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AGPAT1

  • Official Full Name

    1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)

  • Overview

    This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein.
  • Synonyms

    AGPAT1; 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha); 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; 1 AGPAT1; LPAAT alpha; LPAATA; MGC5423; 1 acyl sn glycerol 3 phosphate acyltransferase alpha; 1 acylglycerol 3 phosphate O acyltransferase 1 (acetoacetly Coenzyme A thiolase); 1 acylglycerol 3 phosphate O acyltransferase 1 (lysophosphatidic acid acyltransferase alpha); 1 acylglycerol 3 phosphate O acyltransferase 1; 1 AGP acyltransferase 1; AGPAT 1; G15; Lysophosphatidic acid acyltransferase alpha; Lysophospholipid acyltransferase; MGC4007; OTTHUMP00000062693; Protein G15; 1-AGPAT 1; 1-AGP acyltransferase 1; 1-acylglycerol-3-phosphate O-acyltransferase 1 (acetoacetly Coenzyme A thiolase); 1-AGPAT1; LPAAT-alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Rhesus Macaque
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AGPAT1-427H Recombinant Human AGPAT1 Protein, GST-tagged Wheat Germ GST
Human AGPAT1-36HCL Recombinant Human AGPAT1 cell lysate N/A
Human AGPAT1-1000HF Recombinant Full Length Human AGPAT1 Protein, GST-tagged In Vitro Cell Free System GST 283 amino acids
Mouse AGPAT1-1417M Recombinant Mouse AGPAT1 Protein Mammalian Cell His
Mouse AGPAT1-389M Recombinant Mouse AGPAT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse AGPAT1-389M-B Recombinant Mouse AGPAT1 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL19672BF Recombinant Full Length Bovine 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Alpha(Agpat1) Protein, His-Tagged E.coli expression system His Full Length (1-287)
Homo sapiens (Human) RFL28606HF Recombinant Full Length Human 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Alpha(Agpat1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (27-283)
Mus musculus (Mouse) RFL-22298MF Recombinant Full Length Mouse 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Alpha(Agpat1) Protein, His-Tagged E.coli expression system His Full Length (1-285)
Ovis aries (Sheep) RFL15510OF Recombinant Full Length Sheep 1-Acyl-Sn-Glycerol-3-Phosphate Acyltransferase Alpha(Agpat1) Protein, His-Tagged E.coli expression system His Full Length (1-287)
Rhesus Macaque AGPAT1-271R Recombinant Rhesus monkey AGPAT1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AGPAT1-99R Recombinant Rhesus Macaque AGPAT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AGPAT1-99R-B Recombinant Rhesus Macaque AGPAT1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AGPAT1 Related Articles

AGPAT1 involved in several pathways and played different roles in them. We selected most pathways AGPAT1 participated on our site, such as CDP-diacylglycerol biosynthesis, CDP-diacylglycerol biosynthesis I, ChREBP activates metabolic gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGPAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
CDP-diacylglycerol biosynthesisGK5;AGPAT6;CDS1;GPAT2;AGPAT2;AGPAT1
CDP-diacylglycerol biosynthesis IAGPAT1;AGPAT2
ChREBP activates metabolic gene expression
Fat digestion and absorptionPLA2G5;FABP2;Cel;CLPS;ACAT2;CD36;AGPAT1;PNLIPRP1;PLA2G2D
Fatty acid, triacylglycerol, and ketone body metabolismCDK8;ACAD11;SLC25A20;MED25;AGPAT6;Agmo;ESRRA;TIAM2;ACOT9.2
Glycerolipid metabolismMOGAT3A;PPAP2D;DGKG;GPAM;AGK;MOGAT2;ALDH9A1B;ALDH9A1;ALDH2.2
Glycerophospholipid biosynthesisBCHE;PLD6;CHKB;CDS1;CHAT;CPNE1;PLA2G16;CPNE3;CDIPT
Glycerophospholipid metabolismPLA2G12B;GPD1A;GPCPD1;TAE1;LPCAT4;MBOAT2;LPIN1;LCLAT1;EPT1

AGPAT1 has several biochemical functions, for example, 1-acylglycerol-3-phosphate O-acyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGPAT1 itself. We selected most functions AGPAT1 had, and list some proteins which have the same functions with AGPAT1. You can find most of the proteins on our site.

Function Related Protein
1-acylglycerol-3-phosphate O-acyltransferase activityAGPAT5;ABHD5;AGPAT1;LYCAT;AGPAT3;LPCAT2;AGPAT9L;AGPAT4;AGPAT2
protein bindingTRIM16;MKNK2;PRPF3;PLEKHB1;UNC119B;IMP3;PHF17;MOCOS;VASP

AGPAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGPAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGPAT1.

