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Recombinant Human ALKBH2 Protein, GST-tagged

Cat.No. : ALKBH2-475H
Product Overview : Human ALKBH2 full-length ORF ( NP_001001655.1, 1 a.a. - 261 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 55.7 kDa
AA Sequence : MDRFLVKGAQGGLLRKQEEQEPTGE EPAVLGGDKESTRKRPRREAPGNGG HSAGPSWRHIRAEGLDCSYTVLFGK AEADEIFQELEKEVEYFTGALARVQ VFGKWHSVPRKQATYGDAGLTYTFS GLTLSPKPWIPVLERIRDHVSGVTG QTFNFVLINRYKDGCDHIGEHRDDE RELAPGSPIASVSFGACRDFVFRHK DSRGKSPSRRVAVVRLPLAHGSLLM MNHPTNTHWYHSLPVRKKVLAPRVN LTFRKILLTKK
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ALKBH2 alkB, alkylation repair homolog 2 (E. coli) [ Homo sapiens ]
Official Symbol : ALKBH2
Synonyms : ALKBH2; alkB, alkylation repair homolog 2 (E. coli); alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; ABH2; MGC90512; oxy DC1; 2OG-Fe(II) oxy DC1; alkylated DNA repair protein alkB homolog 2; FLJ99103;
Gene ID : 121642
mRNA Refseq : NM_001001655
Protein Refseq : NP_001001655
MIM : 610602
UniProt ID : Q6NS38

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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Is the functional regulation of ALKBH2 affected by epigenetic changes? 04/20/2023

The functional regulation of ALKBH2 may be affected by epigenetic changes, such as histone modification and DNA methylation.

Does ALKBH2 mutation have adverse effects on embryonic development? 01/26/2023

Mutations in ALKBH2 may affect the development of embryos and lead to related diseases.

What are the molecular biological characteristics of ALKBH2? 11/11/2022

ALKBH2 is involved in biological processes such as double-stranded DNA repair and cell cycle control.

What metabolic pathways is ALKBH2 involved in? 08/04/2022

ALKBH2 plays an important role in the DNA demethylation pathway and is involved in a number of DNA repair related pathways.

Which DNA repair related proteins is ALKBH2 associated with? 07/11/2022

ALKBH2 interacts with a series of DNA repair related proteins such as DNA methyltransferase and DNA repair activator to participate in DNA repair.

What is the gene structure and regulation mode of ALKBH2? 06/28/2022

ALKBH2 gene contains 10 exons and its expression is influenced by several regulatory elements and signaling pathways.

Is ALKBH2 associated with certain chemicals? 04/09/2022

The activity of ALKBH2 may be regulated and interfered with by some chemicals, but the specific mechanism of action needs further study.

Can ALKBH2 modify RNA? 03/18/2022

It is mainly used to modify DNA, but it also has some ability to modify RNA.

What effect does overexpression or knockout of ALKBH2 have on cells? 02/16/2022

Overexpression or knockout of ALKBH2 can lead to incomplete repair of DNA damage and affect cell proliferation and division.

What is the position of ALKBH2 in cellular processes? 01/18/2022

ALKBH2 is mainly found in the nucleus and is involved in biological processes such as DNA repair.

What is the action mechanism of ALKBH2? 12/29/2021

ALKBH2 removes methyl groups from DNA bases and is involved in DNA repair and cell proliferation.

In which tumors does ALKBH2 act? 09/12/2021

This protein plays an important role in a variety of tumors, such as colorectal cancer, small cell lung cancer and so on.

What are the effects of ALKBH2 inhibitors? 02/22/2021

A number of inhibitors have been developed that target ALKBH2 and inhibit its ability to acquire DNA methylation repair.

Does ALKBH2 participate in the photodamage repair pathway? 12/29/2020

It is involved in multiple DNA single and double strand damage repair pathways, including light damage repair pathways.

Does ALKBH2 regulate gene transcription? 08/31/2020

Current research data show that ALKBH2 is associated with gene transcription, but the specific mechanism of action remains to be explored.

Which diseases do mutations in ALKBH2 cause? 05/26/2020

Mutations in ALKBH2 have been linked to some DNA repair related diseases and cancers.

In what neurological diseases does ALKBH2 play a role? 02/11/2020

It plays an important role in several neurological diseases, such as neurodegenerative diseases and Parkinson's disease.

What biological processes does ALKBH2 participate in? 09/27/2019

ALKBH2 is involved in biological processes such as DNA repair, cell proliferation and differentiation.

Customer Reviews (5)

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Reviews
02/13/2023

    Exhibited the expected biological activities, such as enzymatic activity and receptor binding activity.

    01/04/2022

      ALKBH2 is highly expressed and can efficiently synthesize a large number of target proteins in host cells.

      11/18/2019

        Good crystallization properties when analyzed by X-ray crystallography or other crystallization techniques.

        08/18/2019

          The products are reliable and stable, and are widely used in scientific research, industrial production and medical fields.

          06/27/2019

            The purity of ALKBH2 was good and the results obtained after analysis by SDS-PAGE or Western blot were excellent.

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