ANKRD2
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Official Full Name
ankyrin repeat domain 2 (stretch responsive muscle)
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Overview
ANKRD2 belongs to the conserved muscle ankyrin repeat protein (MARP) family. Expression of MARPs is induced in response;to physiologic stress, injury, and hypertrophy (Miller et al., 2003 (PubMed 14583192)). -
Synonyms
ANKRD2; ankyrin repeat domain 2 (stretch responsive muscle); ankyrin repeat domain-containing protein 2; ARPP; hArpp; ankyrin-repeat protein; skeletal muscle ankyrin repeat protein; MGC104314;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Wheat Germ
- GST
- His
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ANKRD2-580H | Recombinant Human ANKRD2 protein, GST-tagged | Wheat Germ | GST | ||
Human | ANKRD2-9667H | Recombinant Human ANKRD2, GST-tagged | E.coli | GST | 1-221+251-333a.a. | |
Human | ANKRD2-8855HCL | Recombinant Human ANKRD2 293 Cell Lysate | HEK293 | N/A | ||
Human | ANKRD2-2072H | Recombinant Human ANKRD2 Protein, His-tagged | E.coli | His | ||
Human | ANKRD2-1199HF | Recombinant Full Length Human ANKRD2 Protein, GST-tagged | In Vitro Cell Free System | GST | 333 amino acids | |
Human | ANKRD2-5117H | Recombinant Human ANKRD2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | ANKRD2-5192H | Recombinant Human ANKRD2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Mouse | Ankrd2-1632M | Recombinant Mouse Ankrd2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
- Involved Pathway
- Protein Function
- Interacting Protein
ANKRD2 involved in several pathways and played different roles in them. We selected most pathways ANKRD2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANKRD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ANKRD2 has several biochemical functions, for example, RNA polymerase II sequence-specific DNA binding transcription factor binding, chromatin binding, protein kinase B binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANKRD2 itself. We selected most functions ANKRD2 had, and list some proteins which have the same functions with ANKRD2. You can find most of the proteins on our site.
Function | Related Protein |
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RNA polymerase II sequence-specific DNA binding transcription factor binding | |
chromatin binding | TTC5;CBX4;CNBPA;MEOX1;NCOA5;NEUROG1;MCMBP;POLR3D;POLR2B |
protein kinase B binding | CDC37;RARA;APPL1;BCL10;PDE3B;TRAF6;BAD;ANKRD2;CCDC88A |
structural constituent of muscle | DMD;MYBPH;OBSCN;MYL3;TPM1;ACTN2;SMTN;CAPN3;TPM2 |
titin binding | MYBPC3;CALM1;ANKRD2;ANKRD1B;ACTN2;MYBPC1;CALM;CAMK2D;TCAP |
ANKRD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANKRD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANKRD2.
- Q&As
- Reviews
Q&As (15)
Ask a questionDysfunction of ANKRD2 has been associated with various heart diseases. For example, reduced expression or loss of function mutations in ANKRD2 have been found in patients with dilated cardiomyopathy, a condition characterized by a weakened and enlarged heart. ANKRD2 dysfunction can lead to impaired contractility, abnormal calcium signaling, and disruptions in the structural integrity of the sarcomere, all of which contribute to the development of heart disease. Understanding the specific mechanisms of ANKRD2 dysfunction can provide insights into the underlying causes of these diseases and may lead to the development of targeted therapies.
ANKRD2 shows promise as a potential therapeutic target for heart diseases. Its involvement in maintaining cardiac muscle integrity and function suggests that modulating its activity could have beneficial effects on heart health. However, further research is needed to fully understand the complex mechanisms of ANKRD2 and develop targeted therapies.
Yes, there is evidence linking ANKRD2 to arrhythmias. ANKRD2 dysfunction has been associated with an increased risk of developing atrial fibrillation, a common cardiac arrhythmia characterized by irregular and rapid atrial electrical activity. Studies have identified genetic variants and mutations in ANKRD2 that are associated with an increased susceptibility to atrial fibrillation. These variants may disrupt the normal function of ANKRD2 and contribute to abnormal electrical conduction in the heart, leading to arrhythmias.
While ANKRD2 protein is primarily expressed in the heart, it is also found in skeletal muscles, specifically in the fast-twitch muscle fibers.
Mutations or dysregulation of ANKRD2 have been associated with several cardiovascular diseases, including dilated cardiomyopathy and hypertrophic cardiomyopathy. ANKRD2 is believed to play a role in maintaining the structural integrity of the cardiac muscle.
