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ADAMTSL1

  • Official Full Name

    ADAMTS-like 1

  • Overview

    This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins.
  • Synonyms

    ADAMTSL1; ADAMTS-like 1; C9orf94, chromosome 9 open reading frame 94; ADAMTS-like protein 1; ADAMTSR1; FLJ35283; punctin; ADAM TS related protein 1; ADAM-TS related protein 1; ADAMTS like 1; ADAMTSR 1; C9orf94; Chromosome 9 open reading frame 94; MGC40193; Punctin 1; Thrombospondin; punctin-1; OTTHUMP00000021085; OTTHUMP00000021086; OTTHUMP00000021088; OTTHUMP00000239538; ADAMTSL-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • HIS
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADAMTSL1-7361H Recombinant Human ADAMTSL1 protein, His-tagged Insect Cells His Met1-His439
Human ADAMTSL1-157H Recombinant Human ADAMTSL1 Protein, HIS-tagged E.coli HIS
Human ADAMTSL1-310H Recombinant Human ADAMTSL1 Protein, GST-tagged Wheat Germ GST
Human ADAMTSL1-311H Recombinant Human ADAMTSL1 Protein, GST-tagged Wheat Germ GST
Human ADAMTSL1-001HCL Recombinant Human ADAMTSL1 cell lysate Insect Cell N/A
Human ADAMTSL1-5240H Recombinant Human ADAMTSL1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ADAMTSL1-1146H Recombinant Human ADAMTSL1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ADAMTSL1-5313H Recombinant Human ADAMTSL1 Protein (Met1-Lys422), C-His tagged Mammalian cells C-His Met1-Lys422
Human ADAMTSL1-5312H Recombinant Human ADAMTSL1 Protein (Met1-Lys439), C-His tagged Mammalian cells C-His Met1-Lys439
Human ADAMTSL1-919HF Recombinant Full Length Human ADAMTSL1 Protein, GST-tagged In Vitro Cell Free System GST 439 amino acids
Mouse Adamtsl1-1532M Recombinant Mouse Adamtsl1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADAMTSL1 Related Research Area

ADAMTSL1 involved in several pathways and played different roles in them. We selected most pathways ADAMTSL1 participated on our site, such as Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTSL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolism of proteinsIGFBP6;WDR85;MUC1;ADAMTS1;TUBA1B;TRAPPC9;MBOAT4;TBCE;FKBP9
O-glycosylation of TSR domain-containing proteinsC8orf84;ADAMTS10;B3GALTL;THSD7A;ADAMTS8;ADAMTS18;ADAMTSL5;SPON1B;SPON1
O-linked glycosylationTHSD1;B3GNT6;MUC4;ST6GALNAC2;MUC21;KCNA6;B3GNT2A;ADAMTS10;GALNT6
Post-translational protein modificationMUC12;CBX8;SPON2;PHC3;ARSF;NAPAB;KCNA6;ADAMTS13;ALG14

ADAMTSL1 has several biochemical functions, for example, metallopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTSL1 itself. We selected most functions ADAMTSL1 had, and list some proteins which have the same functions with ADAMTSL1. You can find most of the proteins on our site.

Function Related Protein
metallopeptidase activityCLCA4;COPS5;ADAM17A;ADAMTS9;ADAM30;CNDP2;HE1B;STAMBPL1;ADAM12
zinc ion bindingCPA4;TRAF7;ZDHHC6;RCHY1;CHD4A;FHL1A;RNF130;TRIML1;RNF112

ADAMTSL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTSL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTSL1.

  • Q&As
  • Reviews

Q&As (13)

Ask a question
How is ADAMTSL1 protein studied in the laboratory? 12/26/2022

ADAMTSL1 protein can be studied using a range of biochemical techniques including immunoblotting and immunohistochemistry. Animal models of ADAMTSL1-related disorders can also be used to study the molecular mechanisms underlying these diseases and to test potential therapeutic strategies.

