ADD1
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Official Full Name
adducin 1 (alpha)
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Overview
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. -
Synonyms
ADD1; adducin 1 (alpha); alpha-adducin; erythrocyte adducin alpha subunit; ADDA; MGC3339; MGC44427;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
ADD1 involved in several pathways and played different roles in them. We selected most pathways ADD1 participated on our site, such as Apoptosis, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis | CFLARA;PRKAR1A;CYCSB;RELA;PRKAR2AA;CAPN2B;PRKACA;TNFSF10;DSP |
| Apoptotic cleavage of cellular proteins | CTNNB1;CTNNB2;DBNLA;SATB1;DSP;STK26;DBNLB;DSG3;DSG2 |
| Apoptotic execution phase | HMGB2;HMGB2A;CLSPN;STK24;VIML;DSG3;LMNB1;PTBP3;HIST1H1E |
| Caspase-mediated cleavage of cytoskeletal proteins | VIML;GAS2;DBNL;ADD1;PLEC;CASP6L2;SPNA2;DBNLB;PLECA |
| IRE1alpha activates chaperones | HYOU1;KDELR3;FKBP14;SERP1;ASNA1;WIPI1;TPP1;SEC63;DDX11 |
| Metabolism of proteins | EIF5A;TRAPPC6BL;ADAMTSL5;ALG2;CGB5;SEMG1;IGFBP5B;ANKRD28;TIMM17B |
| Miscellaneous transport and binding events | EPB49;ADD2;ANKH;ANKHA;ADD3A;MMGT1;ANKHB;ADD3;PIP |
| Programmed Cell Death | GAS2;STK26;BAXB;DNM1L;MLKL;DSP;GZME;DBNLB;PLECA |
ADD1 has several biochemical functions, for example, actin binding, actin filament binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADD1 itself. We selected most functions ADD1 had, and list some proteins which have the same functions with ADD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | ACTR2B;ABLIM1A;MICAL1;ABLIM2;MSNA;PHACTR1;LSP1;PHACTR3B;MYH8 |
| actin filament binding | ANXA8;FSCN1;AJUBA;TRIOBPB;CAPZB;FSCN2;SYNE1;TAGLN3B;LCP1 |
| calmodulin binding | SPTAN1;SCN5A;MYO6;CNN2;MYO5C;ADD1;STRN;UBR4;SLC8A2 |
| poly(A) RNA binding | MOV10;ALDOA;EBNA1BP2;RPL21;RPL5;ZCRB1;RBMS1;PUM2;HIST1H4C |
| protein binding | AMPD2;PAGE2;GLYR1;C11orf49;CSNK1E;RPS27L;SEMA3E;EVI5;CA4 |
| protein heterodimerization activity | NEFL;SOX4;MAFG;HIST1H2BN;HNF1A;HIST2H2AC;DR1;SOX15;PVALB |
| protein homodimerization activity | LSM1;FGFR1OP2;TYW5;ABCD2;WHRN;ACOT7;TRIM37;CADM2A;GOLGA5 |
| spectrin binding | DYNC1I1;CAMSAP1;USH1C;PDE6G;GNB1;CAMSAP1L1;EPB41;ADD2;ANK1 |
| structural molecule activity | CLDND;ANXA1;CKI;KRT4;ISCA2;NEFMA;KRT85;CLDN1;KRT76 |
| transcription factor binding | PPRC1;NBN;GATA3;HES3;ARHGEF2;SOX10;NFIA;CXXC5;HIF1A |
ADD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADD1.
RFX1; saicar; PKM; TK1; CSNK2B; ppdK; icmF1; mfd; q8czf9_yerpe; chbG; MAP1LC3B; GEMIN7; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; DST; ssdna_dtdg; TPM3
- Q&As
- Reviews
Q&As (10)
Ask a questionSpecific antibodies or probes can be developed to visualize the localization of ADD1 in live cells or tissues.
Altering the expression level or activity of ADD1 can affect cellular processes like cell proliferation, differentiation, or apoptosis.
The expression of ADD1 can change under different physiological or pathological conditions.
ADD1 exhibits subcellular localization in various cellular compartments, such as the nucleus or cytoplasm.
ADD1 interacts with specific binding proteins or partners in a context-dependent manner.
The tissue-specific expression pattern of ADD1 varies across organs and cell types.
ADD1 undergoes post-translational modifications, including phosphorylation and acetylation, which can impact its activity and stability.
There may exist small molecule inhibitors or activators that can modulate ADD1's function, with distinct mechanisms of action.
Specific domains or motifs within ADD1 are responsible for its functional activities.
ADD1 regulates downstream target genes or signaling pathways that contribute to its biological functions.
Customer Reviews (3)
Write a reviewHighly effective in detecting and quantifying the expression levels of fusion proteins in protein expression analysis.
Highly specific in detecting the target protein in tissue sections in immunohistochemistry experiments.
Demonstrates high selectivity and sensitivity in detecting protein-protein interactions in pull-down assays.
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