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Official Full Name aldehyde dehydrogenase 4 family, member A1
Background This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Synonyms ALDH4A1; aldehyde dehydrogenase 4 family, member A1; ALDH4; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; P5CDh; P5C dehydrogenase; aldehyde dehydrogenase family 4 member A1; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase; P5C
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALDH4A1-001HCL Recombinant Human ALDH4A1 cell lysate Insect Cell N/A
    Human ALDH4A1-2033H Recombinant Human ALDH4A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ALDH4A1-434HCL Recombinant Human ALDH4A1 cell lysate Insect Cell N/A
    Human ALDH4A1-449H Recombinant Human ALDH4A1 Protein, GST-tagged Wheat Germ GST
    Human ALDH4A1-472H Recombinant Human ALDH4A1 Protein, His & GST-tagged Insect Cell His/GST
    Human ALDH4A1-4755H Recombinant Human ALDH4A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ALDH4A1-499H Recombinant Human Aldehyde Dehydrogenase 4 Family, Member A1, GST-tagged E.coli GST
    Human ALDH4A1-516H Recombinant Human ALDH4A1, Gly & Pro tagged Insect Cell His
    Mouse ALDH4A1-1530M Recombinant Mouse ALDH4A1 Protein Mammalian Cell His
    Mouse Aldh4a1-1593M Recombinant Mouse Aldh4a1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Chicken ALDH4A1-4544C Recombinant Chicken ALDH4A1 Mammalian Cell His
    Zebrafish ALDH4A1-11377Z Recombinant Zebrafish ALDH4A1 Mammalian Cell His

    aldh4a1 involved in several pathways and played different roles in them. We selected most pathways aldh4a1 participated on our site, such as Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with aldh4a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alanine, aspartate and glutamate metabolism GLSA; ALDH4A1; DDO; RIMKLA; ASNS; ABAT; GLS; GPT; GPT2L; GAD1B
    Arginine and proline metabolism P4HA3; P4HA1B; PRODH; P4HA2; AZIN2; CKB; ALDH2; CKMT2B; MAOB; SAT1
    Metabolic pathways PANK4; PGAM1A; CDO1; ST6GALNAC3; PLA2G4A; ALDH9A1A.1; UGT2A3; NME2A; NDUFV1; CYP3A25

    aldh4a1 has several biochemical functions, for example, 1-pyrroline-5-carboxylate dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by aldh4a1 itself. We selected most functions aldh4a1 had, and list some proteins which have the same functions with aldh4a1. You can find most of the proteins on our site.

    Function Related Protein
    1-pyrroline-5-carboxylate dehydrogenase activity ALDH4A1
    aldehyde dehydrogenase (NAD) activity ALDH5A1; ALDH16A1; ALDH8A1; ALDH3A1; ALDH1A1; ALDH9A1A.1; ALDH2; ALDH9A1; ALDH3A2A; ALDH3B2
    electron carrier activity NQO2; NDUFV2; NDUFS2; GSR; ACADSB; ACADL; GLRX2; ACOX3; TSTA3; ACAD9
    identical protein binding COL2A1; MICU1; RASSF3; PLDN; CLDN15; COMMD1; PRDX1; LUC7L; ZNF212; BAX

    aldh4a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with aldh4a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of aldh4a1.

    ARG1; CLPP

    Wang, L; Guo, HJ; et al. Enrichment and characterization of cancer stem-like cells from a cervical cancer cell line. MOLECULAR MEDICINE REPORTS 9:2117-2123(2014).
    Ueyama, T; Yamamoto, Y; et al. Is Gastrectomy-Induced High Turnover of Bone with Hyperosteoidosis and Increase of Mineralization a Typical Osteomalacia?. PLOS ONE 8:-(2013).

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