AKAP5
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Official Full Name
A kinase (PRKA) anchor protein 5 -
Overview
AKAPs (A-kinase anchoring proteins), as their name implies, are a family of scaffolding proteins that bind regulatory subunits of Protein Kinase A (PKA) thus localizing PKA activity to distinct regions of the cell (1). Beyond a common amphipathic alpha he -
Synonyms
AKAP5;A kinase (PRKA) anchor protein 5;A-kinase anchor protein 5;AKAP75;AKAP79;AKAP-5;AKAP 79;A-kinase anchor protein 79 kDa;A-kinase anchor protein, 79kDa;A-kinase anchoring protein 75/79;cAMP-dependent protein kinase regulatory subunit II high
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cells
- HEK293
- E.Coli/Yeast
- Wheat Germ
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AKAP5-1479M | Recombinant Mouse AKAP5 Protein | Mammalian Cells | Mouse | His |
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| AKAP5-23H | Recombinant Human AKAP5, His-tagged | HEK293 | Human | His | 1-427 a.a. |
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| Akap5-3029R | Recombinant Rat Akap5, His-tagged | E.Coli/Yeast | Rat | His | 714 |
|
| AKAP5-3030H | Recombinant Human AKAP5, His-tagged | E.Coli/Yeast | Human | His | 427 |
|
| AKAP5-401H | Recombinant Human AKAP5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| AKAP5-714H | Recombinant Human AKAP5 | Mammalian Cells | Human | His |
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| AKAP5-8939HCL | Recombinant Human AKAP5 293 Cell Lysate | HEK293 | Human | Non |
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| Akap5-110M | Recombinant Mouse Akap5 Protein, His&GST-tagged | E.coli | Mouse | GST&His | Met1-Gln161 |
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| AKAP5-1349HF | Recombinant Full Length Human AKAP5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 427 amino acids |
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| AKAP5-2451H | Recombinant Human AKAP5 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| AKAP5-2451H-B | Recombinant Human AKAP5 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| AKAP5-431M | Recombinant Mouse AKAP5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| AKAP5-431M-B | Recombinant Mouse AKAP5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
AKAP5 involved in several pathways and played different roles in them. We selected most pathways AKAP5 participated on our site, such as Calcium signaling in the CD4+ TCR pathway,G Protein Signaling Pathways,Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | NSFA,CACNG3,MYO6,CACNG2,NSFB,GRIP1,PICK1,HAND2 |
| Calcium signaling in the CD4+ TCR pathway | JUNB,RCAN1,CSF2,FKBP1A,BATF3,RCAN2,CHP,POU2F1 |
| Integration of energy metabolism | ARL2,GNG13A,KCNB1,ARL2BP,GNB5A,RAPGEF4,KCNJ11,KCNS3,RAPGEF3,KCNS3A |
| G Protein Signaling Pathways | GNGT2A,AKAP13,AKAP8,AKAP6,GNB5B,AKAP1,GNA13,GNB3B,ARHGEF1A,Akap3 |
| Neuronal System | KCNAB1,KCND3,KCNA1,KCNA7,KCNN3,BCHE,DLG3,KCNN4,DLG1L,KCNC1B |
| Metabolism | NUDT3B,TIMMDC1,ATP5H,CYP2K17,AQP1A.2,CYP2R1,GCKR,COQ6,KCNJ11,GRX2 |
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | NSFB,NCALDA,CHRNA2,GRIP1,GABRR2A,MYO6,HAND2,CHRND,DLG1L,CHRNE |
Protein Function
AKAP5 has several biochemical functions, for example, G-protein coupled receptor binding,GABA receptor binding,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP5 itself. We selected most functions AKAP5 had, and list some proteins which have the same functions with AKAP5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GABA receptor binding | PPP2CA,PLCL2,ARFGEF2,GABRA5,MAF1,JAKMIP1,GABRB1,GABARAPL2,GABARAP,GABARAPL1 |
| G-protein coupled receptor binding | FYN,APLN,ITGB4,UTS2D,ARHGEF12,PARK2,RSPO3,GNA13B,RSPO2,USP33 |
| protein kinase A regulatory subunit binding | ARFGEF2,KCNQ1,RYR2,AKAP9,PJA2,AKAP8,C2orf88,AKAP6,ACBD3,EZR |
| actin binding | CAPG,FLNC,AVIL,FSCN2B,CFL2L,ACTN4,FXYD5,INPPL1,TBC1D21,IPP |
| protein complex binding | AP2A2,MTAP1B,NCK2,CDK5RAP1,PPFIA2,UQCRC2,PDX1,CRHR1,ANKRD54,TXN2 |
| protein kinase binding | CAMK2N1A,CD226,NBEA,SKAP1,MAP3K5,CALM,DUSP3,TP73,HDAC4,RFFL |
| protein kinase A binding | LRRK2,AKAP17A,AKAP13,AKAP14,DACT3,Akap3,RPS3,AKAP12B,DACT1,AKAP6 |
| calmodulin binding | GM101,REM1,MAP6D1,GAP43,ADD1,RGS16,RYR1,CNN1A,PCP4,RIT1 |
| protein binding | HSBP1,LSM10,ISG20L2,DMD,STAG3,SLC25A6,DSCAM,KCNQ1,HSPB11,PSMD7 |
Interacting Protein
AKAP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP5.
PRKAR2A;PRKACA;PRKACB;Kcnj2;KCNJ2;RXFP1;MRPL43;DERL1;2_aha_camp;8-aha-camp;8-aha-omethyladenosine;HSPA8;SUV39H1;SLC25A12
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References
- Hong, GE; Kim, JA; et al. Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF-kappa B and MAPK in RAW 264.7 Cells. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE :-(2013).
- Huang, ZH; Somanath, PR; et al. Changes in intracellular distribution and activity of protein phosphatase PP1 gamma 2 and its regulating proteins in spermatozoa lacking AKAP4. BIOLOGY OF REPRODUCTION 72:384-392(2005).
