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ALDH4A1

  • Official Full Name

    aldehyde dehydrogenase 4 family, member A1

  • Overview

    This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
  • Synonyms

    ALDH4A1; aldehyde dehydrogenase 4 family, member A1; ALDH4; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; P5CDh; P5C dehydrogenase; aldehyde dehydrogenase family 4 member A1; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase; P5C;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALDH4A1-516H Recombinant Human ALDH4A1, Gly & Pro tagged Insect Cell His
Human ALDH4A1-449H Recombinant Human ALDH4A1 Protein, GST-tagged Wheat Germ GST
Human ALDH4A1-472H Recombinant Human ALDH4A1 protein, His&GST-tagged Insect Cells His/GST Lys25-Gln563
Human ALDH4A1-499H Recombinant Human Aldehyde Dehydrogenase 4 Family, Member A1, GST-tagged E.coli GST
Human ALDH4A1-434HCL Recombinant Human ALDH4A1 cell lysate Insect Cell N/A
Human ALDH4A1-001HCL Recombinant Human ALDH4A1 cell lysate Insect Cell N/A
Human ALDH4A1-1410HF Recombinant Full Length Human ALDH4A1 Protein, GST-tagged In Vitro Cell Free System GST 563 amino acids
Human ALDH4A1-4755H Recombinant Human ALDH4A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ALDH4A1-2033H Recombinant Human ALDH4A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ALDH4A1-315H Recombinant Human ALDH4A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ALDH4A1-695HFL Recombinant Full Length Human ALDH4A1 Protein, C-Flag-tagged Mammalian cells Flag
Human ALDH4A1-2203H Recombinant Human ALDH4A1 protein Insect Cells N/A Lys25-Gln563
Human ALDH4A1-315H-B Recombinant Human ALDH4A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ALDH4A1-1530M Recombinant Mouse ALDH4A1 Protein Mammalian Cell His
Mouse Aldh4a1-1593M Recombinant Mouse Aldh4a1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ALDH4A1-457M-B Recombinant Mouse ALDH4A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ALDH4A1-457M Recombinant Mouse ALDH4A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ALDH4A1-11377Z Recombinant Zebrafish ALDH4A1 Mammalian Cell His
Chicken ALDH4A1-4544C Recombinant Chicken ALDH4A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ALDH4A1 Related Articles

ALDH4A1 involved in several pathways and played different roles in them. We selected most pathways ALDH4A1 participated on our site, such as Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH4A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alanine, aspartate and glutamate metabolismGLSA;GLUD1B;GLS2;ybaS;RIMKLA;AGXTB;FOLH1;DDO;GLUL
Arginine and proline metabolismDAO1;CARNS1;PYCR1B;CKBB;PRODH;MAOA;SMS;NOS2A;AOC1
Metabolic pathwaysALDOAA;MTMR4;PLCH1;CYP11B1;ATP6V0CA;POLR2J3;SQLEA;PPCDC;RRM2

ALDH4A1 has several biochemical functions, for example, 1-pyrroline-5-carboxylate dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH4A1 itself. We selected most functions ALDH4A1 had, and list some proteins which have the same functions with ALDH4A1. You can find most of the proteins on our site.

Function Related Protein
1-pyrroline-5-carboxylate dehydrogenase activity
aldehyde dehydrogenase (NAD) activityALDH8A1;ALDH1B1;ALDH1L1;ALDH3A2;ALDH2;ALDH1A3;ALDH9A1;ALDH3A2B;ALDH5A1
electron carrier activitySDHD;AKR1B1;ACOX1;GCDHA;GSR;GRXCR1;NDUFS1;HSD17B6;AKR1A1
identical protein bindingKLHL7;CALHM1;PCBD1;LDHA;SCAND1;SOD2;SH3GLB1;PNMA5;PRPF19

ALDH4A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH4A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH4A1.

ARG1; CLPP

Wang, L; Guo, HJ; et al. Enrichment and characterization of cancer stem-like cells from a cervical cancer cell line. MOLECULAR MEDICINE REPORTS 9:2117-2123(2014).
Ueyama, T; Yamamoto, Y; et al. Is Gastrectomy-Induced High Turnover of Bone with Hyperosteoidosis and Increase of Mineralization a Typical Osteomalacia?. PLOS ONE 8:-(2013).
  • Q&As
  • Reviews

Q&As (14)

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Can variations in the ALDH4A1 gene affect an individual's response to certain medications? 01/17/2023

The impact of ALDH4A1 gene variations on an individual's response to medications has not been extensively studied. However, since ALDH4A1 is involved in proline metabolism, it is possible that certain variations in this gene may influence the metabolism or efficacy of medications that are metabolized by proline-related pathways. Further research is needed to explore this potential association.

Are there any diseases associated with mutations in the ALDH4A1 gene? 08/09/2022

Mutations in the ALDH4A1 gene can cause a rare autosomal recessive disorder called hyperprolinemia type II or pyrroline-5-carboxylate reductase 1 deficiency. This condition is characterized by elevated levels of proline and P5C in the body, and it may lead to intellectual disability, developmental delay, seizures, and other neurological symptoms.

