ADH4
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Official Full Name
alcohol dehydrogenase 4 (class II), pi polypeptide
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Overview
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. -
Synonyms
ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide; alcohol dehydrogenase 4; ADH 2; aldehyde reductase; alcohol dehydrogenase class II pi chain; ADH-2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- S.cerevisiae
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Strep
- Myc
- DDK
- N/A
- N
- C
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
ADH4 involved in several pathways and played different roles in them. We selected most pathways ADH4 participated on our site, such as Biological oxidations, Chemical carcinogenesis, Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biological oxidations | PAOX;UGT1B1;UGT1B4;CYP19A1;AKR1A1;AHCY;CYP2K8;GLYATL2;GSTK1 |
| Chemical carcinogenesis | CYP3A25;CYP3A5;GSTA4;GSTT1;UGT2A2;UGT1A6B;CYP2B19;ALDH3B2;CHRNA7 |
| Drug metabolism - cytochrome P450 | GSTK1;GSTO2;CYP2B6;ADH1A;ADH4;ADH6;ADH5;ADH7;CYP2C9 |
| Ethanol oxidation | ADH6;ADH8A;ADH7;ADH1A;ADH1B;ADH4;ADH5;ADH8B;ADH1C |
| Fatty Acid Omega Oxidation | ADH4;ADH1A;ADH6;ADH7;CYP1A1;CYP2E1;ADH1B;CYP2D6;CYP2A6 |
| Fatty acid degradation | ALDH7A1;ACADSB;HADH;ADH2-1;ALDH2.2;ACAA2;ACSL4;ACSBG2;ACSL5 |
| Glycolysis / Gluconeogenesis | ALDH3B2;ALDOAA;ALDH7A1;ALDOB;PCK1;BPGM;LDHBA;LDHAL6B;ALDH9A1A.1 |
| Metabolic pathways | B3GALT5;MINPP1A;AK5;XYLB;HMBSA;SPHK2;GUK1;H6PD;NDST2 |
ADH4 has several biochemical functions, for example, NAD binding, NADPH:quinone reductase activity, alcohol dehydrogenase (NAD) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH4 itself. We selected most functions ADH4 had, and list some proteins which have the same functions with ADH4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD binding | CTBP2A;ADH4;UGDH;HIBADHB;IDH2;CTBP1;GPD1L;HPGD;HSD11B2 |
| NADPH:quinone reductase activity | TP53I3;CRYZ;ADH4;CRYZL1 |
| alcohol dehydrogenase (NAD) activity | ADH1A;ADH4;ADH5;ADH7;ADH8B;ADH6;DHRS9;ADH1;ADH1C |
| alcohol dehydrogenase activity, zinc-dependent | ADH1A;ADH1B;ADH7;ADH4 |
| alditol:NADP+ 1-oxidoreductase activity | PRKRA;AKR7A2;AKR1A1;ADH4;AKR1B7;AKR7A5;AKR1B1;AKR1B8;AKR1C2 |
| all-trans retinal binding | |
| benzaldehyde dehydrogenase activity | |
| ethanol binding | ADH7;ADH4;PRKCE;ADH1 |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | ALDH9A1A.1;ADH4;ALDH2.1;ALDH3A2B;ALDH9A1A.2;Aldh1a7;ALDH3A2A;ALDH2.2;ALDH9A1B |
| retinol binding | RBP5;RLBP1;RBP4;RBP1;LRAT;RBP3;RBP2;ADH7;CRABP2 |
| retinol dehydrogenase activity | HSD17B6;DHRS7C;DHRS3;SDR16C5;AKR1C3;RDH7;RDH12;RDH11;DHRS9 |
| zinc ion binding | TRIM61;KAT6B;PDZRN3B;ADAMTS15A;PRKCBP1L;TRIM35-19;SUV39H1A;TRIM27;SNCA |
ADH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH4.
RPL35
- Q&As
- Reviews
Q&As (10)
Ask a questionADH4 may have implications in the metabolism of other endogenous compounds or xenobiotics, suggesting its involvement in broader physiological functions.
Genetic variations or polymorphisms in the ADH4 gene may impact alcohol metabolism and susceptibility to alcohol-related disorders, emphasizing the role of genetic factors in its function.
ADH4 exhibits a tissue-specific expression pattern, and its expression is regulated by various factors such as transcriptional control and signaling pathways.
The enzymatic kinetics and catalytic properties of ADH4 contribute to its overall activity and efficiency in alcohol metabolism.
Exploring the consequences of ADH4 deficiency or overexpression provides insights into its role in alcohol metabolism and its impact on physiological processes.
ADH4 can efficiently metabolize different alcohol substrates, and its substrate specificity may differ from other ADH enzymes.
ADH4 expression and activity can be influenced by chronic alcohol exposure or withdrawal, and studying the underlying molecular mechanisms can shed light on alcohol-related effects.
Interacting proteins or cofactors can modulate the activity or function of ADH4, and investigating the molecular mechanisms involved can enhance our understanding of its regulation.
The activity or function of ADH4 can potentially be modulated by pharmacological agents or environmental factors, presenting potential therapeutic implications.
The structural features of ADH4 play a crucial role in its catalytic activity and binding affinity for alcohol, and understanding these features provides insights into its function.
Customer Reviews (2)
Write a reviewShows exceptional specificity in binding to DNA or RNA in nucleic acid binding assays.
Provides accurate and reliable quantification of protein isoforms in proteoforms analysis.
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