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Official Full Name actin, alpha 1, skeletal muscle
Background The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
Synonyms ACTA1; actin, alpha 1, skeletal muscle; ACTA; actin, alpha skeletal muscle; alpha-actin-1; alpha skeletal muscle actin; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; CFTD1; CFTDM
    • Species :
    • Bovine
    • Chicken
    • Human
    • Mouse
    • Porcine
    • Rabbit
    • Rat
    • Source :
    • E. coli
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • Pigeon Serum
    • Porcine skeletal muscle
    • Rabbit skeletal muscle
    • Rat Serum
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ACTA1 -125H Recombinant Human ACTA1 protein, GST-tagged Wheat Germ GST
    Human ACTA1-304H Recombinant Human ACTA1 Protein (3-377 aa), His-tagged E.coli His
    Human ACTA1-305H Recombinant Human ACTA1 protein, His-tagged E. coli His
    Human ACTA1-306H Recombinant Human ACTA1 protein, GST-tagged E.coli GST
    Human ACTA1-7HCL Recombinant Human ACTA1 lysate HEK293 N/A
    Mouse ACTA1-1238M Recombinant Mouse ACTA1 Protein Mammalian Cell His
    Mouse Acta1-158M Native Mouse skeletal muscle alpha Actin Pigeon Serum N/A
    Rat Acta1-3091R Recombinant Rat Acta1, His-tagged E.Coli or Yeast His
    Rat ACTA1-477R Recombinant Rat ACTA1 Protein Mammalian Cell His
    Bovine ACTA1-3090B Recombinant Bovine ACTA1, His-tagged E.Coli or Yeast His
    Rabbit ACTA1-157R Native Rabbit skeletal muscle alpha Actin Rat Serum N/A
    Chicken ACTA1-2743C Recombinant Chicken ACTA1 Mammalian Cell His
    Rabbit ACTA1-853R Native Rabbit ACTA1 Protein Rabbit skeletal muscle N/A
    Porcine ACTA1-854P Native Porcine ACTA1 Protein Porcine skeletal muscle N/A

    ACTA1 involved in several pathways and played different roles in them. We selected most pathways ACTA1 participated on our site, such as Caspase cascade in apoptosis, Hypothetical Network for Drug Addiction, Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Caspase cascade in apoptosis LMNB1; ACTA1; TOP1; CFL2; TFAP2A; CASP2; CRADD; GAS2; PARP1; NUMA1
    Hypothetical Network for Drug Addiction ZHX2; ACTA1; NISCH; TERF2IP; ACTA1B; GJB7; CX28.8
    Myometrial Relaxation and Contraction Pathways ATF5; IGFBP2; RGS14; RGS16; GABPB1; IGFBP4; GPR182; CRHR1; CORIN; RGS19
    RhoA signaling pathway DIAPH1; ACTA1; MKL1; CYR61
    Signaling events mediated by focal adhesion kinase BMX; ARHGEF28; ACTA1; ARHGAP26; KLF8
    Striated Muscle Contraction MYOM1; MYBPC1; TNNI2; CMLC1; TMOD1; DESMB; TNNI2B.2; DMD; MYBPC3; ACTA1

    ACTA1 has several biochemical functions, for example, ADP binding, ATP binding, myosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTA1 itself. We selected most functions ACTA1 had, and list some proteins which have the same functions with ACTA1. You can find most of the proteins on our site.

    Function Related Protein
    ADP binding PRPS1; ME1; MYO9B; MYO6; ACTA1; MYH10; GLUD2; ERN1; PKM; PRPS2
    ATP binding CCT6A; PI4KB; AARS; CHEK1; ORC4L; XRCC5; SMARCAD1; ROR2; DNAH11; Acsm2a
    myosin binding GIPC1; ARFGEF2; USH2A; VETZ; SMYD1B; DMD; CALD1; STX4A; NPHS1; ACTC1
    protein binding HFE; KCNA4; TNIP3; TIMM8A; APOBEC3C; SGOL1; CPNE7; CHST13; CHMP6; NBN
    structural constituent of cytoskeleton ARPC2; BFSP1; BICD1; TUBA4L; TUBA8L; SPTBN1; ACTL7A; TUBA4A; DMD; ARPC5

    ACTA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTA1.

    HTRA2; DNASE1; GC; GSN; ssh-2; Kcnma1; SSH3; SSH1; ZNF16; TNNI3K; TRIM63; RNF167; SMURF2; CD247; ARRB1; BTK; LRRK2; TRAF3IP1; LRCH3

    Schreckenbach, T; Schroder, JM; et al. Novel TPM3 mutation in a family with cap myopathy and review of the literature. NEUROMUSCULAR DISORDERS 24:117-124(2014).
    Nakagawa, Y; Inoue, H; et al. Molecular biological analysis of cardiac effect of high temperature in rats. LEGAL MEDICINE 14:63-68(2012).

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