| Description : |
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293T |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Form : |
25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol. |
| Molecular Mass : |
41.3 kDa |
| AA Sequence : |
MFAEIQIQDKDRMGTAGKVIKCKAA VLWEQKQPFSIEEIEVAPPKTKEVR IKILATGICRTDDHVIKGTM VSKFPVIVGHEATGIVESIGEGVTT VKPGDKVIPLFLPQCRECNACRNPD GNLCIRSDITGRGVLADGTT RFTCKGKPVHHFMNTSTFTEYTVVD ESSVAKIDDAAPPEKVCLIGCGFST GYGAAVKTGKVKPGSTCVVF GLGGVGLSVIMGCKSAGASRIIGID LNKDKFEKAMAVGATECISPKDSTK PISEVLSEMTGNNVGYTFEV IGHLETMIDALASCHMNYGTSVVVG VPPSAKMLTYDPMLLFTGRTWKGCV FGGLKSRDDVPKLVTEFLAK KFDLDQLITHVLPFKKISEGFELLN SGQSIRTVLTF TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Notes : |
For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome |
| Protein Pathways : |
Drug metabolism - cytochrome P450, Fatty acid metabolism, Glycolysis / Gluconeogenesis, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism, Tyrosine metabolism |
