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ALKBH3

  • Official Full Name

    alkB, alkylation repair homolog 3 (E. coli)

  • Overview

    The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA;lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the;removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 (PubMed 12486230)).
  • Synonyms

    ALKBH3; alkB, alkylation repair homolog 3 (E. coli); alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; DEPC 1; prostate cancer antigen 1; prostate cancer antigen-1; alkylated DNA repair protein alkB homolog 3; ABH3; PCA1; DEPC1; DEPC-1; FLJ43614; MGC118790; MGC118792; MGC118793;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALKBH3-970H Recombinant Human Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3, His-tagged E.coli His
Human ALKBH3-9584H Recombinant Human ALKBH3, GST-tagged E.coli GST C-term-139a.a.
Human ALKBH3-26501TH Recombinant Human ALKBH3, His-tagged E.coli His 286 amino acids
Human ALKBH3-2538H Recombinant Human ALKBH3 Protein, GST-tagged Wheat Germ GST
Human ALKBH3-8901HCL Recombinant Human ALKBH3 293 Cell Lysate HEK293 N/A
Human ALKBH3-5816H Recombinant Human ALKBH3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ALKBH3-2544H Recombinant Human ALKBH3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ALKBH3-2470HF Recombinant Full Length Human ALKBH3 Protein, GST-tagged In Vitro Cell Free System GST 139 amino acids
Human ALKBH3-4707H Recombinant Human ALKBH3 protein, His-SUMO-tagged E.coli His-SUMO 1-170aa
Human ALKBH3-320H-B Recombinant Human ALKBH3 Protein Pre-coupled Magnetic Beads HEK293
Human ALKBH3-320H Recombinant Human ALKBH3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ALKBH3-231HFL Recombinant Full Length Human ALKBH3 Protein, C-Flag-tagged Mammalian cells Flag
Mouse ALKBH3-1555M Recombinant Mouse ALKBH3 Protein Mammalian Cell His
Mouse ALKBH3-475M-B Recombinant Mouse ALKBH3 Protein Pre-coupled Magnetic Beads HEK293
Mouse ALKBH3-475M Recombinant Mouse ALKBH3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ALKBH3-631R Recombinant Rat ALKBH3 Protein Mammalian Cell His
Rat ALKBH3-287R Recombinant Rat ALKBH3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ALKBH3-287R-B Recombinant Rat ALKBH3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ALKBH3-306R Recombinant Rhesus monkey ALKBH3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ALKBH3-134R-B Recombinant Rhesus Macaque ALKBH3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ALKBH3-134R Recombinant Rhesus Macaque ALKBH3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ALKBH3-952Z Recombinant Zebrafish ALKBH3 Mammalian Cell His
Chicken ALKBH3-5459C Recombinant Chicken ALKBH3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ALKBH3 Related Articles

ALKBH3 involved in several pathways and played different roles in them. We selected most pathways ALKBH3 participated on our site, such as ALKBH3 mediated reversal of alkylation damage, DNA Damage Reversal, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ALKBH3 mediated reversal of alkylation damageALKBH3;ASCC3;ASCC1;ASCC2
DNA Damage ReversalASCC2;ASCC1;ALKBH3;MGMT;ALKBH2;ASCC3
DNA RepairINO80B;PIAS3;RAD1;KIAA0101;CLSPN;RBBP8;UIMC1;TOPBP1;UBE2L6
Reversal of alkylation damage by DNA dioxygenasesASCC3;ASCC1;ASCC2;ALKBH2;ALKBH3

ALKBH3 has several biochemical functions, for example, DNA-N1-methyladenine dioxygenase activity, L-ascorbic acid binding, cytosine C-5 DNA demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH3 itself. We selected most functions ALKBH3 had, and list some proteins which have the same functions with ALKBH3. You can find most of the proteins on our site.

