ADH4

  • Official Full Name

    alcohol dehydrogenase 4 (class II), pi polypeptide
  • Overview

    This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.
  • Synonyms

    ADH4;alcohol dehydrogenase 4 (class II), pi polypeptide;alcohol dehydrogenase 4;ADH 2;aldehyde reductase;alcohol dehydrogenase class II pi chain;ADH-2

Recombinant Proteins

  • Human
  • Mouse
  • S.cerevisiae
  • E.coli
  • Mammalian Cells
  • E.Coli/Yeast
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ADH4-3810H Recombinant Human ADH4 protein, His-tagged E.coli Human His 1-380 aa
ADH4-9419H Recombinant Human ADH4 protein, GST-tagged E.coli Human GST 1-380 aa
ADH4-1354M Recombinant Mouse ADH4 Protein Mammalian Cells Mouse His
ADH4-3252H Recombinant Human ADH4, His-tagged E.Coli/Yeast Human His 380
ADH4-347H Recombinant Human ADH4 Protein, GST-tagged Wheat Germ Human GST
ADH4-29HCL Recombinant Human ADH4 cell lysate Human Non
ADH4-0252H Recombinant Human ADH4 Protein (M1-F380), Tag Free E.coli Human Non M1-F380
ADH4-0253H Recombinant Human ADH4 Protein (M1-F380), GST tagged E.coli Human GST M1-F380
ADH4-1005H Recombinant Saccharomyces cerevisiae ADH4 Protein (S2-Y382), Tag Free E.coli S.cerevisiae Non S2-Y382
ADH4-12H Recombinant Human ADH4 Protein, N-GST and C-His tagged E.coli Human GST&His
ADH4-343M Recombinant Mouse ADH4 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ADH4-343M-B Recombinant Mouse ADH4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ADH4-926HF Recombinant Full Length Human ADH4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 380 amino acids
ADH7-22HFL Recombinant Full Length Human ADH7 Protein, C-Myc/DDK-tagged HEK293 Human DDK&Myc Full L.

    Involved Pathway

    ADH4 involved in several pathways and played different roles in them. We selected most pathways ADH4 participated on our site, such as Biological oxidations,Chemical carcinogenesis,Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycolysis / Gluconeogenesis PGAM2,LDHBB,ALDH2.1,G6PC,FBP1B,ALDOA,ALDH1A3,PGK1,AKR1A1B,LDHC
    Chemical carcinogenesis SULT1A3,CYP3A7,CYP1B1,CYP2B19,GSTT1,CYP2E1,CYP3A41B,MGST3,GSTM3,CYP3A25
    Ethanol oxidation ADH8A,ADH7,ADH1A,ADH6,ADH1C,ADH8B,ADH5,ADH1B
    Metabolic pathways COX7B,AGXT,ATP6V0A2,AOX3L1,CYP26A1,COQ2,COX17,SI,ADPGK,DHRS9
    Fatty Acid Omega Oxidation CYP4A11,CYP1A1,CYP2A6,ADH6,ADH1A,ADH1B,CYP2D6,ADH1C,CYP2E1,ADH7
    Drug metabolism - cytochrome P450 CYP2E1,CYP2C9,ADH2-2,CYP2C8,ADH7,ADH1C,GSTO2,CYP2B6,CYP3A5,ADH1B
    Fatty acid degradation GCDH,ALDH2.2,ADH2-1,ACADL,ACSL5,ACAT2,ACSL3A,ACAA1A,ACSL1,ALDH2
    Biological oxidations UGT1B2,ADH8B,CYP1A1,SLC35B2,CYP4F11,CYP7A1,CYP17A1,AADAC,CYP2C18,CYP24A1

    Protein Function

    ADH4 has several biochemical functions, for example, NAD binding,NADPH:quinone reductase activity,alcohol dehydrogenase (NAD) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH4 itself. We selected most functions ADH4 had, and list some proteins which have the same functions with ADH4. You can find most of the proteins on our site.

    Function Related Protein
    alcohol dehydrogenase activity, zinc-dependent ADH7,ADH1B,ADH1A
    ethanol binding ADH7,PRKCE,ADH1
    alcohol dehydrogenase (NAD) activity ADH6,ADH5,ADH1A,ADH8B,ADH8A,ADH7,ADH1,ADH1C,DHRS9
    NAD binding PARP1,GAPDHS,HSD17B10,UGDH,HSD11B2,HIBADHA,ME1,HIBADH,GRHPRB,CTBP1
    alditol:NADP+ 1-oxidoreductase activity AKR1A1,AKR1C2,AKR1C21,AKR1B7,AKR1B1,AKR7A5,AKR1C3,PRKRA,AKR1B8,Akr1b3
    NADPH:quinone reductase activity TP53I3,CRYZ,CRYZL1
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ALDH3A2B,ALDH9A1A.1,ALDH3A2A,ALDH2.1,Aldh1a7,ALDH9A1A.2,ALDH2.2,ALDH9A1B
    zinc ion binding ZNF330,DTX1,FHL3B,MANEA,RFPL3,SOD1,CPZ,NEURL1AA,NR4A2B,ZCCHC3
    retinol binding RBP1,RBP4,RBP5,CRABP2,ADH7,RBP2,C8G,RBP3,LRAT,RLBP1

    Interacting Protein

    ADH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH4.

    RPL35

    Resources

    References

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