Recombinant Human ADD1 Protein, GST-tagged

• Cat.No.: ADD1-336H
• Product Overview: Human ADD1 full-length ORF ( AAH42998, 1 a.a. - 662 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 98.56 kDa
• AA Sequence: MNGDSRAAVVTSPPPTTAPHKERYF DRVDENNPEYLRERNMAPDLRQDFN MMEQKKRVSMILQSPAFCEELESMI QEQFKKGKNPTGLLALQQIADFMTT NVPNVYPAAPQGGMAALNMSLGMVT PVNDLRGSDSIAYDKGEKLLRCKLA AFYRLADLFGWSQLIYNHITTRVNS EQEHFLIVPFGLLYSEVTASSLVKI NLQGDIVDRGSTNLGVNQAGFTLHS AIYAARPDVKCVVHIHTPAGAAVSA MKCGLLPISPEALSLGEVAYHDYHG ILVDEEEKVLIQKNLGPKSKVLILR NHGLVSVGESVEEAFYYIHNLVVAC EIQVRTLASAGGPDNLVLLNPEKYK AKSRSPGSPVGEGTGSPPKWQIGEQ EFEALMRMLDNLGYRTGYPYRYPAL REKSKKYSDVEVPASVTGYSFASDG DSGTCSPLRHSFQKQQREKTRWLNS GRGDEASEEGQNGSSPKSKTKWTKE DGHRTSTSAVPNLFVPLNTNPKEVQ EMRNKIREQNLQDIKTAGPQSQVLC GVVMDRSLVQDAPLSDCTETIEGLE LTEQTFSPAKSLSFRKGELVTASKA IIEKEYQPHVIVSTTGPNPFTTLTD RELEEYRREVERKQKGSEENLDEAR EQKEKSPPDQPAVPHPPPSTPIKLE EGDGCAREYLLP
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ADD1 adducin 1 (alpha) [ Homo sapiens ]
• Official Symbol: ADD1
• Synonyms: ADD1; adducin 1 (alpha); alpha-adducin; erythrocyte adducin alpha subunit; ADDA; MGC3339; MGC44427
• Gene ID: 118
• mRNA Refseq: NM_001119
• Protein Refseq: NP_001110
• MIM: 102680
• UniProt ID: P35611