Several genetic variants and mutations in the ANKRD2 gene have been identified. Some of these variants are associated with an increased risk of developing cardiovascular diseases, such as dilated cardiomyopathy and atrial fibrillation. For example, a single nucleotide polymorphism (SNP) in the ANKRD2 gene, known as rs10824026, has been shown to be associated with an increased risk of dilated cardiomyopathy.
Yes, research on ANKRD2 protein is ongoing, particularly in the context of understanding its role in heart diseases. Scientists are exploring the molecular mechanisms through which ANKRD2 functions and how its dysregulation contributes to cardiac muscle disorders.
While ANKRD2 is primarily linked to cardiovascular diseases, recent studies have also suggested its involvement in other conditions. For example, there is evidence that ANKRD2 may play a role in cancer. It has been found to be upregulated in certain types of cancers, including breast, lung, and ovarian cancer. ANKRD2 has been suggested to regulate various processes in cancer cells, such as growth, migration, and invasion. However, more research is needed to fully understand the involvement of ANKRD2 in these diseases.
Yes, ANKRD2 is expressed in other organs and tissues besides the heart. While it is most abundant in cardiac muscle cells, ANKRD2 has been detected in skeletal muscle, smooth muscle, and certain regions of the brain. In skeletal muscle, ANKRD2 is involved in muscle development and regeneration. It also plays a role in smooth muscle contraction and function. In the brain, ANKRD2 is thought to be involved in the regulation of neuronal development and synaptic plasticity. The specific functions of ANKRD2 in these organs and tissues are still being investigated.
Yes, ANKRD2 has been implicated in the regulation of cardiac hypertrophy. Cardiac hypertrophy refers to the enlargement of the heart muscle in response to various stimuli, such as increased workload or stress. ANKRD2 has been shown to play a role in balancing the growth and proliferation of cardiac muscle cells. It helps to prevent excessive hypertrophy by inhibiting the activity of certain signaling molecules that promote cell growth. Dysfunction of ANKRD2 can disrupt this balance, leading to abnormal cardiac hypertrophy, which is associated with heart disease.
ANKRD2 interacts with various proteins involved in the regulation of muscle function, such as titin, myosin, and troponin I. These interactions contribute to the structural and functional roles of ANKRD2 in muscle cells.
Yes, ANKRD2 is known to interact with several proteins and be involved in various signaling pathways. One of the well-studied interactions of ANKRD2 is with the titin protein in cardiac muscle cells. ANKRD2 binds to a specific region of titin, called the N2B element, and helps regulate the stiffness and elasticity of the cardiac muscle. ANKRD2 also interacts with other components of the sarcomere, such as myosin binding protein C and myosin heavy chain, suggesting its involvement in the contractile function of the heart.
Currently, there are no targeted therapies specifically developed for ANKRD2-related heart diseases. However, the identification of ANKRD2 as a key player in cardiac function and its association with heart diseases has provided valuable insights for potential therapeutic interventions. Targeting the pathways and mechanisms affected by ANKRD2 dysfunction may offer future therapeutic strategies.
ANKRD2 has several functions in cardiac muscle cells. It helps maintain the structural integrity of the sarcomere, the basic contractile unit of the muscle. It interacts with titin, a large protein that plays a crucial role in muscle elasticity and force transmission. ANKRD2 also participates in the regulation of gene expression, controlling the expression of specific genes involved in muscle growth and development. It is involved in the modulation of calcium signaling, which is essential for muscle contraction. Additionally, ANKRD2 has been found to play a role in the control of cell size and proliferation in cardiac muscle cells.
The expression of ANKRD2 is regulated by various factors. It is known to be regulated at the transcriptional level, with specific transcription factors binding to the promoter region of the ANKRD2 gene and controlling its expression. In cardiac muscle cells, ANKRD2 expression is also regulated by mechanical stretch and pressure, as well as by hormone signaling pathways. The precise mechanisms of ANKRD2 regulation are still being investigated.
Customer Reviews (4)
Write a reviewResearchers can confidently rely on its capabilities to generate precise and significant results, enhancing the understanding of protein function and dynamics.
Its unique characteristics contribute to obtaining clear and detailed structural information, allowing researchers to gain insights into protein interactions and conformational changes.
Its exceptional purity and stability make it an ideal choice for a wide range of applications, ensuring reliable and reproducible results.
It has demonstrated exceptional effectiveness in WB experiments, showcasing its reliability and precision in detecting and quantifying specific targets.
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