ALG6
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Official Full Name
asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
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Overview
This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. -
Synonyms
ALG6; asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae); asparagine linked glycosylation 6 homolog (yeast, alpha 1,3 glucosyltransferase); dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; E230028F23Rik; Asparagine linked glycosylation 6; Asparagine linked glycosylation 6 homolog (S. cerevisiae alpha 1 3 glucosyltransferase); Asparagine linked glycosylation 6 homolog; Dolichyl P Glc:Man9GlcNAc2 PP dolichyl glucosyltransferase; Dolichyl P Glc:Man9GlcNAc2 PP dolichylglucosyltransferase; Dolichyl pyrophosphate Man9GlcNAc2 alpha 1 3 glucosyltransferase; Man(9)GlcNAc(2) PP Dol alpha 1 3 glucosyltransferase; MGC124652; My 046; My046; OTTMUSP00000008309; RP23-35D18.4; asparagine-linked glycosylation protein 6 homolog; Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; dolichyl-P-Glc:Man9GlcNAc2-PP-dolichylglucosyltransferase; dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase; dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3-glucosyltransferase); asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase); CDG1C;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ALG6-466H | Recombinant Human ALG6 Protein, GST-tagged | Wheat Germ | GST |
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| Mouse | ALG6-1549M | Recombinant Mouse ALG6 Protein | Mammalian Cell | His |
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| Mouse | ALG6-469M-B | Recombinant Mouse ALG6 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | ALG6-469M | Recombinant Mouse ALG6 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | ALG6-630R | Recombinant Rat ALG6 Protein | Mammalian Cell | His |
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| Rat | ALG6-286R | Recombinant Rat ALG6 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | ALG6-286R-B | Recombinant Rat ALG6 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | ALG6-1117Z | Recombinant Zebrafish ALG6 | Mammalian Cell | His |
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| Chicken | ALG6-6005C | Recombinant Chicken ALG6 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
ALG6 involved in several pathways and played different roles in them. We selected most pathways ALG6 participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| N-Glycan biosynthesis | B4GALT2;MAN1C1;DPM1;MGAT3;MAN1A1;DAD1;ALG1;RPN1;ALG14 |
| Metabolic pathways | COX7B;ybaS;RFK;TST;NAT8L;PTGIS;ST6GALNAC5;POLA2;NME5 |
ALG6 has several biochemical functions, for example, dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity, glucosyltransferase activity, transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG6 itself. We selected most functions ALG6 had, and list some proteins which have the same functions with ALG6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity | ALG6;GLT8D1;B3GNT9-PS;POC1BL;PIGB;B3GNT8;DPY19L1;GALNT18A;POMGNT2 |
| glucosyltransferase activity | KDELC1;KDELC2;DPY19L1;POGLUT1;UGGT1;GALNTL4;PIGB;B3GNT8;POC1BL |
| transferase activity | B3GNT8;EPHB4B;ELOVL1A;METTL7B;ACVR1BA;PDK2B;NT5C3A;GSTM7;POLE2 |
| transferase activity, transferring glycosyl groups | UGT2A4;EXT2;POC1BL;ST3GAL5L;4931440L10Rik;C1GALT1A;FUT9B;UGT2A6;UGT5C2 |
| transferase activity, transferring hexosyl groups | UGT5G2;GBGT1;UGT1A2;UGT5D1;UGT5C2;PIGM;A3GALT2;GGTA1;UGT1B5 |
ALG6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG6.
- Q&As
- Reviews
Q&As (16)
Ask a questionNo studies have confirmed whether ALG6 is involved in mitochondrial glucose metabolism, and more studies are needed to prove it.
Overexpression or knockout of ALG6 can negatively affect cellular glycosylation and the stability of ER and Golgi bodies, but the specific effects need to be further explored.
It is mainly distributed in the endoplasmic reticulum (ER) and the Golgi apparatus.
ALG6 mutation may lead to the occurrence and development of some metabolic diseases such as CDG, and further investigation is needed to confirm its role in metabolic diseases.
ALG6 is involved in several biological processes including protein glycosylation, ER and Golgi body sugar metabolism.
ALG6 plays an important role in protein glycosylation pathway, participating in the synthesis and modification of sugar chains.
ALG6 plays an important role in some neurological diseases, such as central nervous system dysplasia, leading to symptoms such as mental retardation.
At present, there is no direct evidence that ALG6 is related to the occurrence and development of cancer, but glycosylation plays an important role in metabolism and disease development, so it may be relevant to related diseases.
The regulates the expression of glycosylase and the balance of glycosylation reaction by interacting with other glycosylated enzymes such as ALG5 and ALG3.
A number of inhibitors have been developed that target ALG6 and inhibit its glycosylation activity, thereby interfering with its function in cellular processes.
ALG6 interacts with members of the glycosylase family, such as ALG5 and ALG3, and other related proteins to jointly regulate the glycosylation process of proteins.
Although there are currently no studies demonstrating the function of ALG6 in non-cellular autophagy pathways, there are indications that it may be involved in the TCA cycle and gluconeogenic pathways.
ALG6 mutations can have adverse effects on embryonic development and may therefore be associated with a number of fetal diseases.
ALG6 gene contains 14 exons, and its expression is influenced by multiple regulatory elements and signaling pathways.
ALG6 selectively catalyzes the synthesis and modification of sugar chains and plays an important role in the binding selectivity of glycosylase family members to substrate proteins.
This is mainly distributed in the endoplasmic reticulum and Golgi apparatus in mammalian cells.
Customer Reviews (4)
Write a reviewCan increase yield and purity and improve production efficiency in biotechnology production.
ALG6 has therapeutic effects on specific disease models and is promising as a new drug candidate.
Laboratory personnel feedback ALG6 is easy to operate, can meet the experimental needs, and has a good cost performance.
Have good fluorescence labeling performance in light microscopy techniques, which is helpful for cell imaging studies.
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