ALPL

  • Official Full Name

    alkaline phosphatase, liver/bone/kidney

  • Overview

    There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and;liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue;non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is;not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme.;The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the;enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal;development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by;hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the;specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript;variants have been described.
  • Synonyms

    ALPL; alkaline phosphatase, liver/bone/kidney; HOPS; alkaline phosphatase, tissue-nonspecific isozyme; TNSALP; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase live;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Therapeutic Proteins
  • Protein Pre-coupled Magnetic Beads
  • Calf
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • Calf Intestine
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Liver
  • Human placenta
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Myc
  • DDK
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|SUMO
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALPL-894H Active Recombinant Human ALPL, His tagged HEK293 His Met 1-Ser 502
Human ALPL-5324H Active Native Human Alkaline Phosphatase Human Liver N/A
Human ALPL-25H Active Native Human ALPL Protein Human placenta N/A
Human ALPL-9597H Recombinant Human ALPL, GST-tagged E.coli GST 23-330a.a.
Human ALPL-386H Recombinant Human ALPL Protein, His-tagged HEK293 His
Human ALPL-387H Recombinant Human ALPL Protein, His-tagged E.coli His
Human ALPL-494H Recombinant Human ALPL Protein, GST-tagged Wheat Germ GST
Human ALPL-3092HCL Recombinant Human ALPL cell lysate Human Cell N/A
Human ALPL-8004H Native Human Liver Alkaline Phosphatase Human Liver N/A
Human ALPL-001H Recombinant Human ALPL Protein, His-tagged Mammalian cells His
Human ALPL-P04H Recombinant Human ALPL therapeutic protein N/A
Human ALPL-1994H Recombinant Human ALPL Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ALPL-327H Active Recombinant Human ALPL Protein, His-tagged Mammalian cells His
Human ALPL-192HFL Recombinant Full Length Human ALPL Protein, C-Flag-tagged Mammalian cells Flag
Human ALPL-028H Recombinant Human ALPL Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human ALPL-2458H Recombinant Human ALPL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ALPL-1486HF Recombinant Full Length Human ALPL Protein, GST-tagged In Vitro Cell Free System GST 524 amino acids
Human ALPL-1347HFL Recombinant Full Length Human ALPL Protein, N-His-tagged E.coli His
Human ALPL-01H Active Recombinant Human ALPL Protein (18-501aa), C-His-tagged HEK293 C-His 18-501aa
Human ALPL-0602H Recombinant Human ALPL Protein (Leu18-Ser502), C-His-tagged Mammalian cells C-His Leu18-Ser502
Human ALPL-2458H-B Recombinant Human ALPL Protein Pre-coupled Magnetic Beads HEK293
Human ALPL-0601H Recombinant Human ALPL Protein (Leu18-Ser501), N-His-tagged E.coli N-His Leu18-Ser501
Mouse Alpl-444M Active Recombinant Mouse Alkaline Phosphatase, Liver/Bone/Kidney, His-tagged Mammalian cells His
Mouse Alpl-977M Recombinant Mouse Alpl Protein, His-tagged HEK293 His
Mouse ALPL-1575M Recombinant Mouse ALPL Protein Mammalian Cell His
Mouse Alpl-976M Recombinant Mouse Alpl Protein, Fc-tagged HEK293 Fc
Mouse Alpl-1494M Recombinant Mouse Alpl protein, His-tagged E.coli His Phe18~Arg335 (Accession # P09242)
Mouse Alpl-487M-B Recombinant Mouse Alpl Protein Pre-coupled Magnetic Beads HEK293
Mouse Alpl-487M Recombinant Mouse Alpl Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ALPL-1299M Recombinant Mouse ALPL Protein (20-503 aa), His-tagged E.coli His 20-503 aa
Mouse Alpl-564M Recombinant Mouse Alpl Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Alpl-5784M Recombinant Mouse Alpl Protein, His-tagged Mammalian cells His
Rat ALPL-641R Recombinant Rat ALPL Protein Mammalian Cell His
Rat ALPL-2155R Recombinant Rat ALPL Protein (18-501 aa), His-SUMO-tagged E.coli His/SUMO 18-501 aa
Rat ALPL-297R Recombinant Rat ALPL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ALPL-297R-B Recombinant Rat ALPL Protein Pre-coupled Magnetic Beads HEK293
Calf ALPL-66C Active Native Calf Alkaline Phosphatase Calf Intestine N/A
Cattle ALPL-123C Recombinant Cattle ALPL Protein, His-tagged E.coli N-His Leu18-Arg335
Rhesus Macaque ALPL-310R Recombinant Rhesus monkey ALPL Protein, His-tagged Mammalian Cell His
Rhesus Macaque ALPL-138R Recombinant Rhesus Macaque ALPL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ALPL-138R-B Recombinant Rhesus Macaque ALPL Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ALPL-11240Z Recombinant Zebrafish ALPL Mammalian Cell His
Chicken ALPL-6912C Recombinant Chicken ALPL Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ALPL involved in several pathways and played different roles in them. We selected most pathways ALPL participated on our site, such as Folate biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Folate biosynthesisALP3;GCH1;ALPP;SPRA;MOCS1;QDPRA;QDPR;FPGS;ALPPL2
Metabolic pathwaysPOLR3B;CTPS2;PNLIPRP2;CYP27B1;TPI1;CYP2A12;MAT2AA;TPH2;POLR2F

