ADH1A
-
Official Full Name
alcohol dehydrogenase 1A (class I), alpha polypeptide
-
Overview
Human alcohol dehydrogenase (ADH) genes are grouped into five classes, with three distinct class I ADH genes (ADH1A, ADH1B and ADH1C) and ADH4, ADH5, ADH7 and ADH6 belonging to classes II, III, IV, and V, respectively. ADH is a zinc-containing, dimeric en -
Synonyms
ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide; ADH1; alcohol dehydrogenase 1A; ADH, alpha subunit; aldehyde reductase; alcohol dehydrogenase subunit alpha; alcohol dehydrogenase 1 (class I), alpha polypeptide;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
ADH1A involved in several pathways and played different roles in them. We selected most pathways ADH1A participated on our site, such as Abacavir metabolism, Abacavir transport and metabolism, Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Abacavir metabolism | ADH1A;ADH8B;ADH8A;ADAL |
| Abacavir transport and metabolism | ADH1A;ADH8B;ADH8A;ADAL |
| Biological oxidations | CYP2K6;AS3MT;CYP27B1;CYP27A1;ACY3.1;PRKRA;CYP1A2;CYP2S1;ACY3 |
| Chemical carcinogenesis | ALDH3A1;CYP3A5;UGT2B15;UGT2A2;CYP2C39;CBR1;PTGS2;CYP2C55;GSTA5 |
| Drug metabolism - cytochrome P450 | ADH1B;ADH1C;CYP2C8;CYP2A6;ADH5;CYP2C9;GSTK1;ADH7;ADH2-1 |
| Ethanol oxidation | ADH1B;ADH6;ADH8A;ADH4;ADH5;ADH1C;ADH1A;ADH8B;ADH7 |
| Fatty Acid Omega Oxidation | CYP2A6;ADH1C;CYP4A11;ADH6;ADH7;ADH1B;ADH4;CYP1A1;CYP2D6 |
| Fatty acid degradation | ACSL5;ADH4;CYP4A12A;ACADL;ACAA1;ALDH9A1A.1;ADH1A;ALDH3A2A;ECI2 |
ADH1A has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity, alcohol dehydrogenase activity, zinc-dependent, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH1A itself. We selected most functions ADH1A had, and list some proteins which have the same functions with ADH1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alcohol dehydrogenase (NAD) activity | DHRS9;ADH1;ADH7;ADH8B;ADH1A;ADH4;ADH8A;ADH5;ADH6 |
| alcohol dehydrogenase activity, zinc-dependent | ADH1A;ADH4;ADH1B;ADH7 |
| protein binding | CCNY;HPGDS;CORO1C;CRYBB1;SNAP25;GHITM;NIPBL;RAD21;GKAP1 |
| zinc ion binding | NR2F6A;PDZRN3;CA4A;MSRB2;RNF111;RFWD3;ZRANB1;DNAJC24;RNF145B |
ADH1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH1A.
CSNK2A2; HADH
- Q&As
- Reviews
Q&As (10)
Ask a questionThe expression of ADH1A is regulated by specific mechanisms, including transcriptional and post-transcriptional regulation, which can respond to alcohol exposure or metabolic factors such as hormonal signaling.
ADH1A requires specific cofactors or coenzymes, such as NAD+ or NADH, for its activity, serving as electron carriers and modulators of ADH1A function.
ADH1A plays a significant role in alcohol metabolism, showing specific catalytic efficiency and substrate specificity for the conversion of alcohol to acetaldehyde.
ADH1A deficiency or knockout in experimental models leads to altered alcohol metabolism and related phenotypes, such as decreased alcohol clearance and increased sensitivity to alcohol-induced effects.
ADH1A exhibits a tissue-specific expression pattern, with higher expression levels in certain organs such as the liver, and its distribution may differ from other ADH isoforms, reflecting functional specialization.
Genetic variations or polymorphisms in the ADH1A gene have been associated with differences in alcohol metabolism and susceptibility to alcohol-related disorders, highlighting the impact of genotype on phenotype.
Pharmacological agents or environmental factors can modulate ADH1A expression or activity, potentially influencing alcohol metabolism and providing avenues for therapeutic interventions or personalized medicine.
ADH1A has the capacity to metabolize other substrates beyond alcohol, suggesting its involvement in broader metabolic pathways and potential metabolic interactions.
ADH1A expression or activity may vary among different species or populations, influenced by genetic and environmental factors, contributing to inter-individual or inter-species differences in alcohol metabolism and tolerance.
The structural features of ADH1A, such as its active site and binding domains, are critical for its enzymatic activity and substrate recognition, enabling efficient alcohol oxidation.
Customer Reviews (2)
Write a reviewExhibits remarkable enzymatic activity under a wide range of pH conditions.
Provides reliable and consistent results in protein folding and unfolding studies.
Ask a Question for All ADH1A Products
Required fields are marked with *
My Review for All ADH1A Products
Required fields are marked with *
