|Official Full Name||actin, alpha 1, skeletal muscle|
|Background||The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.|
|Synonyms||ACTA1; actin, alpha 1, skeletal muscle; ACTA; actin, alpha skeletal muscle; alpha-actin-1; alpha skeletal muscle actin; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; CFTD1; CFTDM|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ACTA1 involved in several pathways and played different roles in them. We selected most pathways ACTA1 participated on our site, such as Caspase cascade in apoptosis, Hypothetical Network for Drug Addiction, Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Caspase cascade in apoptosis||LMNB1; ACTA1; TOP1; CFL2; TFAP2A; CASP2; CRADD; GAS2; PARP1; NUMA1|
|Hypothetical Network for Drug Addiction||ZHX2; ACTA1; NISCH; TERF2IP; ACTA1B; GJB7; CX28.8|
|Myometrial Relaxation and Contraction Pathways||ATF5; IGFBP2; RGS14; RGS16; GABPB1; IGFBP4; GPR182; CRHR1; CORIN; RGS19|
|RhoA signaling pathway||DIAPH1; ACTA1; MKL1; CYR61|
|Signaling events mediated by focal adhesion kinase||BMX; ARHGEF28; ACTA1; ARHGAP26; KLF8|
|Striated Muscle Contraction||MYOM1; MYBPC1; TNNI2; CMLC1; TMOD1; DESMB; TNNI2B.2; DMD; MYBPC3; ACTA1|
ACTA1 has several biochemical functions, for example, ADP binding, ATP binding, myosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTA1 itself. We selected most functions ACTA1 had, and list some proteins which have the same functions with ACTA1. You can find most of the proteins on our site.
|ADP binding||PRPS1; ME1; MYO9B; MYO6; ACTA1; MYH10; GLUD2; ERN1; PKM; PRPS2|
|ATP binding||CCT6A; PI4KB; AARS; CHEK1; ORC4L; XRCC5; SMARCAD1; ROR2; DNAH11; Acsm2a|
|myosin binding||GIPC1; ARFGEF2; USH2A; VETZ; SMYD1B; DMD; CALD1; STX4A; NPHS1; ACTC1|
|protein binding||HFE; KCNA4; TNIP3; TIMM8A; APOBEC3C; SGOL1; CPNE7; CHST13; CHMP6; NBN|
|structural constituent of cytoskeleton||ARPC2; BFSP1; BICD1; TUBA4L; TUBA8L; SPTBN1; ACTL7A; TUBA4A; DMD; ARPC5|
ACTA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTA1.
HTRA2; DNASE1; GC; GSN; ssh-2; Kcnma1; SSH3; SSH1; ZNF16; TNNI3K; TRIM63; RNF167; SMURF2; CD247; ARRB1; BTK; LRRK2; TRAF3IP1; LRCH3