ALPL has several biochemical functions, for example, alkaline phosphatase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALPL itself. We selected most functions ALPL had, and list some proteins which have the same functions with ALPL. You can find most of the proteins on our site.

Function Related Protein
alkaline phosphatase activityALPI.1;ALPL;ALPPL2;ALPI;ALPP;ALP3
metal ion bindingMT4;EXTL2;GDE1;UNC13A;ZNF497;NRXN2;RHO;NPTXR;SMYD4
protein bindingFAM113A;AZI2;HOXB6;ZFP488;LGR6;BUB1B;KDM5B;YIF1A;KCTD9
pyrophosphatase activityCANT1A;DOM3Z;PHOSPHO1;GMPS;ALPL;CANT1B;PRUNE2;NUDT19

ALPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALPL here. Most of them are supplied by our site. Hope this information will be useful for your research of ALPL.

MAP3K14; TRAF2; TRAF3; EIF4A2; lrp; NFKBIA; RELA

Research Area

Related articles

Xie, M; Xing, GF; et al. Functional role of EMMPRIN in the formation and mineralisation of dental matrix in mouse molars. JOURNAL OF MOLECULAR HISTOLOGY 46:21-32(2015).
Maeland, JA; Radtke, A; et al. Comparison of Z and R3 antigen expression and of genes encoding other antigenic markers in invasive human and bovine Streptococcus agalactiae strains from Norway. VETERINARY MICROBIOLOGY 167:729-733(2013).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
What is the tissue-specific expression pattern of ALPL in different organs and cell types? 12/11/2022

ALPL exhibits tissue-specific expression, with high levels in mineralizing tissues such as bones and teeth, but lower levels in other organs.

How does ALPL activity and expression change during development and aging? 09/09/2022

ALPL activity and expression undergo dynamic changes during development and aging, reflecting the physiological demands for mineralization.

Can ALPL activity be modulated by specific factors or inhibitors, and how does this affect mineralization? 06/23/2021

ALPL activity can be modulated by factors such as pyrophosphate, calcium, and inhibitors like levamisole, which impact mineralization outcomes.

How does ALPL contribute to mineralization processes, such as bone formation and tooth development? 10/26/2019

ALPL plays a critical role in mineralization processes by generating inorganic phosphate, an essential component of hydroxyapatite crystals in bones and teeth.

Can ALPL serve as a diagnostic marker or therapeutic target for mineralization-related diseases? 02/27/2019

ALPL can serve as a diagnostic marker for hypophosphatasia and related mineralization disorders, and therapeutic strategies targeting ALPL are being explored.

How does ALPL deficiency or dysregulation contribute to the pathogenesis of skeletal and dental disorders, such as hypophosphatasia? 08/21/2018

ALPL deficiency or dysregulation is associated with hypophosphatasia, a genetic disorder characterized by impaired mineralization and skeletal abnormalities.

What are the effects of genetic variations or mutations in the ALPL gene on enzyme activity and mineralization phenotypes? 12/19/2017

Genetic variations or mutations in the ALPL gene can lead to altered enzyme activity, affecting mineralization and contributing to disease phenotypes.

How can ALPL activity and function be manipulated to enhance bone regeneration and dental tissue engineering? 08/22/2017

Manipulating ALPL activity and function holds promise for promoting bone regeneration and dental tissue engineering, enhancing mineralization processes and tissue formation.

What are the downstream signaling pathways and molecular interactions regulated by ALPL in mineralization processes? 05/18/2017

ALPL regulates molecular interactions and signaling pathways, including Wnt/尾-catenin, BMP, and FGF signaling, to orchestrate mineralization processes.

What are the regulatory mechanisms controlling ALPL gene expression and enzymatic activity? 01/09/2017

ALPL gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in skeletal development and mineralization.

Customer Reviews (3)

Write a review
Reviews
04/22/2022

    Efficient target protein purification.

    04/05/2018

      Reliable antibody for Western blotting.

      12/20/2017

        Robust enzyme activity measurement.

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