Recombinant Human Annexin A3

Cat.No. : ANXA3-1834H
Product Overview : Recombinant human ANXA3 was expressed inE.coliand purified by using conventional chromatography techniques. MW = 36.3 kDa (323aa).
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Cat. No. : ANXA3-1834H
Description : Annexin A3, also known as ANXA3, belong to the calcium dependent phospholipid binding protein family which play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1, 2 cyclic phosphates to form inositol 1 phosphate. It has been reported for the signaling cascade in rat liver regeneration.
Source : E.coli.
Form : Liquid. In 20mM Tris-HCl buffer (pH7.5) containing 1mM DTT, 10% glycerol.
Purity : > 90% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MASIWVGHRG TVRDYPDFSP SVDAEAIQKA IRGIGTDEKM LISILTERSN AQRQLIVKEY QAAYGKELKD DLKGDLSGHF EHLMVALVTPPAVFDAKQLK KSMKGAGTNE DALIEILTTR TSRQMKDISQ AYYTVYKKSL GDDISSETSG DFRKALLTLA DGRRDESLKV DEHLAKQDAQILYKAGENRW GTDEDKFTEI LCLRSFPQLK LTFDEYRNIS QKDIVDSIKG ELSGHFEDLL LAIVNCVRNT PAFLAERLHR ALKGIGTDEFTLNRIMVSRS EIDLLDIRTE FKKHYGYSLY SAIKSDTSGD YEITLLKICG GDD.
Storage : can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : ANXA3 annexin A3 [ Homo sapiens ]
Synonyms : annexin A3; ANX3; ANXA3; PAP-III; annexin-3; lipocortin III; 35-alpha calcimedin; calcimedin 35-alpha; Annexin III (lipocortin III); placental anticoagulant protein III; inositol 1,2-cyclic phosphate 2-phosphohydrolase; annexin III (lipocortin III, 1,2-cyclic-inositol-phosphate phosphodiesterase, placental anticoagulant protein III, calcimedin 35-alpha);Placental anticoagulant protein III; Lipocortin III; Annexin-3; Annexin III
Gene ID : 306
mRNA Refseq : NM_005139
Protein Refseq : NP_005130
MIM : 106490
UniProt ID : P12429
Chromosome Location : 4q13-q22
Function : calcium ion binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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Is ANXA3 involved in any diseases or disorders? 04/14/2023

ANXA3 has been implicated in several diseases and disorders. For instance, it has been identified as a potential biomarker for lung cancer and colorectal cancer. Additionally, ANXA3 may play a role in inflammation, atherosclerosis, and neuronal development.

Does ANXA3 have any role in inflammation? 04/07/2022

Yes, ANXA3 has been implicated in the regulation of inflammation. It has been shown to interact with other proteins involved in the inflammatory response and can modulate the production of pro-inflammatory molecules. ANXA3 may also contribute to the resolution of inflammation by promoting anti-inflammatory processes.

Are there any known genetic variations or mutations in the ANXA3 gene? 10/12/2020

Yes, genetic variations and mutations in the ANXA3 gene have been reported. Some of these variations have been associated with certain diseases or traits, such as a higher risk of atherosclerosis or altered red blood cell morphology. However, the functional implications of these variations and their precise connection to disease development are still being investigated.

Are there any known interactions of ANXA3 with other proteins? 09/05/2020

Yes, ANXA3 can interact with various proteins to regulate specific cellular processes. For example, it can bind to actin and contribute to cell migration and membrane repair. It can also interact with other annexins or phospholipids to mediate membrane organization and vesicular trafficking.

Are there any known regulatory mechanisms that control ANXA3 expression? 08/24/2020

Yes, ANXA3 expression can be regulated by various factors. For example, certain transcription factors, such as SP1 and NF-κB, can bind to the promoter region of ANXA3 and regulate its transcription. Additionally, epigenetic modifications, such as DNA methylation and histone acetylation, can also influence ANXA3 expression levels.

Is ANXA3 associated with any other diseases or conditions? 01/13/2020

Besides cancer, ANXA3 has been implicated in the pathogenesis of other diseases and conditions, including autoimmune disorders, cardiovascular diseases, and neurological disorders. However, further research is needed to fully understand the mechanisms by which ANXA3 contributes to these conditions.