Function Related Protein
DNA-N1-methyladenine dioxygenase activityKDM5D;ALKBH3;ALKBH2;JMJD1C;KDM5BB;PHF2;FTO
L-ascorbic acid bindingDBH;P4HA1;PLOD3;LEPREL1;PHYH;LEPREL2;EGLN1B;ALKBH3;P4HTM
cytosine C-5 DNA demethylase activityALKBH2;ALKBH3
ferrous iron bindingTH;ISCUB;PLOD1;TRR1;TF;ISCU;ALKBH3;ALKBH2;ISCA2
protein bindingACTR6;C6;RAB3B;GOSR2;USP49;HDC;RNF10;TEF;NUP35

ALKBH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH3.

GLRX3; GOLGA2; IKZF1; LNX1; AK8; SRPK2; SRPK1

Vagbo, CB; Svaasand, EK; et al. Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response. DNA REPAIR 12:188-195(2013).
Meza, TJ; Moen, MN; et al. The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. NUCLEIC ACIDS RESEARCH 40:6620-6631(2012).
  • Q&As
  • Reviews

Q&As (17)

Ask a question
What diseases is the mutation of ALKBH3 gene associated with? 02/12/2023

ALKBH3 gene mutation is associated with colon and rectal cancer.

What factors are related to the stability of ALKBH3 recombinant protein? 01/24/2023

The stability of ALKBH3 recombinant protein is related to freezing temperature, pH value and ionic strength.

What are the biological functions of human ALKBH3 recombinant protein? 12/31/2022

ALKBH3 is a DNA repair enzyme that repairs methyl groups along DNA strands.

Is ALKBH3 mutation associated with recurrent liver cancer? 11/11/2022

No studies have shown that ALKBH3 mutations are associated with recurrent liver cancer.

Is ALKBH3 gene involved in drug metabolism? 10/15/2022

At present, there is no clear study that ALKBH3 gene is related to drug metabolism.

Can ALKBH3 gene be used as a molecular marker for the prognosis of liver cancer? 01/25/2022

ALKBH3 gene can be used as one of the molecular markers of liver cancer prognosis.

Does ALKBH3 have immunomodulatory effects? 01/11/2022

There is no clear evidence that ALKBH3 recombinant protein has immunomodulatory effects.

Are polymorphisms of ALKBH3 gene associated with any diseases? 08/09/2021

ALKBH3 gene polymorphism is associated with various cancers such as lung cancer, esophageal cancer and colon cancer.

Does ALKBH3 mutation affect DNA damage repair function? 08/06/2021

Mutations in ALKBH3 may affect the function of DNA damage repair.

What is the stability of ALKBH3 recombinant protein? 07/04/2021

ALKBH3 recombinant protein should be stored in a -80℃ refrigerator to ensure stability.

What is the role of ALKBH3 recombinant protein in cancer treatment? 03/11/2021

ALKBH3 recombinant protein can help predict the therapeutic effect and prognosis of some cancers.

Does ALKBH3 gene affect human metabolism? 12/25/2020

ALKBH3 has not been found to affect human metabolic capacity.

Does ALKBH3 have an effect on the immune system? 10/31/2020

No studies have shown that ALKBH3 has an important effect on the immune system.

Does the recommended dosage of ALKBH3 recombinant protein? 06/25/2020

There are no clear dosage guidelines at present, and further research is needed to determine.

Is ALKBH3 related to treatment response of liver cancer? 11/30/2019

ALKBH3 mutation may affect the treatment response of liver cancer.

Can ALKBH3 gene variation be used as an early warning indicator of cancer? 11/10/2019

There is no strong evidence that the ALKBH3 gene variant can be used as an early warning indicator of cancer.

Can ALKBH3 recombinant protein be used as a target for cancer treatment? 10/06/2019

The recombinant ALKBH3 protein may be a potential target for the treatment of some cancers, but further research is needed to confirm it.

Customer Reviews (3)

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Reviews
04/30/2021

    Structure analysis by nuclear magnetic resonance (NMR), X-ray crystallography or electron microscopy showed that ALKBH3 was stable.

    04/28/2021

      Prone to induce immune responses.

      05/11/2019

        Stable under special conditions.

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