Recombinant Full Length Human ALDH1L1 Protein, C-Flag-tagged

• Cat.No.: ALDH1L1-1509HFL
• Product Overview: Recombinant Full Length Human ALDH1L1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 98.6 kDa
• AA Sequence: MKIAVIGQSLFGQEVYCHLRKEGHE VVGVFTVPDKDGKADPLGLEAEKDG VPVFKYSRWRAKGQALPDVV AKYQALGAELNVLPFCSQFIPMEII SAPRHGSIIYHPSLLPRHRGASAIN WTLIHGDKKGGFSIFWADDG LDTGDLLLQKECEVLPDDTVSTLYN RFLFPEGIKGMVQAVRLIAEGKAPR LPQPEEGATYEGIQKKETAK INWDQPAEAIHNWIRGNDKVPGAWT EACEQKLTFFNSTLNTSGLVPEGDA LPIPGAHRPGVVTKAGLILF GNDDKMLLVKNIQLEDGKMILASNF FKGAASSVLELTEAELVTAEAVRSF WQRILPKVLEVEDSTDFFKS GAASVDVVRLVEEVKELCDGLELEN EDVYMASTFGDFIQLLVRKLRGHDE EGECSIDYVEMAVNKRTVRM PHQLFIGGEFVDAEGAKTSETINPT DGSVICQVSLAQVTDVDKAVAAAKD AFENGRWGKIGARDRGRLMY RLADLMEQHQEELATIEALDAGAVY TLALKTHVGMSIQTFRYFAGWCDKI QGSTIPINQARPNRNLTLTR KEPVGVCGIIIPWNYPLMMLSWKTA ACLAAGNTVVIKPAQVTPLTALKFA ELTLKAGIPKGVVNVLPGSG SLVGQRLSDHPDVRKIGFTGSTEVG KHIMKSCAISNVKKVSLELGGKSPL IIFADCDLNKAVQMGMSSVF FNKGENCIAAGRLFVEDSIHDEFVR RVVEEVRKMKVGNPLDRDTDHGPQN HHAHLVKLMEYCQHGVKEGA TLVCGGNQVPRPGFFFEPTVFTDVE DHMFIAKEESFGPVMIISRFADGDL DAVLSRANATEFGLASGVFT
  RDINKALYVSDKLQAGTVFVNTYNK TDVAAPFGGFKQSGFGKDLGEAALN EYLRVKTVTFEYTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: One carbon pool by folate

Gene Information

• Gene Name: ALDH1L1 aldehyde dehydrogenase 1 family member L1 [ Homo sapiens (human) ]
• Official Symbol: ALDH1L1
• Synonyms: FDH; FTHFD; 10-fTHF; 10-FTHFDH
• Gene ID: 10840
• mRNA Refseq: NM_012190.4
• Protein Refseq: NP_036322.2
• MIM: 600249
• UniProt ID: O75891