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Official Full Name AKT1 substrate 1 (proline-rich)
Background PRAS40 (proline-rich Akt substrate of 40 kDa) is a protein with a prolin-rich domain and appears at about 40 kDa by SDS-PAGE. Initially it was identified as a substrate of PKB/Akt, it was later shown that it is also phosphorylated by mTORC1 (a complex including scaffold protein which is necessary for mTOR and phosphorylation of substrate by mTOR). PRAS40 binds to raptor through the mediation of TOS-motif in its structure in the same way as p70 S6 kinase and 4E-P1 do as substrates of mTOR , then PRAS40 is phosphorylated by mTORC1 at Ser-183 (human), and the phosphorylated PRAS40 will be dissociated from raptor. Therefore, it is considered that PRAS40 is involved in signal-transducing pathway through the mediation of not only PKB/Akt but also mTOR.
Synonyms AKT1S1; AKT1 substrate 1 (proline-rich); Lobe; PRAS40; proline-rich AKT1 substrate 1; 40 kDa proline-rich AKT substrate; proline-rich Akt substrate, 40 kDa; OTTHUMP00000196757; PRAS40; OTTHUMP00000196758; Lobe; OTTHUMP00000196759; MGC2865; OTTHUMP00000196760; OTTHUMP00000196756; proline-rich Akt substrate of 40 kDa
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • Myc/DDK
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKT1S1-1484H Recombinant Human AKT1S1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human AKT1S1-15HCL Recombinant Human AKT1S1 lysate HEK293 N/A
    Human AKT1S1-1854H Recombinant Human AKT1 Substrate 1 (proline-rich), His-tagged And Myc-tagged E.coli His/Myc
    Human AKT1S1-1934H Recombinant Human AKT1S1, GST-tagged E.coli GST
    Human AKT1S1-2377H Recombinant Human AKT1 Substrate 1 (Proline-rich) E.coli N/A
    Human AKT1S1-25H Recombinant Human AKT1S1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human AKT1S1-26H Recombinant Human AKT1S1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human AKT1S1-27H Recombinant Human AKT1S1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human AKT1S1-4083H Recombinant Human AKT1S1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human AKT1S1-423H Recombinant Human AKT1S1 Protein, GST-tagged Wheat Germ GST
    Mouse AKT1S1-1508M Recombinant Mouse AKT1S1 Protein Mammalian Cell His
    Mouse Akt1s1-1585M Recombinant Mouse Akt1s1 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    AKT1S1 involved in several pathways and played different roles in them. We selected most pathways AKT1S1 participated on our site, such as mTOR signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT1S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    mTOR signaling pathway TSC2; EIF4EA; INS2; AKT1; EIF4E2RS1; MAPK1; PRR5; PRKCBB; PIK3CA; RPS6KA6
    AMPK signaling pathway PRKAA2; RAB10; CREB3L3; PPP2R2B; RHEB; IGF1R; Scd2; CAMKK2; PIK3CB; PRKAA1

    AKT1S1 has several biochemical functions, for example, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT1S1 itself. We selected most functions AKT1S1 had, and list some proteins which have the same functions with AKT1S1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding O3far1; PIKFYVE; HIST1H4J; CBLL1; CD58; TALDO1; WDR34; VPS4A; CTAGE5; KRTAP13-3
    zinc ion binding DTNB; PHF7; RARB; LANCL1; RNF43; ZNF8; MMP15; MYLIP; ADAM23; MMP26

    AKT1S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT1S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT1S1.

    MTOR; RPTOR; BMH1; YWHAB; YWHAH; YWHAZ; RPS6KA5; ITGB3BP; TCEA2; q81wa0_bacan; hisJ

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