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Official Full Name aldehyde dehydrogenase 1 family, member L1
Background The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.
Synonyms ALDH1L1; aldehyde dehydrogenase 1 family, member L1; formyltetrahydrofolate dehydrogenase , FTHFD; cytosolic 10-formyltetrahydrofolate dehydrogenase; 10 fTHF; cytosolic 10 formyltetrahydrofolate dehydrogenase; 10-FTHFDH; formyltetrahydrofolate dehydrogena
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALDH1L1-17HCL Recombinant Human ALDH1L1 lysate HEK293 N/A
    Human ALDH1L1-442H Recombinant Human ALDH1L1 Protein, GST-tagged Wheat Germ GST
    Human ALDH1L1-474H Recombinant Human ALDH1L1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ALDH1L1-491H Recombinant Human Aldehyde Dehydrogenase 1 Family, Member L1, His-tagged E.coli His
    Human ALDH1L1-492H Recombinant Human Aldehyde Dehydrogenase 1 Family, Member L1, GST-tagged E.coli GST
    Human ALDH1L1-5813H Recombinant Human ALDH1L1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ALDH1L1-9554H Recombinant Human ALDH1L1, His-tagged E.coli His
    Mouse ALDH1L1-1523M Recombinant Mouse ALDH1L1 Protein Mammalian Cell His
    Mouse Aldh1l1-344M Recombinant Mouse Aldh1l1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat ALDH1L1-619R Recombinant Rat ALDH1L1 Protein Mammalian Cell His
    Rhesus Macaque ALDH1L1-302R Recombinant Rhesus monkey ALDH1L1 Protein, His-tagged Mammalian Cell His
    Zebrafish ALDH1L1-7841Z Recombinant Zebrafish ALDH1L1 Mammalian Cell His

    aldh1l1 involved in several pathways and played different roles in them. We selected most pathways aldh1l1 participated on our site, such as Folate-Alcohol and Cancer Pathway, One Carbon Metabolism, One carbon pool by folate, which may be useful for your reference. Also, other proteins which involved in the same pathway with aldh1l1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Folate-Alcohol and Cancer Pathway CYP2E1; ALDH1L1
    One Carbon Metabolism FTCD; AHCY; MTFMT; MTHFD2; MTHFS; ST20-MTHFS; ALDH1L1
    One carbon pool by folate MTHFR; MTHFD1B; SHMT2; MTHFS; MTFMT; ALDH1L1; FTCD; ALDH1L2; TYMS; MTR
    folate transformations I ALDH1L1; MTHFD2; ALDH1L2; MTHFSD

    aldh1l1 has several biochemical functions, for example, aldehyde dehydrogenase (NAD) activity, catalytic activity, formyltetrahydrofolate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by aldh1l1 itself. We selected most functions aldh1l1 had, and list some proteins which have the same functions with aldh1l1. You can find most of the proteins on our site.

    Function Related Protein
    aldehyde dehydrogenase (NAD) activity ALDH6A1; ALDH3B2; Aldh1a7; ALDH3A1; ALDH3A2B; ALDH9A1; ALDH1L2; ALDH4A1; ALDH1A3; ALDH1A1
    catalytic activity ALDOCA; HHIPL1; HSD17B1; PARP3; TM9SF1; PFKFB2A; GTF2F1; ISOC2; GOT1L1; ACSL3A
    formyltetrahydrofolate dehydrogenase activity ALDH1L2; ALDH1L1
    hydroxymethyl-, formyl- and related transferase activity ALDH1L1; ALDH1L2
    methyltransferase activity SUV39H1A; FAM86C; PRMT8B; CMTR2; PRDM15; METTL17; MLL1; FTSJD1; COMTB; SETDB1B

    aldh1l1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with aldh1l1 here. Most of them are supplied by our site. Hope this information will be useful for your research of aldh1l1.


    Huang, J; Zhang, L; et al. Global Transcriptome Analysis of Peripheral Blood Identifies the Most Significantly Down-regulated Genes Associated with Metabolism Regulation in Klinefelter Syndrome. MOLECULAR REPRODUCTION AND DEVELOPMENT 82:17-25(2015).

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