|Official Full Name||alkaline phosphatase, liver/bone/kidney|
|Background||There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and;liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue;non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is;not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme.;The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the;enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal;development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by;hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the;specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript;variants have been described.|
|Synonyms||ALPL; alkaline phosphatase, liver/bone/kidney; HOPS; alkaline phosphatase, tissue-nonspecific isozyme; TNSALP; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase live|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
alpl involved in several pathways and played different roles in them. We selected most pathways alpl participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with alpl were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Folate biosynthesis||ALPP; DHFRL1; ALPI; MOCS1; PTS; GCH2; DHFR; ALPI.2; GGH; QDPRB2|
|Metabolic pathways||MINPP1; BPNT1; HSD17B12; SPHK1; CYP2C8; PHOSPHO1; LIPF; PLCD3A; AMY2A5; DNMT3|
alpl has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by alpl itself. We selected most functions alpl had, and list some proteins which have the same functions with alpl. You can find most of the proteins on our site.
|alkaline phosphatase activity||ALP3; ALPL; ALPI; ALPPL2; ALPP; ALPI.1|
|metal ion binding||RTCB; SP8A; PRDM8; ZFY2; ZFP865; XPNPEP2; B3GNT1; ANTXR2A; NME3; CYP3C1|
|protein binding||CATSPERB; KCNIP3; SLC4A4; TESK1; PLSCR4; ZNF167; ABI2; GPR125; PRAC; FBXL5|
|pyrophosphatase activity||CANT1B; CANT1A; DOM3Z; PRUNE2; GMPS; NUDT19; ALPL; PHOSPHO1|
alpl has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with alpl here. Most of them are supplied by our site. Hope this information will be useful for your research of alpl.
MAP3K14; TRAF2; TRAF3; EIF4A2; lrp; NFKBIA; RELA