What is the potential for ADAMTSL1 protein as a drug target? 09/25/2022

ADAMTSL1 protein may be a potential drug target for therapies aimed at treating disorders associated with abnormal extracellular matrix composition, such as Ehlers-Danlos syndrome. Targeting this protein may help normalize the extracellular matrix and improve symptoms associated with these disorders.

How can ADAMTSL1 protein be used as a biomarker for EDS? 11/21/2021

ADAMTSL1 protein levels in the blood or other bodily fluids may serve as a biomarker for EDS. Decreased levels of ADAMTSL1 protein are associated with certain types of EDS, such as the dermatosparaxis type. However, more research is needed to validate the specificity and sensitivity of ADAMTSL1 as a biomarker for EDS.

Are there any limitations in using ADAMTSL1 protein as a biomarker or drug target? 11/13/2021

One limitation in using ADAMTSL1 protein as a biomarker or drug target is the limited understanding of its exact role in different tissues and diseases. Other factors such as genetic variation in the ADAMTSL1 gene, environmental factors, and other interactions with cellular processes may also affect its applicability in different populations. Additionally, more research is needed to fully validate its potential as a biomarker and drug target.

What are some diseases associated with mutations in the ADAMTSL1 gene? 04/26/2020

Mutations in the ADAMTSL1 gene are associated with several connective tissue disorders, including dermatosparaxis-type Ehlers-Danlos syndrome, which is characterized by lax skin, joint hypermobility, and abnormal scarring. ADAMTSL1 mutations are also associated with Geleophysic dysplasia, a rare genetic disorder characterized by short stature, skeletal abnormalities, and facial dysmorphisms.

Are there any drugs or therapies targeting ADAMTSL1 protein currently in development? 01/25/2020

At this time, there are no drugs or therapies specifically targeting ADAMTSL1 protein in development for EDS or other related conditions. However, research into potential therapeutic targets for EDS is ongoing, and future drugs or therapies may target ADAMTSL1 or related proteins.

What is the diagnostic value of ADAMTSL1 protein in connective tissue disorders? 02/13/2018

Reduced levels of ADAMTSL1 protein in the blood or tissues have been found in individuals with dermatosparaxis-type Ehlers-Danlos syndrome, suggesting that it may serve as a diagnostic biomarker. However, further studies are needed to validate its use for diagnostic purposes.

What are some potential therapeutic targets for ADAMTSL1-related disorders? 12/24/2017

Some potential therapeutic targets for ADAMTSL1-related disorders include the use of gene therapy to restore the production of functional ADAMTSL1 protein, the development of small molecule inhibitors or activators of ADAMTSL1 function, and the use of drugs that regulate collagen production or turnover.

Can ADAMTSL1 protein be used as a therapeutic target for EDS? 11/23/2017

ADAMTSL1 protein may be a potential therapeutic target for treating EDS. Targeting this protein could help normalize the ECM and improve tissue structure and function in individuals with EDS. However, more research is needed to determine whether this approach is clinically feasible and effective.

What other conditions or diseases may ADAMTSL1 protein be linked to? 10/05/2016

ADAMTSL1 protein has been implicated in several other diseases, including Marfan syndrome, aortic aneurysms, and hypertension. However, the exact role of ADAMTSL1 in these conditions is less well understood and requires further investigation.

What are the potential applications of ADAMTSL1 protein? 06/26/2016

ADAMTSL1 protein has potential applications in research and clinical settings. It may be used as a biomarker to identify connective tissue disorders such as Ehlers-Danlos syndrome. ADAMTSL1 protein may also be a potential therapeutic target for treating disorders associated with abnormal extracellular matrix composition.

How can ADAMTSL1 protein be studied in the lab? 04/20/2016

ADAMTSL1 protein can be studied using a variety of methods, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assays (ELISAs). Animal and cellular models of EDS may also be used to study ADAMTSL1 function and potential therapeutic targets.

How can ADAMTSL1 protein be used as a biomarker? 01/10/2015

A decrease in ADAMTSL1 protein levels may be indicative of connective tissue disorders such as Ehlers-Danlos syndrome. Therefore, measuring ADAMTSL1 protein levels in serum or other bodily fluids may be a useful diagnostic tool for these disorders.

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