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Recombinant Human ALG6 Protein, GST-tagged

Cat.No. : ALG6-466H
Product Overview : Human ALG6 partial ORF ( NP_037471, 25 a.a. - 114 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 35.64 kDa
AA Sequence : SYSGAGKPPMFGDYEAQRHWQEITF NLPVKQWYFNSSDNNLQYWGLDYPP LTAYHSLLCAYVAKFINPDWIALHT SRGYESQAHKLFMRT
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ALG6 asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae) [ Homo sapiens ]
Official Symbol : ALG6
Synonyms : ALG6; asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae); asparagine linked glycosylation 6 homolog (yeast, alpha 1,3 glucosyltransferase); dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; asparagine-linked glycosylation protein 6 homolog; Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; dolichyl-P-Glc:Man9GlcNAc2-PP-dolichylglucosyltransferase; dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase; dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3-glucosyltransferase); asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase); CDG1C;
Gene ID : 29929
mRNA Refseq : NM_013339
Protein Refseq : NP_037471
MIM : 604566
UniProt ID : Q9Y672

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (16)

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Does ALG6 participate in mitochondrial glucose metabolism? 09/30/2022

No studies have confirmed whether ALG6 is involved in mitochondrial glucose metabolism, and more studies are needed to prove it.

What effect does overexpression or knockout of ALG6 have on cells? 09/08/2022

Overexpression or knockout of ALG6 can negatively affect cellular glycosylation and the stability of ER and Golgi bodies, but the specific effects need to be further explored.

What is the place of ALG6 in cellular processes? 03/25/2022

It is mainly distributed in the endoplasmic reticulum (ER) and the Golgi apparatus.

In what metabolic diseases does ALG6 play a role? 01/25/2022

ALG6 mutation may lead to the occurrence and development of some metabolic diseases such as CDG, and further investigation is needed to confirm its role in metabolic diseases.

What biological processes does ALG6 participate in? 11/21/2021

ALG6 is involved in several biological processes including protein glycosylation, ER and Golgi body sugar metabolism.

What are the molecular biological characteristics of ALG6? 08/22/2021

ALG6 plays an important role in protein glycosylation pathway, participating in the synthesis and modification of sugar chains.

In what neurological diseases does ALG6 play a role? 04/20/2021

ALG6 plays an important role in some neurological diseases, such as central nervous system dysplasia, leading to symptoms such as mental retardation.

In which cancers does ALG6 play a role? 03/07/2021

At present, there is no direct evidence that ALG6 is related to the occurrence and development of cancer, but glycosylation plays an important role in metabolism and disease development, so it may be relevant to related diseases.

Which cell signaling molecules are involved in ALG6? 03/06/2021

The regulates the expression of glycosylase and the balance of glycosylation reaction by interacting with other glycosylated enzymes such as ALG5 and ALG3.

What are the effects of ALG6 inhibitors? 10/08/2020

A number of inhibitors have been developed that target ALG6 and inhibit its glycosylation activity, thereby interfering with its function in cellular processes.

What are the interacting proteins of ALG6? 07/09/2020

ALG6 interacts with members of the glycosylase family, such as ALG5 and ALG3, and other related proteins to jointly regulate the glycosylation process of proteins.

What non-cellular autophagy pathways are involved in ALG6? 05/18/2020

Although there are currently no studies demonstrating the function of ALG6 in non-cellular autophagy pathways, there are indications that it may be involved in the TCA cycle and gluconeogenic pathways.

Does ALG6 mutation have an adverse effect on embryonic development? 05/16/2020

ALG6 mutations can have adverse effects on embryonic development and may therefore be associated with a number of fetal diseases.

What is the gene structure and regulation of ALG6? 08/05/2019

ALG6 gene contains 14 exons, and its expression is influenced by multiple regulatory elements and signaling pathways.

Does the sugar chain selectivity of ALG6? 06/18/2019

ALG6 selectively catalyzes the synthesis and modification of sugar chains and plays an important role in the binding selectivity of glycosylase family members to substrate proteins.

How is ALG6 distributed in mammalian cells? 06/13/2019

This is mainly distributed in the endoplasmic reticulum and Golgi apparatus in mammalian cells.

Customer Reviews (4)

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Reviews
06/17/2022

    Can increase yield and purity and improve production efficiency in biotechnology production.

    04/27/2022

      ALG6 has therapeutic effects on specific disease models and is promising as a new drug candidate.

      04/05/2022

        Laboratory personnel feedback ALG6 is easy to operate, can meet the experimental needs, and has a good cost performance.

        01/05/2019

          Have good fluorescence labeling performance in light microscopy techniques, which is helpful for cell imaging studies.

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