Recombinant Full Length Human ALPL Protein, N-His-tagged
| Cat.No. : | ALPL-1347HFL |
| Product Overview : | Recombinant Full Length Human ALPL Protein, fused to His-tag at N-terminus, was expressed in E. coli. |
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| Species : | Human |
| Source : | E.coli |
| Tag : | His |
| Description : | This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. |
| Form : | 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. |
| Molecular Mass : | 50.9 kDa |
| AA Sequence : | A DNA sequence encoding human full-length ALPL. |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : | Store at -80 centigrade. |
| Concentration : | >50 ug/mL as determined by microplate BCA method. |
| Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : | Druggable Genome |
| Protein Pathways : | Folate biosynthesis, Metabolic pathways |
| Full Length : | Full L. |
| Gene Name | ALPL alkaline phosphatase, biomineralization associated [ Homo sapiens (human) ] |
| Official Symbol | ALPL |
| Synonyms | HOPS; HPPA; HPPC; HPPI; HPPO; TNAP; TNALP; APTNAP; TNSALP; AP-TNAP; TNS-ALP |
| Gene ID | 249 |
| mRNA Refseq | NM_000478.6 |
| Protein Refseq | NP_000469.3 |
| MIM | 171760 |
| UniProt ID | P05186 |
Not For Human Consumption!
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