ACTA1
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Official Full Name
actin, alpha 1, skeletal muscle
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Overview
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. -
Synonyms
ACTA1; actin, alpha 1, skeletal muscle; ACTA; actin, alpha skeletal muscle; alpha-actin-1; alpha skeletal muscle actin; ASMA; CFTD; MPFD; NEM1; NEM2; NEM3; CFTD1; CFTDM;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Porcine
- Rabbit
- Rat
- E. coli
- E.coli
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- Pigeon Serum
- Porcine skeletal muscle
- Rabbit skeletal muscle
- Rat Serum
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ACTA1 -125H | Recombinant Human ACTA1 protein, GST-tagged | Wheat Germ | GST | ||
Human | ACTA1-7HCL | Recombinant Human ACTA1 lysate | HEK293 | N/A | ||
Human | ACTA1-304H | Recombinant Human ACTA1 Protein (3-377 aa), His-tagged | E.coli | His | 3-377 aa | |
Human | ACTA1-306H | Recombinant Human ACTA1 protein, GST-tagged | E.coli | GST | 1-377 aa | |
Human | ACTA1-305H | Recombinant Human ACTA1 protein, His-tagged | E. coli | His | 1-377 aa | |
Mouse | ACTA1-1238M | Recombinant Mouse ACTA1 Protein | Mammalian Cell | His | ||
Mouse | Acta1-158M | Native Mouse skeletal muscle alpha Actin | Pigeon Serum | N/A | Full length native mouse skeletal muscle alpha Actin | |
Mouse | ACTA1-281M | Recombinant Mouse ACTA1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ACTA1-281M-B | Recombinant Mouse ACTA1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | Acta1-3091R | Recombinant Rat Acta1, His-tagged | E.Coli or Yeast | His | 377 | |
Rat | ACTA1-477R | Recombinant Rat ACTA1 Protein | Mammalian Cell | His | ||
Rat | ACTA1-133R-B | Recombinant Rat ACTA1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ACTA1-133R | Recombinant Rat ACTA1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rabbit | ACTA1-853R | Native Rabbit ACTA1 Protein | Rabbit skeletal muscle | N/A | 375 amino acids | |
Rabbit | ACTA1-157R | Native Rabbit skeletal muscle alpha Actin | Rat Serum | N/A | Full length native Rabbit skeletal muscle alpha Actin | |
Bovine | ACTA1-3090B | Recombinant Bovine ACTA1, His-tagged | E.Coli or Yeast | His | 377 | |
Porcine | ACTA1-854P | Native Porcine ACTA1 Protein | Porcine skeletal muscle | N/A | 375 amino acids | |
Chicken | ACTA1-2743C | Recombinant Chicken ACTA1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ACTA1 Related Articles
ACTA1 involved in several pathways and played different roles in them. We selected most pathways ACTA1 participated on our site, such as Caspase cascade in apoptosis, Hypothetical Network for Drug Addiction, Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Caspase cascade in apoptosis | TOP1;CFL2;DIABLO;CASP4;SATB1;CASP2;TFAP2A;DFFA;PARP1 |
Hypothetical Network for Drug Addiction | ACTA1;ZHX2;CX28.8;TERF2IP;ACTA1B;NISCH;GJB7 |
Myometrial Relaxation and Contraction Pathways | RGS7;GABPA;RXFP2;RGS20;CNN1;RGS5;RGS6;RAMP3;RGS4 |
RhoA signaling pathway | CYR61;ACTA1;MKL1;DIAPH1 |
Signaling events mediated by focal adhesion kinase | KLF8;BMX;ARHGAP26;ACTA1;ARHGEF28 |
Striated Muscle Contraction | SMYHC2;TCAP;TNNT3A;MYOM1;TMOD3;TNNI2A.3;DESMA;TMOD1;TNNI1B |
ACTA1 has several biochemical functions, for example, ADP binding, ATP binding, myosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTA1 itself. We selected most functions ACTA1 had, and list some proteins which have the same functions with ACTA1. You can find most of the proteins on our site.
Function | Related Protein |
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ADP binding | APAF1;MIEF1;P2RY1;MYO3A;MYO6;MYO9B;LONP1;GCLC;ACTA1 |
ATP binding | VARS;LIG3;NLRC4;ZAP70;GSK3AA;EK1;Acsm2a;RPS6KB1B;SMC4 |
myosin binding | CALD1;SLC6A4;SMYD1B;TRIM32;ACTA1;DMD;ARFGEF1;ACTC1;GIPC1 |
protein binding | FHIT;TFG;CHRNB2;FLVCR1;NCBP1;CCDC103;TDP1;TDRD7;SCRIB |
structural constituent of cytoskeleton | EPB41L3;KRT16;ACTL6B;SPRR2A1;TUBA7L;TUBGCP4;INA;TUBB2B;COX4I2 |
ACTA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTA1.
