1 (ABCA1) and sterol regulatory element-binding protein 1 (SREBP-1), both of which are involved in lipid metabolism and transport.
ACSM3 plays a role in the transport and utilization of long-chain fatty acids in mitochondria and peroxisomes, which contributes to energy production and lipid homeostasis. It is also involved in regulating lipid droplet dynamics and the turnover of stored lipids in adipocytes and other cells.
ACSM3 deficiency or overexpression can lead to changes in energy metabolism, lipid accumulation, and insulin sensitivity in different tissues, which can contribute to metabolic disorders such as obesity and diabetes.
ACSM3 is implicated in the regulation of inflammatory responses in metabolic and immune-related pathways, particularly in the context of obesity and insulin resistance. It has been shown to modulate the activation of toll-like receptor 4 (TLR4) and the NLRP3 inflammasome in macrophages and other immune cells.
ACSM3 inhibition has been shown to induce apoptosis and inhibit proliferation in cancer cells, suggesting a potential therapeutic target for cancer treatment.
Genetic polymorphisms in ACSM3 have been associated with altered expression and activity of the protein, as well as with increased risk of metabolic disorders such as obesity and type 2 diabetes.
Customer Reviews (5)
Write a reviewIts reliability allows us to generate robust data and draw meaningful conclusions in our experiments.
Working with this protein is a breeze! It's like having a friendly assistant in the lab, always ready to lend a helping hand.
Its high purity, stability, and functionality have surpassed our expectations, enabling precise and rigorous experimentation.
Excellent customer service combined with top-notch quality. Worth every penny
The manufacturer provides comprehensive after-sales service, and I am very satisfied with this.
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