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Recombinant Human ADAMTSL5 Protein, GST-tagged

Cat.No. : ADAMTSL5-313H
Product Overview : Human ADAMTSL5 full-length ORF (BAD18703.1, 1 a.a. - 471 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : ADAMTSL5 (ADAMTS Like 5) is a Protein Coding gene. Among its related pathways are O-glycosylation of TSR domain-containing proteins and HIV Life Cycle. GO annotations related to this gene include heparin binding and metalloendopeptidase activity. An important paralog of this gene is ADAMTSL4.
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 78.4 kDa
AA Sequence : MDSAPLFPRPHLFQNLLLFLWALLN CGLGVSAQGPGEWTPWVSWTRCSSS CGRGVSVRSRRCLRLPGEEPCWGDS HEYRLCQLPDCPPGAVPFRDLQCAL YNGRPVLGTQKTYQWVPFHGAPNQC DLNCLAEGHAFYHSFGRVLDGTACS PGAQGVCVAGRCLSAGCDGLLGSGA LEDRCGRCGGADDSCLFVQRVFRDA GAFAGYWNVTLIPEGARHIRVEHRS RNHLALMGGDGRYVLNGHWVVSPPG TYEAAGTHVVYTRDTGPQETLQAAG PTSHDLLLQVLLQEPNPGIEFEFWL PRERYSPFQARVQALGWPLRQPQPR GVEPQPPAAPAVTPAQTPTLAPDPC PPCPDTRGRAHRLLHYCGSDFVFQA RVLGHHHQAQETRYEVRIQLVYKNR SPLRAREYVWAPGHCPCPMLAPHRD YLMAVQRLVSPDGTQDQLLLPHAGY ARPWSPAEDSRIRLTARRCPG
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ADAMTSL5 ADAMTS-like 5 [ Homo sapiens ]
Official Symbol : ADAMTSL5
Synonyms : THSD6
Gene ID : 339366
mRNA Refseq : NM_213604.2
Protein Refseq : NP_998769.2
UniProt ID : Q6ZMM2

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What potential therapeutic applications are being explored for ADAMTSL5 protein? 12/30/2022

ADAMTSL5 protein is being explored for its potential therapeutic applications in various fields, including regenerative medicine, tissue engineering, and osteoarthritis. Its ability to regulate extracellular matrix assembly and remodeling may make it a promising target for the development of therapies to treat conditions associated with tissue dysfunction or damage.

How is ADAMTSL5 protein detected and measured? 06/06/2021

ADAMTSL5 protein levels can be measured in various ways, including Western blotting, ELISA, and immunohistochemistry. These methods typically involve using antibodies that specifically recognize ADAMTSL5 and can detect its expression or levels of accumulation in tissues or cells. However, the accuracy and specificity of these methods can vary depending on the tissue or sample being analyzed.

How could ADAMTSL5 protein be used in tissue engineering? 03/30/2021

ADAMTSL5 protein may have potential as a biomaterial for use in tissue engineering applications. Its ability to regulate extracellular matrix assembly and remodeling could be leveraged to improve the structure and function of engineered tissues. Additionally, engineered tissues that incorporate ADAMTSL5 protein may be better able to integrate with host tissues, which could enhance their long-term viability and functional outcomes.

Are there any clinical trials currently investigating the therapeutic potential of ADAMTSL5 protein? 01/03/2021

Currently, there are no clinical trials investigating the therapeutic potential of ADAMTSL5 protein. However, preclinical studies are ongoing to evaluate its safety and efficacy in various applications, including regenerative medicine and tissue engineering.

What are the current challenges in developing ADAMTSL5-based therapies? 09/03/2020

One of the main challenges in developing ADAMTSL5-based therapies is the difficulty of delivering the protein to specific tissues or organs. Because ADAMTSL5 is primarily produced by cells within these tissues, it may be difficult to target it specifically to the affected areas. In addition, the complexity of the extracellular matrix, and the interactions between ADAMTSL5 and other matrix proteins, may make it difficult to design effective therapies that can restore or modify its function. Nevertheless, ongoing research into the function and regulation of ADAMTSL5 may provide new insights into its therapeutic potential.

Is ADAMTSL5 protein currently used as a therapy for any condition? 01/24/2020

Currently, ADAMTSL5 protein is not used as a therapy for any condition. However, it has shown potential as a therapeutic target in various conditions, including cardiovascular diseases, skeletal disorders, and cancer, and research is ongoing to determine its potential clinical applications.

Are there any current clinical trials testing the use of ADAMTSL5 protein as a therapy? 09/06/2019

As of now, there are no clinical trials testing the use of ADAMTSL5 protein as a therapy. However, preclinical studies are ongoing to determine its potential for use as a therapeutic target in various conditions.

Could ADAMTSL5 protein be used to treat cancer? 04/03/2019

ADAMTSL5 protein has been shown to be downregulated in various types of cancer, including breast, lung, and prostate cancer, and has been suggested to play a role in inhibiting tumor growth and metastasis. Therefore, targeting ADAMTSL5 protein could potentially be used as a therapeutic strategy in cancer treatment.

How could ADAMTSL5 protein be used in the treatment of cardiovascular diseases? 01/27/2019

ADAMTSL5 protein is involved in the regulation of vascular smooth muscle cell function, and has been shown to play a role in the development of atherosclerosis and hypertension. Therefore, ADAMTSL5 protein could potentially be used in the treatment of cardiovascular diseases by regulating vascular smooth muscle cell function and preventing or slowing down disease progression.

Can ADAMTSL5 protein be used to treat skeletal disorders? 03/14/2018

ADAMTSL5 protein is involved in the formation and maintenance of the extracellular matrix in bone tissue and has been shown to play a role in regulating bone growth and development. Therefore, ADAMTSL5 protein could potentially be used in the treatment of skeletal disorders, such as osteoporosis or osteogenesis imperfecta by restoring normal extracellular matrix function and preventing or slowing down disease progression.

Could ADAMTSL5 protein be used to promote wound healing? 07/21/2017

ADAMTSL5 protein may have potential as a therapeutic agent to promote wound healing. Some studies have shown that ADAMTSL5 is involved in regulating cell migration and proliferation, which are essential processes in wound healing. Additionally, ADAMTSL5 may play a role in angiogenesis, which could enhance the growth of new blood vessels and promote tissue repair.

Can ADAMTSL5 protein be used to treat osteoarthritis? 02/17/2017

There is some evidence to suggest that ADAMTSL5 protein may have potential as a therapeutic agent for the treatment of osteoarthritis. Several studies have shown that ADAMTSL5 expression is altered in osteoarthritic cartilage, and that it may play a role in regulating cartilage maintenance and repair. However, additional research is needed to evaluate the safety and efficacy of using ADAMTSL5 protein for this purpose.

What are the sources of ADAMTSL5 protein? 06/27/2015

ADAMTSL5 protein is primarily produced by mesenchymal cells, including chondrocytes, fibroblasts, and smooth muscle cells. It is also found in various tissues and organs, including cartilage, skin, and blood vessels.

What are the potential side effects or risks associated with the use of ADAMTSL5 protein in therapy? 01/09/2015

Because ADAMTSL5 protein has not been approved for clinical use, the potential side effects or risks are not well understood. However, as with any therapeutic protein, there may be risks of adverse immune reactions, toxicity, or off-target effects. These risks will need to be carefully assessed in preclinical and clinical studies before any potential therapeutic use of ADAMTSL5 protein can be considered.

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