ALKBH3
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Official Full Name
alkB, alkylation repair homolog 3 (E. coli)
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Overview
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA;lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the;removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 (PubMed 12486230)). -
Synonyms
ALKBH3; alkB, alkylation repair homolog 3 (E. coli); alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; DEPC 1; prostate cancer antigen 1; prostate cancer antigen-1; alkylated DNA repair protein alkB homolog 3; ABH3; PCA1; DEPC1; DEPC-1; FLJ43614; MGC118790; MGC118792; MGC118793;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ALKBH3 Related Articles
ALKBH3 involved in several pathways and played different roles in them. We selected most pathways ALKBH3 participated on our site, such as ALKBH3 mediated reversal of alkylation damage, DNA Damage Reversal, DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ALKBH3 mediated reversal of alkylation damage | ALKBH3;ASCC3;ASCC1;ASCC2 |
DNA Damage Reversal | ASCC2;ASCC1;ALKBH3;MGMT;ALKBH2;ASCC3 |
DNA Repair | INO80B;PIAS3;RAD1;KIAA0101;CLSPN;RBBP8;UIMC1;TOPBP1;UBE2L6 |
Reversal of alkylation damage by DNA dioxygenases | ASCC3;ASCC1;ASCC2;ALKBH2;ALKBH3 |
ALKBH3 has several biochemical functions, for example, DNA-N1-methyladenine dioxygenase activity, L-ascorbic acid binding, cytosine C-5 DNA demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH3 itself. We selected most functions ALKBH3 had, and list some proteins which have the same functions with ALKBH3. You can find most of the proteins on our site.
Function | Related Protein |
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DNA-N1-methyladenine dioxygenase activity | KDM5D;ALKBH3;ALKBH2;JMJD1C;KDM5BB;PHF2;FTO |
L-ascorbic acid binding | DBH;P4HA1;PLOD3;LEPREL1;PHYH;LEPREL2;EGLN1B;ALKBH3;P4HTM |
cytosine C-5 DNA demethylase activity | ALKBH2;ALKBH3 |
ferrous iron binding | TH;ISCUB;PLOD1;TRR1;TF;ISCU;ALKBH3;ALKBH2;ISCA2 |
protein binding | ACTR6;C6;RAB3B;GOSR2;USP49;HDC;RNF10;TEF;NUP35 |
ALKBH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH3.
GLRX3; GOLGA2; IKZF1; LNX1; AK8; SRPK2; SRPK1
- Q&As
- Reviews
Q&As (17)
Ask a questionALKBH3 gene mutation is associated with colon and rectal cancer.
The stability of ALKBH3 recombinant protein is related to freezing temperature, pH value and ionic strength.
ALKBH3 is a DNA repair enzyme that repairs methyl groups along DNA strands.
No studies have shown that ALKBH3 mutations are associated with recurrent liver cancer.
At present, there is no clear study that ALKBH3 gene is related to drug metabolism.
ALKBH3 gene can be used as one of the molecular markers of liver cancer prognosis.
There is no clear evidence that ALKBH3 recombinant protein has immunomodulatory effects.
ALKBH3 gene polymorphism is associated with various cancers such as lung cancer, esophageal cancer and colon cancer.
Mutations in ALKBH3 may affect the function of DNA damage repair.
ALKBH3 recombinant protein should be stored in a -80℃ refrigerator to ensure stability.
ALKBH3 recombinant protein can help predict the therapeutic effect and prognosis of some cancers.
ALKBH3 has not been found to affect human metabolic capacity.
No studies have shown that ALKBH3 has an important effect on the immune system.
There are no clear dosage guidelines at present, and further research is needed to determine.
ALKBH3 mutation may affect the treatment response of liver cancer.
There is no strong evidence that the ALKBH3 gene variant can be used as an early warning indicator of cancer.
The recombinant ALKBH3 protein may be a potential target for the treatment of some cancers, but further research is needed to confirm it.
Customer Reviews (3)
Write a reviewStructure analysis by nuclear magnetic resonance (NMR), X-ray crystallography or electron microscopy showed that ALKBH3 was stable.
Prone to induce immune responses.
Stable under special conditions.
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