AGXT
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Official Full Name
alanine-glyoxylate aminotransferase -
Overview
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. -
Synonyms
AGXT;alanine-glyoxylate aminotransferase;SPAT;serine--pyruvate aminotransferase;AGT;AGT1;AGXT1;glycolicaciduria;L alanine: glyoxylate aminotransferase 1;oxalosis I;PH1;primary hyperoxaluria type 1;serine:pyruvate aminotransferase;SPT;serine-
Recombinant Proteins
- Human
- Rat
- Mouse
- HEK293
- E.coli
- Wheat Germ
- Mammalian Cells
- Yeast
- Mouse
- DDK
- Myc
- GST
- Non
- His
- Avi
- Fc
- SUMO
Involved Pathway
AGXT involved in several pathways and played different roles in them. We selected most pathways AGXT participated on our site, such as Alanine and aspartate metabolism,Alanine, aspartate and glutamate metabolism,Biosynthesis of antibiotics, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGXT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glyoxylate metabolism and glycine degradation | DAO,DAO1 |
| Glyoxylate and dicarboxylate metabolism | GLYCTK,SHMT1,ACO1,GLDC,DLDH,ACAT2,GLULC,AFMID,HAO1,GRHPRB |
| Metabolic pathways | RDH11,PLA2G4C,INPP5E,HPSE2,ACAD8,PAPSS2,CYP11B2,CYP2C8,PPT1,POLR1E |
| Glycine, serine and threonine metabolism | PHGDH,CBSA,PIPOX,AGXTA,GCSHA,GLYCTK,LSM1,DAO1,CBSB,GNMT |
| Alanine, aspartate and glutamate metabolism | IL4I1,CPS1,GOT1,NAT8L,GLUD2,GAD1,ABAT,GOT2A,AGXTB,GOT2B |
| Alanine and aspartate metabolism | DARS,ABAT |
| Biosynthesis of antibiotics | ECHS1,AK7,GPR19,GLYCTK,EHHADH,DLD,CTH,AK8,SDS,LDHAL6B |
| Carbon metabolism | GM5506,ANI_1_2390104,IDH3A,ECHS1,GOT2,SDHC,ACADM,GPI1,PRPS1B,GPR19 |
Protein Function
AGXT has several biochemical functions, for example, alanine-glyoxylate transaminase activity,amino acid binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGXT itself. We selected most functions AGXT had, and list some proteins which have the same functions with AGXT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pyridoxal phosphate binding | KYNU,PYGB,ABAT,GAD1B,GOT2B,AGXT2L1,PROSC,GAD1,DDC,SRR |
| protein binding | RPS6KA1,SMAD4,CAMLG,ELP3,RTN4R,ARHGAP33,IRAK1BP1,Abcb1b,TNF,EP300 |
| alanine-glyoxylate transaminase activity | AGXTA,AGXT2,AGXTB |
| protein homodimerization activity | IRAK3,CEBPB,NPR3,GIPC1,SLC24A6,ABCG1,HER5,UXS1,NPM1,LHPP |
| serine-pyruvate transaminase activity | AGXTA,AGXTB |
| amino acid binding | SHMT2,GCHFR,TPH1A,TPH1B,GOT2,DDAH1,AARS,DDAH2,TDO2,KARS |
| receptor binding | CCDC129,PVRL3B,DAO1,HLA-B,GFRA1,TAC4,EDN3,EPB49,RSPO3,LGI1 |
| transaminase activity | PHYKPL,CCBL1,GPT2L,AGXT2L2,AGXT2L1,GOT2B,GOT1L1,AGXTB,AMT,ETNPPL |
| protein self-association | TP53,TNFAIP3,DYRK1A,BCL10,TTN,CNTN2,AGTR1A,LDB1,RYR2,EPB49 |
Interacting Protein
AGXT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGXT here. Most of them are supplied by our site. Hope this information will be useful for your research of AGXT.
ACAT1;SNCAIP
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