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Official Full Name alkaline phosphatase, liver/bone/kidney
Background There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and;liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue;non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is;not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme.;The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the;enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal;development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by;hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the;specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript;variants have been described.
Synonyms ALPL; alkaline phosphatase, liver/bone/kidney; HOPS; alkaline phosphatase, tissue-nonspecific isozyme; TNSALP; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase live
    • Species :
    • Calf
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • Calf Intestine
    • E.coli
    • HEK293
    • Human Cell
    • Human Liver
    • Human placenta
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • SUMO
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALPL-25H Native Human ALPL Protein Human placenta N/A
    Human ALPL-327H Recombinant Human ALPL Protein, His-tagged NS0 His
    Human ALPL-001H Recombinant Human ALPL Protein, His-tagged NS0 His
    Mouse ALPL-1299M Recombinant Mouse ALPL Protein (20-503 aa), His-tagged E.coli His
    Rat ALPL-2155R Recombinant Rat ALPL Protein (18-501 aa), His-SUMO-tagged E.coli His/SUMO
    Mouse Alpl-5784M Recombinant Mouse Alpl Protein, His-tagged NS0 His
    Human ALPL-1994H Recombinant Human ALPL Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ALPL-3092HCL Recombinant Human ALPL cell lysate Human Cell N/A
    Human ALPL-386H Recombinant Human ALPL Protein, His-tagged HEK293 His
    Human ALPL-387H Recombinant Human ALPL Protein, His-tagged E.coli His
    Human ALPL-494H Recombinant Human ALPL Protein, GST-tagged Wheat Germ GST
    Human ALPL-5324H Native Human Alkaline Phosphatase Human Liver N/A
    Human ALPL-8004H Native Human Liver Alkaline Phosphatase Human Liver N/A
    Human ALPL-894H Recombinant Human ALPL, His tagged Human Cell His
    Human ALPL-9597H Recombinant Human ALPL, GST-tagged E.coli GST
    Human ALPL-P04H Recombinant Human ALPL therapeutic protein N/A
    Mouse Alpl-1494M Recombinant Mouse Alpl protein, His-tagged E.coli His
    Mouse ALPL-1575M Recombinant Mouse ALPL Protein Mammalian Cell His
    Mouse Alpl-444M Recombinant Mouse Alkaline Phosphatase, Liver/Bone/Kidney, His-tagged NS0 His
    Mouse Alpl-976M Recombinant Mouse Alpl Protein, Fc-tagged HEK293 Fc
    Mouse Alpl-977M Recombinant Mouse Alpl Protein, His-tagged HEK293 His
    Rat ALPL-641R Recombinant Rat ALPL Protein Mammalian Cell His
    Rhesus Macaque ALPL-310R Recombinant Rhesus monkey ALPL Protein, His-tagged Mammalian Cell His
    Chicken ALPL-6912C Recombinant Chicken ALPL Mammalian Cell His
    Zebrafish ALPL-11240Z Recombinant Zebrafish ALPL Mammalian Cell His
    Calf ALPL-66C Native Calf Alkaline Phosphatase Calf Intestine N/A

    alpl involved in several pathways and played different roles in them. We selected most pathways alpl participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with alpl were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Folate biosynthesis ALPP; DHFRL1; ALPI; MOCS1; PTS; GCH2; DHFR; ALPI.2; GGH; QDPRB2
    Metabolic pathways MINPP1; BPNT1; HSD17B12; SPHK1; CYP2C8; PHOSPHO1; LIPF; PLCD3A; AMY2A5; DNMT3

    alpl has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by alpl itself. We selected most functions alpl had, and list some proteins which have the same functions with alpl. You can find most of the proteins on our site.

    Function Related Protein
    alkaline phosphatase activity ALP3; ALPL; ALPI; ALPPL2; ALPP; ALPI.1
    metal ion binding RTCB; SP8A; PRDM8; ZFY2; ZFP865; XPNPEP2; B3GNT1; ANTXR2A; NME3; CYP3C1
    protein binding CATSPERB; KCNIP3; SLC4A4; TESK1; PLSCR4; ZNF167; ABI2; GPR125; PRAC; FBXL5
    pyrophosphatase activity CANT1B; CANT1A; DOM3Z; PRUNE2; GMPS; NUDT19; ALPL; PHOSPHO1

    alpl has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with alpl here. Most of them are supplied by our site. Hope this information will be useful for your research of alpl.

    MAP3K14; TRAF2; TRAF3; EIF4A2; lrp; NFKBIA; RELA

    Xie, M; Xing, GF; et al. Functional role of EMMPRIN in the formation and mineralisation of dental matrix in mouse molars. JOURNAL OF MOLECULAR HISTOLOGY 46:21-32(2015).
    Maeland, JA; Radtke, A; et al. Comparison of Z and R3 antigen expression and of genes encoding other antigenic markers in invasive human and bovine Streptococcus agalactiae strains from Norway. VETERINARY MICROBIOLOGY 167:729-733(2013).

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