AGPAT1
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Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
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Overview
This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. -
Synonyms
AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha); 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; 1 AGPAT1; LPAAT alpha; LPAATA; MGC5423; 1 acyl sn glycerol 3 phosphate acyltransferase alpha; 1 acylglycerol 3 phosphate O acyltransferase 1 (acetoacetly Coenzyme A thiolase); 1 acylglycerol 3 phosphate O acyltransferase 1 (lysophosphatidic acid acyltransferase alpha); 1 acylglycerol 3 phosphate O acyltransferase 1; 1 AGP acyltransferase 1; AGPAT 1; G15; Lysophosphatidic acid acyltransferase alpha; Lysophospholipid acyltransferase; MGC4007; OTTHUMP00000062693; Protein G15; 1-AGPAT 1; 1-AGP acyltransferase 1; 1-acylglycerol-3-phosphate O-acyltransferase 1 (acetoacetly Coenzyme A thiolase); 1-AGPAT1; LPAAT-alpha;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Ovis aries (Sheep)
- Rhesus Macaque
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- AGPAT1 Related Articles
AGPAT1 involved in several pathways and played different roles in them. We selected most pathways AGPAT1 participated on our site, such as CDP-diacylglycerol biosynthesis, CDP-diacylglycerol biosynthesis I, ChREBP activates metabolic gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGPAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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CDP-diacylglycerol biosynthesis | GK5;AGPAT6;CDS1;GPAT2;AGPAT2;AGPAT1 |
CDP-diacylglycerol biosynthesis I | AGPAT1;AGPAT2 |
ChREBP activates metabolic gene expression | |
Fat digestion and absorption | PLA2G5;FABP2;Cel;CLPS;ACAT2;CD36;AGPAT1;PNLIPRP1;PLA2G2D |
Fatty acid, triacylglycerol, and ketone body metabolism | CDK8;ACAD11;SLC25A20;MED25;AGPAT6;Agmo;ESRRA;TIAM2;ACOT9.2 |
Glycerolipid metabolism | MOGAT3A;PPAP2D;DGKG;GPAM;AGK;MOGAT2;ALDH9A1B;ALDH9A1;ALDH2.2 |
Glycerophospholipid biosynthesis | BCHE;PLD6;CHKB;CDS1;CHAT;CPNE1;PLA2G16;CPNE3;CDIPT |
Glycerophospholipid metabolism | PLA2G12B;GPD1A;GPCPD1;TAE1;LPCAT4;MBOAT2;LPIN1;LCLAT1;EPT1 |
AGPAT1 has several biochemical functions, for example, 1-acylglycerol-3-phosphate O-acyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGPAT1 itself. We selected most functions AGPAT1 had, and list some proteins which have the same functions with AGPAT1. You can find most of the proteins on our site.
Function | Related Protein |
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1-acylglycerol-3-phosphate O-acyltransferase activity | AGPAT5;ABHD5;AGPAT1;LYCAT;AGPAT3;LPCAT2;AGPAT9L;AGPAT4;AGPAT2 |
protein binding | TRIM16;MKNK2;PRPF3;PLEKHB1;UNC119B;IMP3;PHF17;MOCOS;VASP |
AGPAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGPAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGPAT1.
MEOX2; Hoxa1; MYC
- Q&As
- Reviews
Q&As (20)
Ask a questionAGPAT1 catalyzes the acylation of glycerol-3-phosphate, a key step in phospholipid synthesis.
Yes, AGPAT1 is essential for proper lipid metabolism and cellular membrane synthesis.
AGPAT1 contributes to phospholipid biosynthesis and remodeling pathways.
AGPAT1’s activity is linked to insulin sensitivity and glucose metabolism.
AGPAT1’s involvement in lipid metabolism influences energy storage and utilization.
Yes, AGPAT1 mutations can result in metabolic disorders and lipodystrophic phenotypes.
Yes, AGPAT1’s function can be influenced by cellular stress and metabolic challenges.
AGPAT1 adds fatty acids to glycerol-3-phosphate, producing lysophosphatidic acid (LPA).
Yes, AGPAT1 is a potential target for modulating lipid metabolism in metabolic disorders.
Yes, AGPAT1’s activity is linked to adipocyte differentiation and fat cell formation.
Research investigates AGPAT1’s contribution to de novo lipogenesis and fatty acid synthesis.
Research investigates AGPAT1’s role in lipid biosynthesis pathways.
Yes, AGPAT1’s role can impact the formation and turnover of lipid droplets.
Yes, AGPAT1’s involvement in lipid synthesis can influence membrane fusion and trafficking.
Research explores AGPAT1’s involvement in triglyceride synthesis and energy storage.
Yes, post-translational modifications can modulate AGPAT1’s activity.
Yes, AGPAT1’s function contributes to the composition of cellular membranes and lipid homeostasis.
Research explores how AGPAT1 affects the lipid composition of different tissues.
Mutations in AGPAT1 can cause lipodystrophy, a disorder affecting fat tissue distribution.
AGPAT1’s function is a critical step in the biosynthesis of glycerolipids like phosphatidic acid.
Customer Reviews (5)
Write a reviewConsistently achieving specific outcomes validated the crucial role of the product in our studies.
Comprehensive documentation streamlined our incorporation of the product into our research workflow.
The product’s distinct features advanced our research into uncharted territories.
Despite its cost, the insights gained from the product’s usage made it a worthy investment.
The observed changes in cell morphology were directly attributed to the product’s effectiveness.
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