Are there any known drugs or therapies that target ALDH4A1? 08/07/2022

Currently, there are no specific drugs or therapies that directly target ALDH4A1. However, ALDH inhibitors, such as disulfiram, have been investigated for their potential to inhibit multiple ALDH enzymes, including ALDH4A1. These inhibitors have shown promise in preclinical studies for various diseases, including cancer and neurodegenerative disorders. Further research is necessary to explore the therapeutic potential of targeting ALDH4A1 specifically.

Can variations in the ALDH4A1 gene affect an individual's susceptibility to certain diseases? 02/15/2022

There is limited research on the impact of ALDH4A1 gene variations on disease susceptibility. However, a few studies have suggested that certain variations in the ALDH4A1 gene may be associated with an increased risk of developing Alzheimer's disease and schizophrenia. Further research is needed to confirm these findings and understand the underlying mechanisms.

Are there any ongoing clinical trials investigating the role of ALDH4A1 in disease? 09/12/2021

As of now, there is limited information on ongoing clinical trials specifically investigating ALDH4A1. However, there may be studies related to ALDH enzymes or metabolic pathways that indirectly involve ALDH4A1. It is recommended to search clinical trial databases or consult with healthcare professionals for the most up-to-date information on ongoing research related to ALDH4A1 and its potential implications in disease.

Is ALDH4A1 involved in any other metabolic pathways or biological processes? 09/09/2021

Apart from its role in proline catabolism, ALDH4A1 has been found to interact with other proteins and participate in various metabolic pathways. It is involved in the synthesis of polyamines, which are important for cell growth and proliferation. Additionally, ALDH4A1 has been associated with the regulation of reactive oxygen species (ROS) levels in cells, suggesting a potential role in oxidative stress response.

How is ALDH4A1 protein related to collagen production? 08/14/2020

While the direct link between ALDH4A1 and collagen production is not well-established, there is some evidence suggesting an indirect connection. Proline, which is produced through the action of ALDH4A1, is an essential amino acid required for collagen synthesis. Therefore, disturbances in proline metabolism, such as in ALDH4A1 deficiency, may potentially impact collagen production and affect connective tissues' integrity.

How is ALDH4A1 protein regulated in the body? 02/11/2020

The regulation of ALDH4A1 protein levels and activity is not fully understood. However, studies suggest that its expression can be influenced by various factors, including cellular stress, oxidative conditions, and transcriptional regulation. For example, studies have shown that the ALDH4A1 gene can be upregulated under conditions of oxidative stress. Further research is needed to elucidate the precise mechanisms involved in the regulation of ALDH4A1 in the body.

Is the ALDH4A1 protein expressed in specific tissues or organs? 10/18/2019

Yes, the ALDH4A1 protein is expressed in various tissues and organs. It is known to be present in high levels in the liver, kidney, and brain. It is also found in lower amounts in other tissues such as muscle, heart, and lung.

Is ALDH4A1 protein involved in cancer development or progression? 09/21/2019

The role of ALDH4A1 in cancer is not well-studied, and its involvement in cancer development or progression is not clearly understood. However, there is some emerging evidence suggesting a potential link between ALDH4A1 and certain forms of cancer, such as breast cancer and lung adenocarcinoma. Future research is needed to further investigate the significance of ALDH4A1 in cancer biology.

Are there any known genetic disorders that result from ALDH4A1 deficiency? 06/13/2018

Yes, ALDH4A1 deficiency, also known as pyrroline-5-carboxylate dehydrogenase deficiency, is a rare genetic disorder caused by mutations in the ALDH4A1 gene. This condition leads to impaired proline metabolism and elevated levels of P5C and proline in the body. ALDH4A1 deficiency can result in a range of neurological symptoms, including developmental delay, seizures, intellectual disability, and behavioral abnormalities.

Are there any drugs or compounds known to modulate the expression or activity of ALDH4A1? 08/26/2016

Currently, there are no known drugs or compounds specifically targeted towards modulating the expression or activity of ALDH4A1. However, research in this area is ongoing, and future studies may shed light on potential therapeutics that can influence the activity of this enzyme.

Is there a link between ALDH4A1 and alcohol metabolism? 08/25/2016

ALDH4A1 is not directly involved in alcohol metabolism. Alcohol metabolism primarily involves the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) enzymes. ALDH4A1 is part of a different metabolic pathway involved in proline breakdown, and its function is unrelated to alcohol metabolism.

Can the activity of the ALDH4A1 protein be regulated? 07/08/2016

The activity of the ALDH4A1 protein can be regulated through several mechanisms. One such mechanism involves the feedback inhibition by its product, glutamate. Elevated levels of glutamate can inhibit ALDH4A1 activity to prevent unnecessary production of glutamate. Additionally, post-translational modifications or the presence of specific co-factors may also impact the activity of ALDH4A1.

Customer Reviews (3)

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Reviews
07/16/2020

    Its versatility allows for exploring its various roles and functions, shedding light on its significance in crucial biochemical pathways and cellular processes.

    04/07/2019

      By incorporating the ALDH4A1 Protein into their studies, scientists have the opportunity to conduct their research with utmost confidence, paving the way for groundbreaking discoveries and novel insights in their respective fields.

      04/11/2018

        Considering the aforementioned qualities, I wholeheartedly recommend the ALDH4A1 Protein to fellow researchers in search of a top-tier protein solution that not only meets their experimental needs but also benefits from exceptional technical support.

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