ALKBH2
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Official Full Name
alkB, alkylation repair homolog 2 (E. coli) -
Overview
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 -
Synonyms
ALKBH2;alkB, alkylation repair homolog 2 (E. coli);alpha-ketoglutarate-dependent dioxygenase alkB homolog 2;ABH2;MGC90512;2OG Fe(II) oxy DC1;9530023G02;ABH 2;alkB alkylation repair homolog 2;ALKB2_HUMAN;ALKBH2 alkB;Alkylated DNA repair protein alkB homolog;Alkylated DNA repair protein alkB homolog 2;Alkylation repair homolog 2;Alpha ketoglutarate dependent dioxygenase alkB homolog 2;AU016977;EC 1.14.11.;FLJ99103;hABH2;mABH2;Oxy DC1;2OG-Fe(II) oxy DC1;OTTHUMP00000240521;OTTHUMP00000240522
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
ALKBH2 involved in several pathways and played different roles in them. We selected most pathways ALKBH2 participated on our site, such as ALKBH2 mediated reversal of alkylation damage,DNA Damage Reversal,DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Reversal of alkylation damage by DNA dioxygenases | ASCC2,ALKBH3,ASCC3,ASCC1 |
| DNA Repair | COPS7B,CETN2,TP53BP1,RAD9,RNF168,TDP2B,RNF4,UBE2L6,ASCC2,TOPBP1 |
| DNA Damage Reversal | MGMT,ALKBH3,ASCC2,ASCC3,ASCC1 |
Protein Function
ALKBH2 has several biochemical functions, for example, DNA-N1-methyladenine dioxygenase activity,cytosine C-5 DNA demethylase activity,ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH2 itself. We selected most functions ALKBH2 had, and list some proteins which have the same functions with ALKBH2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ferrous iron binding | PLOD1,FECH,ALKBH3,HEPH,FTO,DNAJC24,TH,TET2,ISCA2,Trf |
| DNA-N1-methyladenine dioxygenase activity | ALKBH3,PHF2,JMJD1C,KDM5BB,FTO,KDM5D |
| cytosine C-5 DNA demethylase activity | ALKBH3 |
Interacting Protein
ALKBH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH2.
ssdna_dadts;Nedd1;Sesn2;FERMT3;SLX4;Kif19
Resources
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References
- Wang, GQ; He, QZ; et al. The Atomic Resolution Structure of Human AlkB Homolog 7 (ALKBH7), a Key Protein for Programmed Necrosis and Fat Metabolism. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27924-27936(2014).
- Korvald, H; Falnes, PO; et al. The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity. DNA REPAIR 11:453-462(2012).
