ADAMTSL5
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Official Full Name
ADAMTS-like 5
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Synonyms
ADAMTSL5;ADAMTS-like 5;27912;ENSG00000185761;THSD6;19p13.3;ADAMTS-like protein 5;ADAMTS-like protein 5;ADAMTSL-5;thrombospondin, type I, domain containing 6;thrombospondin type-1 domain-containing protein 6;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ADAMTSL5-1271H | Recombinant Human ADAMTSL5 | Mammalian Cell | His | ||
Human | ADAMTSL5-313H | Recombinant Human ADAMTSL5 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ADAMTSL5-8HCL | Recombinant Human ADAMTSL5 lysate | HEK293 | N/A | ||
Human | ADAMTSL5-920HF | Recombinant Full Length Human ADAMTSL5 Protein, GST-tagged | In Vitro Cell Free System | GST | 471 amino acids | |
Human | ADAMTSL5-1151H | Recombinant Human ADAMTSL5 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | ADAMTSL5-996H | Recombinant Human ADAMTSL5 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | ADAMTSL5-2427H | Recombinant Human ADAMTSL5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | ADAMTSL5-2427H-B | Recombinant Human ADAMTSL5 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Adamtsl5-1533M | Recombinant Mouse Adamtsl5 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
- Involved Pathway
- Protein Function
- Interacting Protein
ADAMTSL5 involved in several pathways and played different roles in them. We selected most pathways ADAMTSL5 participated on our site, such as Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTSL5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Metabolism of proteins | SAMM50;ST6GAL2B;CPE;EXOC1;CCDC59;SPON2;TRAPPC3;EEF1B2;ADAMTS4 |
O-glycosylation of TSR domain-containing proteins | SPON1;ADAMTS10;ADAMTS1;ADAMTSL4;THSD7A;ADAMTS3;SPON1B;SPON2;SPON1A |
O-linked glycosylation | ADAMTS15;GALNT6;GALNTL2;GALNTL5;THSD7A;A4GNT;KCNA6;B3GALTL;B3GNT2A |
Post-translational protein modification | BET1;SUMF2;SMC5;MAN1A2;NSMCE4A;MUC1;MAGT1;ARSF;B3GNT8 |
ADAMTSL5 has several biochemical functions, for example, heparin binding, metalloendopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTSL5 itself. We selected most functions ADAMTSL5 had, and list some proteins which have the same functions with ADAMTSL5. You can find most of the proteins on our site.
Function | Related Protein |
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heparin binding | SELP;FGF4;SOST;NAV2;ADAMTSL5;FGF2;VTN;GPNMB;GREM2 |
metalloendopeptidase activity | ADAMTS8;MEP1A.1;ADAM7;MMP15;MMP24;MEP1A.2;MMP17;MMP28;MMP1A |
protein binding | WDR24;MARK3;SLC3A1;VAMP3;FGFR1OP2;SHC3;CCDC86;ZNF177;SH2D1A |
zinc ion binding | TRIM35-29;ESR2;PIAS4B;TCF19;ZDHHC15A;RXRBA;ENPEP;RAD18;TRIM29 |
ADAMTSL5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTSL5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTSL5.
- Q&As
- Reviews
Q&As (14)
Ask a questionADAMTSL5 protein is being explored for its potential therapeutic applications in various fields, including regenerative medicine, tissue engineering, and osteoarthritis. Its ability to regulate extracellular matrix assembly and remodeling may make it a promising target for the development of therapies to treat conditions associated with tissue dysfunction or damage.
ADAMTSL5 protein levels can be measured in various ways, including Western blotting, ELISA, and immunohistochemistry. These methods typically involve using antibodies that specifically recognize ADAMTSL5 and can detect its expression or levels of accumulation in tissues or cells. However, the accuracy and specificity of these methods can vary depending on the tissue or sample being analyzed.
ADAMTSL5 protein may have potential as a biomaterial for use in tissue engineering applications. Its ability to regulate extracellular matrix assembly and remodeling could be leveraged to improve the structure and function of engineered tissues. Additionally, engineered tissues that incorporate ADAMTSL5 protein may be better able to integrate with host tissues, which could enhance their long-term viability and functional outcomes.
Currently, there are no clinical trials investigating the therapeutic potential of ADAMTSL5 protein. However, preclinical studies are ongoing to evaluate its safety and efficacy in various applications, including regenerative medicine and tissue engineering.
One of the main challenges in developing ADAMTSL5-based therapies is the difficulty of delivering the protein to specific tissues or organs. Because ADAMTSL5 is primarily produced by cells within these tissues, it may be difficult to target it specifically to the affected areas. In addition, the complexity of the extracellular matrix, and the interactions between ADAMTSL5 and other matrix proteins, may make it difficult to design effective therapies that can restore or modify its function. Nevertheless, ongoing research into the function and regulation of ADAMTSL5 may provide new insights into its therapeutic potential.
Currently, ADAMTSL5 protein is not used as a therapy for any condition. However, it has shown potential as a therapeutic target in various conditions, including cardiovascular diseases, skeletal disorders, and cancer, and research is ongoing to determine its potential clinical applications.
As of now, there are no clinical trials testing the use of ADAMTSL5 protein as a therapy. However, preclinical studies are ongoing to determine its potential for use as a therapeutic target in various conditions.
ADAMTSL5 protein has been shown to be downregulated in various types of cancer, including breast, lung, and prostate cancer, and has been suggested to play a role in inhibiting tumor growth and metastasis. Therefore, targeting ADAMTSL5 protein could potentially be used as a therapeutic strategy in cancer treatment.
ADAMTSL5 protein is involved in the regulation of vascular smooth muscle cell function, and has been shown to play a role in the development of atherosclerosis and hypertension. Therefore, ADAMTSL5 protein could potentially be used in the treatment of cardiovascular diseases by regulating vascular smooth muscle cell function and preventing or slowing down disease progression.
ADAMTSL5 protein is involved in the formation and maintenance of the extracellular matrix in bone tissue and has been shown to play a role in regulating bone growth and development. Therefore, ADAMTSL5 protein could potentially be used in the treatment of skeletal disorders, such as osteoporosis or osteogenesis imperfecta by restoring normal extracellular matrix function and preventing or slowing down disease progression.
ADAMTSL5 protein may have potential as a therapeutic agent to promote wound healing. Some studies have shown that ADAMTSL5 is involved in regulating cell migration and proliferation, which are essential processes in wound healing. Additionally, ADAMTSL5 may play a role in angiogenesis, which could enhance the growth of new blood vessels and promote tissue repair.
There is some evidence to suggest that ADAMTSL5 protein may have potential as a therapeutic agent for the treatment of osteoarthritis. Several studies have shown that ADAMTSL5 expression is altered in osteoarthritic cartilage, and that it may play a role in regulating cartilage maintenance and repair. However, additional research is needed to evaluate the safety and efficacy of using ADAMTSL5 protein for this purpose.
ADAMTSL5 protein is primarily produced by mesenchymal cells, including chondrocytes, fibroblasts, and smooth muscle cells. It is also found in various tissues and organs, including cartilage, skin, and blood vessels.
Because ADAMTSL5 protein has not been approved for clinical use, the potential side effects or risks are not well understood. However, as with any therapeutic protein, there may be risks of adverse immune reactions, toxicity, or off-target effects. These risks will need to be carefully assessed in preclinical and clinical studies before any potential therapeutic use of ADAMTSL5 protein can be considered.
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