AKT1S1
-
Official Full Name
AKT1 substrate 1 (proline-rich)
-
Overview
PRAS40 (proline-rich Akt substrate of 40 kDa) is a protein with a prolin-rich domain and appears at about 40 kDa by SDS-PAGE. Initially it was identified as a substrate of PKB/Akt, it was later shown that it is also phosphorylated by mTORC1 (a complex including scaffold protein which is necessary for mTOR and phosphorylation of substrate by mTOR). PRAS40 binds to raptor through the mediation of TOS-motif in its structure in the same way as p70 S6 kinase and 4E-P1 do as substrates of mTOR , then PRAS40 is phosphorylated by mTORC1 at Ser-183 (human), and the phosphorylated PRAS40 will be dissociated from raptor. Therefore, it is considered that PRAS40 is involved in signal-transducing pathway through the mediation of not only PKB/Akt but also mTOR. -
Synonyms
AKT1S1; AKT1 substrate 1 (proline-rich); Lobe; PRAS40; proline-rich AKT1 substrate 1; 40 kDa proline-rich AKT substrate; proline-rich Akt substrate, 40 kDa; OTTHUMP00000196757; PRAS40; OTTHUMP00000196758; Lobe; OTTHUMP00000196759; MGC2865; OTTHUMP00000196760; OTTHUMP00000196756; proline-rich Akt substrate of 40 kDa;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|Myc
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- AKT1S1 Related Research Area
- AKT1S1 Related Signal Pathway
AKT1S1 involved in several pathways and played different roles in them. We selected most pathways AKT1S1 participated on our site, such as mTOR signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT1S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
mTOR signaling pathway | RRAGD;AKT2L;INS1;IRS1;DDIT4;RPS6;PIK3R2;PIK3R5;PIK3CG |
AMPK signaling pathway | CREB3L3;CPT1B;PPP2R3C;RAB14;STRADB;PIK3CA;TBC1D1;AKT1S1;ADIPOQ |
AKT1S1 has several biochemical functions, for example, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT1S1 itself. We selected most functions AKT1S1 had, and list some proteins which have the same functions with AKT1S1. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
protein binding | CCT3;PALM;ACTN4;COPS8;VSTM2L;DDI1;POU2F3;PDK1;GSTK1 |
zinc ion binding | RNF220A;LHX8A;SF1;NR6A1;ZCCHC11;TCEA1;USP5;TRIM54;SMAD3 |
AKT1S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT1S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT1S1.
MTOR; RPTOR; BMH1; YWHAB; YWHAH; YWHAZ; RPS6KA5; ITGB3BP; TCEA2; q81wa0_bacan; hisJ
- Q&As
- Reviews
Q&As (11)
Ask a questionMutations in AKT1S1 have been identified in specific types of cancer, particularly endometrial cancer. These mutations can lead to alterations in AKT1S1 function, affecting its interaction with AKT1 and modulating downstream signaling pathways. However, further studies are needed to fully understand the extent and significance of AKT1S1 mutations in disease development and progression.
AKT1S1 protein regulates various cellular processes, including cell growth, proliferation, survival, protein synthesis, and autophagy. By modulating the activity of AKT1, AKT1S1 influences downstream signaling pathways involved in these processes.
Currently, there are no specific known inhibitors or activators of AKT1S1 that have been developed or approved for therapeutic use. Since AKT1S1 interacts with AKT1 and acts as an endogenous regulator of its activity, modulating AKT1S1 function indirectly affects AKT1 signaling.
AKT1S1 interacts with AKT1 through a protein-protein interaction. AKT1S1 contains a binding domain that recognizes specific regions on AKT1, allowing them to interact and form a complex. This interaction inhibits the activity of AKT1 kinase and regulates its downstream signaling.
The role of AKT1S1 as an oncogene or tumor suppressor is still not fully understood and may vary depending on the context. While some studies suggest that AKT1S1 can act as a tumor suppressor by inhibiting AKT1 activity and suppressing cell growth and proliferation, other studies indicate that AKT1S1 can have oncogenic properties. Mutations in AKT1S1 have been found in certain cancers, including endometrial cancer, which suggests that aberrant AKT1S1 function may contribute to tumorigenesis. Further research is needed to clarify the exact role of AKT1S1 in cancer development and progression.
AKT1S1 protein is regulated through multiple mechanisms. One of the key modes of regulation is phosphorylation. Phosphorylation of specific sites on AKT1S1 can either positively or negatively regulate its interaction with AKT1.
Currently, there are no specific drugs or compounds that directly target AKT1S1 for therapeutic purposes. However, considering its role in regulating AKT1 activity and downstream signaling, targeting AKT1 itself through selective inhibitors may indirectly affect AKT1S1 function.
AKT1S1 plays a role in cell growth and proliferation by regulating the activity of AKT1. AKT1 is a kinase that promotes cell survival and growth by activating various downstream signaling pathways. AKT1S1, when bound to AKT1, inhibits its kinase activity and suppresses cell growth and proliferation. However, upon phosphorylation by mTORC1, AKT1S1 dissociates from AKT1, allowing AKT1 to become active and stimulate cell growth and proliferation.
AKT1S1 plays a role in the regulation of autophagy, a cellular process involved in the degradation and recycling of damaged or unnecessary cellular components. AKT1S1 can influence autophagy through its interaction with AKT1 and mTORC1. When AKT1S1 is phosphorylated by mTORC1, it dissociates from AKT1, resulting in AKT1 activation. Activated AKT1, in turn, inhibits autophagy by suppressing the activity of ULK1 (Unc-51-like autophagy-activating kinase 1), a key kinase involved in the initiation of autophagy.
In addition to the processes mentioned earlier, AKT1S1 is also involved in the regulation of insulin signaling and glucose metabolism. Insulin activates AKT1, which, in turn, phosphorylates AKT1S1, leading to its dissociation from AKT1. This allows AKT1 to promote glucose uptake and metabolism in cells. AKT1S1 has also been implicated in the regulation of lipid metabolism and adipogenesis, particularly through its interaction with mTORC1 and peroxisome proliferator-activated receptor gamma (PPARγ).
The dysregulation of AKT1S1 has been implicated in various diseases, including cancer and metabolic disorders. Therefore, targeting AKT1S1 could have therapeutic implications.
Customer Reviews (4)
Write a reviewthe AKT1S1 protein has proven to be an invaluable tool in protein electron microscopy structure analysis.
I highly recommend the AKT1S1 protein for a variety of research applications.
Great performance in ELISA.
It demonstrates excellent performance in ELISA, consistently delivering accurate and reliable results.
Ask a Question for All AKT1S1 Products
Required fields are marked with *
My Review for All AKT1S1 Products
Required fields are marked with *