MEOX2; Hoxa1; MYC

Benatti, RO; Melo, AM; et al. Maternal high-fat diet consumption modulates hepatic lipid metabolism and microRNA-122 (miR-122) and microRNA-370 (miR-370) expression in offspring. BRITISH JOURNAL OF NUTRITION 111:2112-2122(2014).
Guan, WH; Steffen, BT; et al. Genome-Wide Association Study of Plasma N6 Polyunsaturated Fatty Acids Within the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. CIRCULATION-CARDIOVASCULAR GENETICS 7:321-331(2014).
  • Q&As
  • Reviews

Q&As (20)

Ask a question
What’s the role of AGPAT1 in lipid metabolism 12/20/2022

AGPAT1 catalyzes the acylation of glycerol-3-phosphate, a key step in phospholipid synthesis.

Is AGPAT1 essential for normal cellular function 12/03/2022

Yes, AGPAT1 is essential for proper lipid metabolism and cellular membrane synthesis.

How does AGPAT1’s role intersect with phospholipid remodeling 10/29/2022

AGPAT1 contributes to phospholipid biosynthesis and remodeling pathways.

How does AGPAT1’s function relate to insulin sensitivity 07/18/2022

AGPAT1’s activity is linked to insulin sensitivity and glucose metabolism.

How does AGPAT1’s role affect energy storage and utilization 03/11/2022

AGPAT1’s involvement in lipid metabolism influences energy storage and utilization.

Can AGPAT1’s dysfunction lead to metabolic disorders 12/11/2021

Yes, AGPAT1 mutations can result in metabolic disorders and lipodystrophic phenotypes.

Can AGPAT1’s activity influence cellular response to stress 07/27/2021

Yes, AGPAT1’s function can be influenced by cellular stress and metabolic challenges.

How does AGPAT1 participate in glycerolipid synthesis 04/01/2021

AGPAT1 adds fatty acids to glycerol-3-phosphate, producing lysophosphatidic acid (LPA).

Can AGPAT1 be targeted for therapeutic interventions 01/04/2021

Yes, AGPAT1 is a potential target for modulating lipid metabolism in metabolic disorders.

Can AGPAT1 impact adipocyte differentiation 12/02/2020

Yes, AGPAT1’s activity is linked to adipocyte differentiation and fat cell formation.

How is AGPAT1’s connection to lipogenesis studied 10/29/2020

Research investigates AGPAT1’s contribution to de novo lipogenesis and fatty acid synthesis.

How is AGPAT1’s involvement in glycerophospholipid metabolism studied 12/07/2019

Research investigates AGPAT1’s role in lipid biosynthesis pathways.

Can AGPAT1 contribute to the regulation of lipid droplet formation 04/19/2019

Yes, AGPAT1’s role can impact the formation and turnover of lipid droplets.

Can AGPAT1 play a role in membrane fusion processes 12/10/2018

Yes, AGPAT1’s involvement in lipid synthesis can influence membrane fusion and trafficking.

How is AGPAT1’s role in triglyceride synthesis studied 07/12/2018

Research explores AGPAT1’s involvement in triglyceride synthesis and energy storage.

Can AGPAT1’s function be regulated by post-translational modifications 12/25/2017

Yes, post-translational modifications can modulate AGPAT1’s activity.

Can AGPAT1’s activity affect cellular membranes 09/09/2017

Yes, AGPAT1’s function contributes to the composition of cellular membranes and lipid homeostasis.

How is AGPAT1’s role in lipid composition of tissues studied 08/01/2016

Research explores how AGPAT1 affects the lipid composition of different tissues.

How does AGPAT1’s function relate to lipodystrophy 05/24/2016

Mutations in AGPAT1 can cause lipodystrophy, a disorder affecting fat tissue distribution.

How is AGPAT1’s role connected to glycerolipid biosynthesis? 01/18/2016

AGPAT1’s function is a critical step in the biosynthesis of glycerolipids like phosphatidic acid.

Customer Reviews (5)

Write a review
Reviews
02/28/2019

     Consistently achieving specific outcomes validated the crucial role of the product in our studies.

    08/19/2018

       Comprehensive documentation streamlined our incorporation of the product into our research workflow.

      07/21/2017

         The product’s distinct features advanced our research into uncharted territories.

        07/05/2017

           Despite its cost, the insights gained from the product’s usage made it a worthy investment.

          01/16/2016

             The observed changes in cell morphology were directly attributed to the product’s effectiveness.

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