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Official Full Name asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)
Background This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants.
Synonyms ALG2; asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae); asparagine linked glycosylation 2 homolog (yeast, alpha 1,3 mannosyltransferase); alpha-1,3/1,6-mannosyltransferase ALG2; CDGIi; FLJ14511; hALPG2; NET38; OTTHUMP00000123474; 3-mannosyltransferase ALG2; ALG2_HUMAN; Alpha 1,3 mannosyltransferase ALG2; Alpha-1; Asparagine linked glycosylation protein 2; Asparagine-linked glycosylation protein 2 homolog; GDP Man:Man(1)GlcNAc(2) PP dolichol mannosyltransferase; GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase; OTTHUMP00000021785; RP11-13B9.1; homolog of yeast ALG2; alpha-1,3-mannosyltransferase ALG2; GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALG2-463H Recombinant Human ALG2 Protein, GST-tagged Wheat Germ GST
    Human ALG2-6198H Recombinant Human ALG2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ALG2-8906HCL Recombinant Human ALG2 293 Cell Lysate HEK293 N/A
    Human ALG2-9575H Recombinant Human ALG2, His-tagged E.coli His
    Mouse ALG2-1546M Recombinant Mouse ALG2 Protein Mammalian Cell His
    Mouse Alg2-1598M Recombinant Mouse Alg2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque ALG2-303R Recombinant Rhesus monkey ALG2 Protein, His-tagged Mammalian Cell His
    Zebrafish ALG2-5978Z Recombinant Zebrafish ALG2 Mammalian Cell His

    alg2 involved in several pathways and played different roles in them. We selected most pathways alg2 participated on our site, such as Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with alg2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Asparagine N-linked glycosylation GORASP1; NEU4; CTAGE5; SERPINA1L; BET1; ST8SIA3; CTSC; OS9; TRAPPC10; NANP
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein ZNF408; ST3GAL3A; ST6GAL2B; ST8SIA3; ALG10B; MPDU1B; ST8SIA2; GNE; NEU3; SLC35A1
    Metabolic pathways LASS5; PNLIP; POLR3F; ENO3; RRM2B; FUT9; H2-KE6; DGKAA; PSAT1; MTHFD2
    Metabolism of proteins CPE; FBXW4; FBXW5; YKT6; APEH; NANP; LMCD1; GNE; IGFBP5A; GRPEL2
    N-Glycan biosynthesis RABGNT1; MGAT5B; ALG10; ALG6; ALG3; MGAT1A; ALG2; MGAT3; ZNF408; DPM1
    Post-translational protein modification ADAMTS20; SPON1B; DOHH; PPP6R3; PPP6C; B3GNT8; CNIH3; A4GNT; SPON1A; RNF2

    alg2 has several biochemical functions, for example, GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity, alpha-1,3-mannosyltransferase activity, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by alg2 itself. We selected most functions alg2 had, and list some proteins which have the same functions with alg2. You can find most of the proteins on our site.

    Function Related Protein
    GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity ALG2
    alpha-1,3-mannosyltransferase activity GALNT18A; ALG8; 4931440L10Rik; UGGT1; GTDC2; B3GNTL1; POMGNT2; ALG3; POC1BL; DPY19L4
    calcium-dependent protein binding MBL2; S100A11; ANXA2; VAMP2; ANXA11; DMBT1; C9orf9; VPS37C; CASQ2; RAC3
    protein N-terminus binding UNC13A; SDCBP; TBL1XR1; MECP2; FEZ1; SMARCE1; YWHAQ; TARBP2; MAP2K1; CSNK2A2
    protein binding C1orf38; NABP1; TEN1; TNFSF12; PEBP1; TTR; KIAA1217; MAGEA11; CRYBA2; SYMPK
    protein heterodimerization activity TGFB2; BIK; NKX2-5; SYCP2; HIST1H47; XBP1; SMC1A; HYPM; GABRR1; NFE2L2A

    alg2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with alg2 here. Most of them are supplied by our site. Hope this information will be useful for your research of alg2.

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