HTRA2; DNASE1; GC; GSN; ssh-2; Kcnma1; SSH3; SSH1; ZNF16; TNNI3K; TRIM63; RNF167; SMURF2; CD247; ARRB1; BTK; LRRK2; TRAF3IP1; LRCH3
- Q&As
- Reviews
Q&As (20)
Ask a questionThe Tg(ACTA1)(D286G) mice exhibited decreased activity levels, weaker skeletal muscles, and pathological lesions similar to those observed in human patients. However, unlike the patients, the mice had a normal lifespan.
The ACTA1 protein, also known as skeletal muscle α-actin, plays a crucial role in muscle contraction and the maintenance of muscle structure. It is a key component of the sarcomeres, the structural units of muscle fibers.
The presence of ringbinden fibers in the mouse models suggests that patients with ringbinden fibers of unknown genetic origin should be considered for ACTA1 mutation screening, indicating a possible link between these features and ACTA1 mutations.
ACTA1 is inhibited by PAX3-FOXO1 both at the transcriptional level and the protein level. This inhibition occurs through the RhoA-MKL1-SRF signaling pathway.
Researchers employ various techniques to study the ACTA1 protein, such as immunohistochemistry, immunoblotting, and mass spectrometry. These methods help identify the presence, abundance, and localization of ACTA1 in muscle tissues or cells.
Mutations in the ACTA1 gene account for a significant proportion of NM cases. Most of these mutations are missense mutations, which cause autosomal dominant NM by producing an abnormal protein. However, about 10% of ACTA1 gene mutations are associated with autosomal recessive NM, resulting in loss of protein function.
Yes, the ACTA1 protein interacts with other proteins involved in muscle function and structure. For example, it forms complexes with other actin-binding proteins, such as myosin and tropomyosin, to regulate muscle contraction.
Mutations in the skeletal muscle α-actin gene (ACTA1) cause various congenital myopathies, resulting in severe skeletal muscle weakness in most patients.
The majority of ACTA1 gene mutations cause autosomal dominant NM, meaning a single abnormal copy of the gene is sufficient to cause the disorder. In contrast, approximately 10% of ACTA1 gene mutations lead to autosomal recessive NM, requiring two copies of the mutated gene (one from each parent) to manifest the disorder.
The RhoA-MKL1-SRF signaling pathway is involved in mediating the inhibition of ACTA1 by PAX3-FOXO1. It is a signaling cascade that transmits the inhibitory signals from PAX3-FOXO1 to downregulate the expression of ACTA1.
The expression and regulation of the ACTA1 protein in skeletal muscle are tightly controlled by various molecular mechanisms, including transcriptional and post-transcriptional processes. These mechanisms ensure proper levels of ACTA1 for muscle function.
Mass spectrometry analysis revealed that the skeletal muscles of Tg(ACTA1)(D286G) mice contained approximately 25% of the ACTA1(D286G) protein.
CTA1 mutations can disrupt the normal organization of muscle fibers and sarcomeres, leading to structural abnormalities. These abnormalities can include the presence of nemaline bodies, actin accumulations, and widespread sarcomeric disarray.
Mutations in the ACTA1 gene can lead to various congenital myopathies, which are muscle disorders present from birth or early infancy. These mutations can disrupt the normal function and structure of skeletal muscles.
ACTA1 mutations can result in severe skeletal muscle weakness, leading to difficulties in movement and muscle function. In some cases, the severity of the mutations can be life-threatening, causing reduced lifespan and early mortality, as seen in certain dominant ACTA1 mutations.
Yes, there are various types of ACTA1 mutations identified in patients with congenital myopathies. These mutations can have different effects on the structure and function of the ACTA1 protein, leading to a spectrum of clinical presentations and disease severity.
Studies have suggested that altering the ratio of mutant ACTA1 protein to wild-type actin protein in patient muscles may hold promise as a potential therapy for patients with dominant ACTA1 disease
The ACTA1 protein is primarily found in skeletal muscle, which is responsible for voluntary muscle movement in the body.
The inhibition of ACTA1 by PAX3-FOXO1 is believed to play a role in the tumorigenesis and development of alveolar rhabdomyosarcoma (ARMS). It suggests that this regulatory mechanism contributes to the disease progression.
Altering the ratio of mutant ACTA1 protein to wild-type actin in patient muscle may be a potential therapy for patients with dominant ACTA1 disease.
Customer Reviews (5)
Write a reviewI found the protein product to be highly stable, retaining its functionality even after months of storage, which was crucial for my long-term experiments
The protein product's reliable performance and consistent quality reassured me that it would not introduce any confounding factors or jeopardize the integrity of my experiments.
I found the protein product to be compatible with various downstream applications, such as Western blotting and ELISA, broadening its utility in my researc
I appreciated the convenient packaging of the protein product, with individual aliquots that reduced the need for repeated thawing and freezing.
I appreciated the protein product's consistent performance at the specified concentrations, enabling me to achieve accurate dosing in my experiments
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