Does ANXA3 have any role in cancer progression? 08/08/2019

Yes, ANXA3 has been implicated in cancer progression. It is often overexpressed in various cancer types, including breast, lung, colon, and pancreatic cancer. ANXA3 can promote tumor growth, angiogenesis, and metastasis by modulating cell survival, proliferation, and invasion pathways. It has also been associated with chemoresistance in certain cancers.

Where is the ANXA3 protein located within the cell? 04/26/2019

ANXA3 is primarily localized in the cytoplasm of cells, but it can also be found associated with the plasma membrane or in the nucleus.

Does ANXA3 have any role in cell proliferation or apoptosis? 11/17/2018

While ANXA3 is primarily known for its involvement in membrane organization and cellular processes, it has also been implicated in regulating cell proliferation and apoptosis. Studies have suggested that ANXA3 can modulate cell growth and survival by influencing various signaling pathways and interacting with other proteins involved in these processes.

Can ANXA3 influence cell migration and invasion? 09/10/2018

Yes, ANXA3 has been found to be involved in cell migration and invasion, particularly in cancer cells. It can interact with proteins associated with cytoskeletal rearrangement and cell adhesion, facilitating the movement and invasion of cells in various biological processes, including cancer metastasis.

Is ANXA3 involved in any signaling pathways? 08/12/2018

ANXA3 has been reported to interact with certain signaling pathways. It can modulate the activity of the Wnt/β-catenin pathway, which is implicated in cell proliferation and tissue homeostasis. ANXA3 may also be involved in the regulation of calcium signaling pathways.

Can ANXA3 be used as a diagnostic marker for cancer? 08/05/2018

ANXA3 has shown promise as a potential diagnostic marker for certain types of cancer, including lung cancer and colorectal cancer. Elevated levels of ANXA3 have been observed in the blood or tissue samples of patients with these cancers. However, further research is needed to validate its diagnostic utility.

Is ANXA3 involved in cellular signaling pathways? 05/20/2018

Yes, ANXA3 has been found to interact with several signaling molecules and participate in various signaling pathways. It can activate the Akt/mTOR pathway, MAPK/ERK pathway, and PI3K/Akt pathway, among others. These interactions indicate that ANXA3 plays a role in cell signaling and can influence cell survival, proliferation, and differentiation.

Is ANXA3 targeted by any drugs or therapies? 07/12/2017

Currently, there are no specific drugs or therapies that directly target ANXA3. However, given its potential involvement in cancer and other diseases, it is an area of ongoing research and may become a target for future therapeutic interventions.

Does ANXA3 have diagnostic or prognostic potential in cancer? 03/18/2017

ANXA3 has been proposed as a potential biomarker for cancer diagnosis and prognosis. Elevated levels of ANXA3 have been associated with poor prognosis in several cancer types, suggesting that it could serve as a prognostic indicator. ANXA3 expression levels in blood or tissue samples can also be used to distinguish cancer patients from healthy individuals.

Can ANXA3 serve as a therapeutic target? 10/15/2016

The potential therapeutic targeting of ANXA3 is currently under investigation. Understanding its precise role and interactions in different diseases could help in developing targeted therapies. However, more research is needed to determine the feasibility and efficacy of targeting ANXA3 for therapeutic purposes.

What are the tissue distribution patterns of ANXA3 protein? 05/05/2016

ANXA3 protein is found in various tissues of the body, including the gastrointestinal tract, lungs, kidneys, and reproductive organs. It is also detected in certain cancers such as lung cancer and colorectal cancer.

Is ANXA3 involved in any other biological processes? 02/14/2016

Yes, ANXA3 is involved in various biological processes beyond cancer. It has been implicated in cell apoptosis, calcium ion regulation, membrane repair, exocytosis, and cellular differentiation. Further research is needed to fully elucidate the precise roles and functions of ANXA3 in these processes.

Customer Reviews (5)

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Reviews
10/21/2022

    The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance. -

    09/30/2022

      the ANXA3 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup. -

      01/02/2022

        Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways. -

        03/28/2021

          the ANXA3 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications. -

          11/19/2016

            Their expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise. -

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