ALG12
-
Official Full Name
asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae)
-
Overview
This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the;eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor;(dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with;congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation.
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ALG12-9572H | Recombinant Human ALG12, GST-tagged | E.coli | GST | 375-488a.a. | |
Human | ALG12-461H | Recombinant Human ALG12 Protein, GST-tagged | Wheat Germ | GST | ||
Zebrafish | ALG12-5710Z | Recombinant Zebrafish ALG12 | Mammalian Cell | His | ||
Chicken | ALG12-3334C | Recombinant Chicken ALG12 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ALG12 involved in several pathways and played different roles in them. We selected most pathways ALG12 participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
N-Glycan biosynthesis | ALG10;MAN2A1;RPN2;MGAT3;MGAT5B;ALG1;MGAT2;DPM2;MGAT4C |
Metabolic pathways | PAFAH1B1B;HSD17B10;MAOB;CEL.1;MBOAT2B;PIGC;CYP2P6;CYP3A5;DSE |
ALG12 has several biochemical functions, for example, alpha-1,6-mannosyltransferase activity, dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity, mannosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG12 itself. We selected most functions ALG12 had, and list some proteins which have the same functions with ALG12. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
alpha-1,6-mannosyltransferase activity | POC1BL;4931440L10Rik;GTDC2;GALNTL4;B3GNT9-PS;B3GNT8;B3GNTL1;POMGNT2;GLT8D1 |
dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity | |
mannosyltransferase activity | PIGZ;DPY19L4;GALNT18A;PIGB;UGGT1;B3GNT9-PS;POMGNT2;PIGV;DPY19L1L |
ALG12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG12.
RPL13A; PRDX4
- Q&As
- Reviews
Q&As (18)
Ask a questionALG12 defects have not yet been fully explained by research on how they affect cell signaling mechanisms.
The relationship between ALG12 gene polymorphism and other genetic or environmental factors is still insufficient, and the existing results are not enough to make a full proof.
This protein mutations can lead to the failure of the synthesis of polysaccharides and glycoproteins, leading to diseases such as glycogen disease. Its clinical characteristics need to be evaluated through clinical studies.
ALG12's reading frame specifies an annotated sequence of organic molecules, branching point reactions in the process of breaking down sugars and lipids.
The protein encoded by ALG12 is involved in the reactants of the transfer chemical reaction, enabling the successful formation of polysaccharides and glycoproteins. Its functional characteristics are related to glycosyl synthesis in other glycogen organisms.
ALG12 is expressed in different tissues in different amounts, such as in fat, liver, gastrointestinal tract and muscle.
ALG12 is involved in the catalysis of glycosylation process, which may affect the interaction of fatty acid and glucose metabolism, but more studies are needed to clarify.
The mechanism and signaling pathway of ALG12 gene regulation are similar to other glycosylation genes, but the specific situation remains to be studied.
The mutations may cause a variety of neurological diseases and require further research using relevant animal models and nervous system cell lines.
The post-transcriptional modification and expression pattern of ALG12 gene have not been studied deeply enough, and further research is needed.
This can be used as a branch enzyme of NSDHL, if it produces an anthraquinone derivative with progesterone, and increases the amount of activated enzyme by reversing the reaction; It can also be treated with hyperliquefied P-body enzymes.
At present, a large number of studies have been carried out on the correlation between gene mutation and ALG12 gene and diseases, and many diseases have been confirmed to be associated with ALG12 gene mutation, but these scientific research results need more verification and analysis.
ALG12 mutations may affect lipid metabolism and enzyme activity, and there are some studies and confirmations, and further studies are needed to determine the specific mechanisms.
Although ALG12 has a regulatory role in lipid and glycogen processing, its detailed mechanism of action needs to be further investigated in cell and animal models.
The ALG12 genome structure is composed of multiple exons, which need to be processed into unique mRNA after transcription, and then function through regulation by various regulatory mechanisms.
Until now, there have been few studies on the effect of ALG12 mutation on hypoxia tolerance.
ALG12 encodes proteins that extend chains by transferring acid groups through molecules in glycosylation catalyzed by proteins such as lactase and glycoprotein processing enzymes.
ALG12 mutations may be associated with disorders of lipid metabolism and neurological disorders.
Customer Reviews (4)
Write a reviewAn important metabolic enzyme in the pathway of polysaccharide metabolism and pentose metabolism.
It can be used as a biomarker to prevent disease.
Strong operability in the experiment.
Activity is specific.
Ask a Question for All ALG12 Products
Required fields are marked with *
My Review for All ALG12 Products
Required fields are marked with *