agxt
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  • Official Full Name
  • alanine-glyoxylate aminotransferase
  • Background
  • This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria.
  • Synonyms
  • AGXT; alanine-glyoxylate aminotransferase; SPAT; serine--pyruvate aminotransferase; AGT; AGT1; AGXT1; glycolicaciduria; L alanine: glyoxylate aminotransferase 1; oxalosis I; PH1; primary hyperoxaluria type 1; serine:pyruvate aminotransferase; SPT; serine-
Cat.#:AGXT-503HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGXT Protein, His-tagged
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Cat.#:Agxt-504MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Agxt Protein, His-tagged
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Cat.#:Agxt-505RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Agxt Protein, His-tagged
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Cat.#:AGXT-26660THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human AGXT
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Cat.#:AGXT-450HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AGXT Protein, GST-tagged
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Cat.#:AGXT-84837HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGXT, MYC/DDK-tagged
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Cat.#:AGXT-84838HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGXT, His-tagged
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Cat.#:AGXT-9487HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AGXT, GST-tagged
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Cat.#:AGXT-569RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AGXT Protein
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Cat.#:AGXT-8967HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human AGXT 293 Cell Lysate
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Involved Pathway

AGXT involved in several pathways and played different roles in them. We selected most pathways AGXT participated on our site, such as Alanine and aspartate metabolism, Alanine, aspartate and glutamate metabolism, Biosynthesis of antibiotics, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGXT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alanine and aspartate metabolism
DARS; ABAT; AGXT
Alanine, aspartate and glutamate metabolism
ADSL; ybaS; NAT8L; GPT2L; PPAT; GOT1; GAD2; GLULA; GPT; GAD1B
Biosynthesis of antibiotics
UAP1L1; EHHADH; SDSL; DLD; SDS; ECHS1; CS; DBT; ADH5; NME6
Carbon metabolism
ACO1; ME3; EHHADH; SDHB; FH1; ALDOCB; GPIB; OGDHL; MDH1AA; PGAM2
Glycine, serine and threonine metabolism
GLYCTK; AMT; TDH; PSPH; AOC2; BHMT; CBS; SDSL; DMGDH; GATM
Glyoxylate and dicarboxylate metabolism
ACO2; SHMT1; CS; AGXT; HAO2; MCEE; HOGA1; GCSHB; PGP; MDH1
Glyoxylate metabolism and glycine degradation
AGXT; DAO1; DAO
Metabolic pathways
PGAM1; MAT2A; GLS; ALDH9A1; HPDA; LIPT2; EARS2; COX7C; SDS; PRPS1B

Protein Function

AGXT has several biochemical functions, for example, alanine-glyoxylate transaminase activity, amino acid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGXT itself. We selected most functions AGXT had, and list some proteins which have the same functions with AGXT. You can find most of the proteins on our site.
Function
Related Protein
Function alanine-glyoxylate transaminase activity
Related Protein AGXT; AGXTA; AGXTB; AGXT2
Function amino acid binding
Related Protein DDAH2; DDAH1; TAT; AGXT; DPYS; TPH2; ASS1; SHMT2; OTC; AARS
Function protein binding
Related Protein NT5C3B; TRIM6; NLRC4; FAM3C; TBC1D23; SLC30A3; KCNA2; Clec4n; MYO7A; ERAL1
Function protein homodimerization activity
Related Protein TFAP2E; HIF1AN; SNX1; CEACAM1; KLHL7; TFAP2B; CBLN1; GALE; TG; PEX11A
Function protein self-association
Related Protein EPB49; LDB1; CTSC; PTH1R; AGXT; CCDC88C; PABPN1; AXIN1; ZSWIM2; PCSK9
Function pyridoxal phosphate binding
Related Protein LOC650128; GAD1; MARC1; SHMT2; GPT; AADAT; CCBL2; GPT2; PDXDC2P; GPT2L
Function receptor binding
Related Protein PTK2AA; ENSA; NRG3; H2-Q10; GCG; TYROBP; C1QTNF2; PLG; FYNA; EPB49
Function serine-pyruvate transaminase activity
Related Protein AGXT; AGXTA; AGXTB
Function transaminase activity
Related Protein CCBL1; AMT; AGXT2L1; AGXT2; AGXTB; AGXTA; GOT1L1; GOT2A; GOT2B; AGXT2L2

Interacting Protein

AGXT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGXT here. Most of them are supplied by our site. Hope this information will be useful for your research of AGXT.
ACAT1; SNCAIP