Recombinant Mouse ANXA3 Protein Pre-coupled Magnetic Beads

• Cat.No.: ANXA3-583M-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Mouse
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Anxa3 annexin A3 [ Mus musculus ]
• Official Symbol: ANXA3
• Gene ID: 11745
• mRNA Refseq: NM_013470.2
• Protein Refseq: NP_038498.2
• UniProt ID: O35639

Reviews

10/21/2022

The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.

09/30/2022

the ANXA3 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup.

01/02/2022

Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.

03/28/2021

the ANXA3 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.

11/19/2016

Their expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.

Q&As

Is ANXA3 involved in any diseases or disorders?

ANXA3 has been implicated in several diseases and disorders. For instance, it has been identified as a potential biomarker for lung cancer and colorectal cancer. Additionally, ANXA3 may play a role in inflammation, atherosclerosis, and neuronal development.

Does ANXA3 have any role in inflammation?

Yes, ANXA3 has been implicated in the regulation of inflammation. It has been shown to interact with other proteins involved in the inflammatory response and can modulate the production of pro-inflammatory molecules. ANXA3 may also contribute to the resolution of inflammation by promoting anti-inflammatory processes.

Are there any known genetic variations or mutations in the ANXA3 gene?

Yes, genetic variations and mutations in the ANXA3 gene have been reported. Some of these variations have been associated with certain diseases or traits, such as a higher risk of atherosclerosis or altered red blood cell morphology. However, the functional implications of these variations and their precise connection to disease development are still being investigated.

Are there any known interactions of ANXA3 with other proteins?

Yes, ANXA3 can interact with various proteins to regulate specific cellular processes. For example, it can bind to actin and contribute to cell migration and membrane repair. It can also interact with other annexins or phospholipids to mediate membrane organization and vesicular trafficking.

Are there any known regulatory mechanisms that control ANXA3 expression?

Yes, ANXA3 expression can be regulated by various factors. For example, certain transcription factors, such as SP1 and NF-κB, can bind to the promoter region of ANXA3 and regulate its transcription. Additionally, epigenetic modifications, such as DNA methylation and histone acetylation, can also influence ANXA3 expression levels.

Is ANXA3 associated with any other diseases or conditions?

Besides cancer, ANXA3 has been implicated in the pathogenesis of other diseases and conditions, including autoimmune disorders, cardiovascular diseases, and neurological disorders. However, further research is needed to fully understand the mechanisms by which ANXA3 contributes to these conditions.

Does ANXA3 have any role in cancer progression?

Yes, ANXA3 has been implicated in cancer progression. It is often overexpressed in various cancer types, including breast, lung, colon, and pancreatic cancer. ANXA3 can promote tumor growth, angiogenesis, and metastasis by modulating cell survival, proliferation, and invasion pathways. It has also been associated with chemoresistance in certain cancers.

Where is the ANXA3 protein located within the cell?

ANXA3 is primarily localized in the cytoplasm of cells, but it can also be found associated with the plasma membrane or in the nucleus.

Does ANXA3 have any role in cell proliferation or apoptosis?

While ANXA3 is primarily known for its involvement in membrane organization and cellular processes, it has also been implicated in regulating cell proliferation and apoptosis. Studies have suggested that ANXA3 can modulate cell growth and survival by influencing various signaling pathways and interacting with other proteins involved in these processes.

Can ANXA3 influence cell migration and invasion?

Yes, ANXA3 has been found to be involved in cell migration and invasion, particularly in cancer cells. It can interact with proteins associated with cytoskeletal rearrangement and cell adhesion, facilitating the movement and invasion of cells in various biological processes, including cancer metastasis.

Is ANXA3 involved in any signaling pathways?

ANXA3 has been reported to interact with certain signaling pathways. It can modulate the activity of the Wnt/β-catenin pathway, which is implicated in cell proliferation and tissue homeostasis. ANXA3 may also be involved in the regulation of calcium signaling pathways.

Can ANXA3 be used as a diagnostic marker for cancer?

ANXA3 has shown promise as a potential diagnostic marker for certain types of cancer, including lung cancer and colorectal cancer. Elevated levels of ANXA3 have been observed in the blood or tissue samples of patients with these cancers. However, further research is needed to validate its diagnostic utility.

Is ANXA3 involved in cellular signaling pathways?

Yes, ANXA3 has been found to interact with several signaling molecules and participate in various signaling pathways. It can activate the Akt/mTOR pathway, MAPK/ERK pathway, and PI3K/Akt pathway, among others. These interactions indicate that ANXA3 plays a role in cell signaling and can influence cell survival, proliferation, and differentiation.

Is ANXA3 targeted by any drugs or therapies?

Currently, there are no specific drugs or therapies that directly target ANXA3. However, given its potential involvement in cancer and other diseases, it is an area of ongoing research and may become a target for future therapeutic interventions.

Does ANXA3 have diagnostic or prognostic potential in cancer?

ANXA3 has been proposed as a potential biomarker for cancer diagnosis and prognosis. Elevated levels of ANXA3 have been associated with poor prognosis in several cancer types, suggesting that it could serve as a prognostic indicator. ANXA3 expression levels in blood or tissue samples can also be used to distinguish cancer patients from healthy individuals.

Can ANXA3 serve as a therapeutic target?

The potential therapeutic targeting of ANXA3 is currently under investigation. Understanding its precise role and interactions in different diseases could help in developing targeted therapies. However, more research is needed to determine the feasibility and efficacy of targeting ANXA3 for therapeutic purposes.

What are the tissue distribution patterns of ANXA3 protein?

ANXA3 protein is found in various tissues of the body, including the gastrointestinal tract, lungs, kidneys, and reproductive organs. It is also detected in certain cancers such as lung cancer and colorectal cancer.

Is ANXA3 involved in any other biological processes?

Yes, ANXA3 is involved in various biological processes beyond cancer. It has been implicated in cell apoptosis, calcium ion regulation, membrane repair, exocytosis, and cellular differentiation. Further research is needed to fully elucidate the precise roles and functions of ANXA3 in these processes.