ADH4
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Official Full Name
alcohol dehydrogenase 4 (class II), pi polypeptide -
Overview
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. -
Synonyms
ADH4;alcohol dehydrogenase 4 (class II), pi polypeptide;alcohol dehydrogenase 4;ADH 2;aldehyde reductase;alcohol dehydrogenase class II pi chain;ADH-2
Recombinant Proteins
- Human
- Mouse
- S.cerevisiae
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
ADH4 involved in several pathways and played different roles in them. We selected most pathways ADH4 participated on our site, such as Biological oxidations,Chemical carcinogenesis,Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biological oxidations | CYP27B1,CYP8B2,CYP2K17,SULT1ST6,SULT2ST2,UGT1B4,NCOA2,SLC35B3,UGT1B1,CYP2C9 |
| Glycolysis / Gluconeogenesis | ACSS2,ALDH3A2,GPI,pykF,LDHB,ALDOCB,ALDH2,ALDOA,MINPP1,G6PC2 |
| Ethanol oxidation | ADH8A,ADH6,ADH1C,ADH1B,ADH1A,ADH5,ADH7,ADH8B |
| Metabolic pathways | GMDS,B4GALT4,KHK,SGMS2,LPIN2,POLR2GL,NT5E,ENO1B,TPH1B,ASL2 |
| Chemical carcinogenesis | SULT1A2,AHA-1,CCBL1,UGT1A7C,ADH1B,GSTO1,NAT1,CYP2C37,GSTA5,ADH7 |
| Fatty acid degradation | ADH7,ADH5,ADH1B,CYP4A14,HADHB,ALDH9A1B,CPT2,ACSL3,GCDH,ACSL1B |
| Drug metabolism - cytochrome P450 | CYP2C8,ADH1B,ADH1C,CYP2C9,ADH6,CYP2E1,CYP2C19,CYP3A5,ADH7,ADH5 |
| Fatty Acid Omega Oxidation | CYP1A1,ADH1A,ADH1B,CYP4A11,ADH6,CYP2E1,ADH1C,CYP2D6,CYP2A6,ADH7 |
Protein Function
ADH4 has several biochemical functions, for example, NAD binding,NADPH:quinone reductase activity,alcohol dehydrogenase (NAD) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH4 itself. We selected most functions ADH4 had, and list some proteins which have the same functions with ADH4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | ADAMDEC1,MTA3,ZACN,TIMM13,NPLOC4,MT1F,SERPINB1A,RFPL4,TNP2,NR5A1A |
| NAD binding | AOX4,NDUFV1,IDH2,NNT,HIBADHA,HSD3B4,HADHA,GPD1,GRHPRA,GPD1B |
| retinol binding | C8G,RBP2,RBP4,ADH7,RBP7,RLBP1,RBP5,CRABP2,RBP3,RBP1 |
| alcohol dehydrogenase activity, zinc-dependent | ADH1B,ADH1A,ADH7 |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | Aldh1a7,ALDH3A2A,ALDH9A1B,ALDH2.2,ALDH9A1A.1,ALDH3A2B,ALDH9A1A.2,ALDH2.1 |
| NADPH:quinone reductase activity | CRYZ,TP53I3,CRYZL1 |
| alditol:NADP+ 1-oxidoreductase activity | AKR7A5,AKR7A2,Akr1b3,AKR1B8,AKR1C2,PRKRA,AKR1B1,AKR1B7,AKR1C21,AKR1C3 |
| alcohol dehydrogenase (NAD) activity | ADH6,ADH1,ADH1C,DHRS9,ADH7,ADH5,ADH8B,ADH1A,ADH8A |
| ethanol binding | PRKCE,ADH7,ADH1 |
Interacting Protein
ADH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH4.
RPL35
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