ADH6
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Official Full Name
alcohol dehydrogenase 6 (class V)
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Overview
This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5 UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ADH6; alcohol dehydrogenase 6 (class V); alcohol dehydrogenase 6; ADH 5; ADH 6; Aldehyde reductase; Class V alcohol dehydrogenase 6; UDP GLUCURONOSYLTRANSFERASE 2B10 PRECURSOR, MICROSOMAL; OTTHUMP00000161647; OTTHUMP00000161648; OTTHUMP00000161649; OTTHUMP00000220107; ADH-5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
ADH6 involved in several pathways and played different roles in them. We selected most pathways ADH6 participated on our site, such as Biological oxidations, Chemical carcinogenesis, Drug metabolism - cytochrome P450, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADH6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biological oxidations | ADH5;CYP2B6;CYP2K8;ADH1A;CYP1A1;CYP4B1;CYP3C1;CYP2K19;MTRR |
| Chemical carcinogenesis | UGT1A3;CCBL1;CYP2C70;AKR1C2;CYP1A1;CYP2C37;CYP2A13;CYP3A43;CYP3A41B |
| Drug metabolism - cytochrome P450 | GSTK1;ADH6;ADH2-2;ADH2-1;CYP2B6;ADH1C;CYP2D6;ADH1A;CYP2C19 |
| Ethanol oxidation | ADH5;ADH8A;ADH1C;ADH6;ADH1A;ADH8B;ADH7;ADH4;ADH1B |
| Fatty Acid Omega Oxidation | ADH7;CYP4A11;ADH4;ADH1B;CYP2E1;CYP2D6;ADH1C;ADH1A;CYP1A1 |
| Fatty acid degradation | HADH;ACSL4B;ACOX1;PECI;EHHADH;ACADVL;ACSL3A;ACSBG1;ACSL3B |
| Glycolysis / Gluconeogenesis | G6PC;ADH1;LDHC;ENO1A;ADH2-2;GM5506;PDHA1A;LDHA;ALDOC |
| Metabolic pathways | ACOX2;FUT7;RIMKLB;POLR3F;ACADVL;HSD11B1;EXT1C;AOC1;IDS |
ADH6 has several biochemical functions, for example, alcohol dehydrogenase (NAD) activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADH6 itself. We selected most functions ADH6 had, and list some proteins which have the same functions with ADH6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alcohol dehydrogenase (NAD) activity | ADH8B;ADH7;ADH1C;ADH6;ADH8A;ADH4;ADH1;DHRS9;ADH5 |
| zinc ion binding | TOPORS;RECQL4;FTR72;TRIM74;GTF2H2C;USP20;CAR13;ESR2B;DTNB |
ADH6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADH6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADH6.
TNIP1; ANKRD17; RSL1D1; KRAS; ARRB1; RPS29; RPAIN; RASSF5
- Q&As
- Reviews
Q&As (10)
Ask a questionExploring the consequences of ADH6 deficiency or overexpression provides insights into its role in alcohol metabolism and its impact on physiological processes related to alcohol-related disorders.
ADH6 exhibits a tissue-specific expression pattern, which may differ from other ADH isoforms, highlighting its unique role in specific tissues.
ADH6 can interact with specific partners or cofactors that modulate its activity or function, and studying the underlying molecular mechanisms elucidates its regulatory mechanisms.
ADH6 expression and activity can change in response to varying alcohol concentrations or exposure durations, and understanding the molecular mechanisms involved enhances our knowledge of alcohol-related effects.
ADH6 activity may be modulated by pharmacological agents or environmental factors, suggesting potential therapeutic implications and the possibility of targeting ADH6 in treatment strategies.
Investigating the structural features of ADH6 provides valuable information on its catalytic activity and binding properties, aiding in understanding its function.
ADH6 may participate in the metabolism of other endogenous compounds or xenobiotics, suggesting its involvement in broader physiological functions beyond alcohol metabolism.
ADH6 expression is regulated at the transcriptional and post-transcriptional levels by various factors and signaling pathways, providing insights into its regulation.
Genetic variations or polymorphisms in the ADH6 gene may impact alcohol metabolism and susceptibility to alcohol-related disorders, emphasizing the role of genetic factors in its function.
The enzymatic kinetics and substrate specificity of ADH6 contribute to its function in alcohol metabolism, enabling efficient conversion of specific alcohol substrates.
Customer Reviews (2)
Write a reviewProvides accurate and precise measurement of protein-ligand binding affinities in binding kinetics assays.
Shows outstanding performance in protein-protein docking simulations.
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